macroautophagy Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. (Gene Ontology, GO_0016236)
External Link http://amigo.geneontology.org/amigo/term/GO_0016236
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Genes

105 genes participating in the macroautophagy biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
ACBD5 acyl-CoA binding domain containing 5
ARL8B ADP-ribosylation factor-like 8B
ATG10 autophagy related 10
ATG12 autophagy related 12
ATG14 autophagy related 14
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG16L2 autophagy related 16-like 2 (S. cerevisiae)
ATG4B autophagy related 4B, cysteine peptidase
ATG5 autophagy related 5
ATG7 autophagy related 7
ATP13A2 ATPase type 13A2
BECN1 beclin 1, autophagy related
CALCOCO2 calcium binding and coiled-coil domain 2
CALR calreticulin
CHMP1A charged multivesicular body protein 1A
CHMP1B charged multivesicular body protein 1B
CHMP2A charged multivesicular body protein 2A
CHMP2B charged multivesicular body protein 2B
CHMP3 charged multivesicular body protein 3
CHMP4A charged multivesicular body protein 4A
CHMP4C charged multivesicular body protein 4C
CHMP5 charged multivesicular body protein 5
CHMP6 charged multivesicular body protein 6
CHMP7 charged multivesicular body protein 7
CLN3 ceroid-lipofuscinosis, neuronal 3
EI24 etoposide induced 2.4
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
GABARAPL3 GABA(A) receptors associated protein like 3, pseudogene
HDAC10 histone deacetylase 10
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains
IRGM immunity-related GTPase family, M
KIAA0226L KIAA0226-like
KLHL3 kelch-like family member 3
LAMP2 lysosomal-associated membrane protein 2
LIX1 Lix1 homolog (chicken)
LIX1L Lix1 homolog (chicken) like
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma
MTMR14 myotubularin related protein 14
MTMR3 myotubularin related protein 3
MVB12A multivesicular body subunit 12A
NBR1 neighbor of BRCA1 gene 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PGAM5 phosphoglycerate mutase family member 5
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAA phospholipase A2-activating protein
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
SNAP29 synaptosomal-associated protein, 29kDa
SNF8 SNF8, ESCRT-II complex subunit
SNX14 sorting nexin 14
SNX18 sorting nexin 18
SPG11 spastic paraplegia 11 (autosomal recessive)
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STK3 serine/threonine kinase 3
STX17 syntaxin 17
TBC1D5 TBC1 domain family, member 5
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TECPR1 tectonin beta-propeller repeat containing 1
TGFB1 transforming growth factor, beta 1
TMEM74 transmembrane protein 74
TOM1 target of myb1 (chicken)
TSG101 tumor susceptibility 101
UBA5 ubiquitin-like modifier activating enzyme 5
UBQLN1 ubiquilin 1
UBXN6 UBX domain protein 6
ULK1 unc-51 like autophagy activating kinase 1
UVRAG UV radiation resistance associated
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
VCP valosin containing protein
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VTA1 vesicle (multivesicular body) trafficking 1
VTI1A vesicle transport through interaction with t-SNAREs 1A
VTI1B vesicle transport through interaction with t-SNAREs 1B
WIPI2 WD repeat domain, phosphoinositide interacting 2
YOD1 YOD1 deubiquitinase
ZFYVE1 zinc finger, FYVE domain containing 1
ZFYVE26 zinc finger, FYVE domain containing 26