macroautophagy Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane-bounded autophagic bodies which are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded. (Gene Ontology, GO_0016236)
External Link http://amigo.geneontology.org/amigo/term/GO:0016236
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Genes

163 genes participating in the macroautophagy biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ABI2 abl-interactor 2
ACBD5 acyl-CoA binding domain containing 5
AMBRA1 autophagy/beclin-1 regulator 1
ARFIP2 ADP-ribosylation factor interacting protein 2
ARHGAP26 Rho GTPase activating protein 26
ARL8B ADP-ribosylation factor-like 8B
ARMC3 armadillo repeat containing 3
ATG10 autophagy related 10
ATG12 autophagy related 12
ATG13 autophagy related 13
ATG14 autophagy related 14
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
ATG16L2 autophagy related 16-like 2 (S. cerevisiae)
ATG2A autophagy related 2A
ATG2B autophagy related 2B
ATG3 autophagy related 3
ATG4A autophagy related 4A, cysteine peptidase
ATG4B autophagy related 4B, cysteine peptidase
ATG4C autophagy related 4C, cysteine peptidase
ATG4D autophagy related 4D, cysteine peptidase
ATG5 autophagy related 5
ATG7 autophagy related 7
ATG9A autophagy related 9A
ATG9B autophagy related 9B
ATM ATM serine/threonine kinase
ATP13A2 ATPase type 13A2
AUP1 ancient ubiquitous protein 1
BECN1 beclin 1, autophagy related
BECN2 beclin 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALCOCO2 calcium binding and coiled-coil domain 2
CHMP1A charged multivesicular body protein 1A
CHMP1B charged multivesicular body protein 1B
CHMP2A charged multivesicular body protein 2A
CHMP2B charged multivesicular body protein 2B
CHMP4B charged multivesicular body protein 4B
CHMP4C charged multivesicular body protein 4C
CHMP5 charged multivesicular body protein 5
CHMP6 charged multivesicular body protein 6
CHMP7 charged multivesicular body protein 7
CLEC16A C-type lectin domain family 16, member A
CLN3 ceroid-lipofuscinosis, neuronal 3
CTSK cathepsin K
DDRGK1 DDRGK domain containing 1
EI24 etoposide induced 2.4
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans)
FUNDC1 FUN14 domain containing 1
GABARAP GABA(A) receptor-associated protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABARAPL2 GABA(A) receptor-associated protein-like 2
HDAC10 histone deacetylase 10
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains
IRGM immunity-related GTPase family, M
KLHL3 kelch-like family member 3
LAMP2 lysosomal-associated membrane protein 2
LGALS8 lectin, galactoside-binding, soluble, 8
LIX1 Lix1 homolog (chicken)
LIX1L Lix1 homolog (chicken) like
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma
MFSD8 major facilitator superfamily domain containing 8
MTMR14 myotubularin related protein 14
MTMR3 myotubularin related protein 3
MVB12A multivesicular body subunit 12A
NBR1 neighbor of BRCA1 gene 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NIPSNAP2 nipsnap homolog 2
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDCD6IP programmed cell death 6 interacting protein
PEX2 peroxisomal biogenesis factor 2
PEX5 peroxisomal biogenesis factor 5
PGAM5 phosphoglycerate mutase family member 5
PHB2 prohibitin 2
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PINK1 PTEN induced putative kinase 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PJVK pejvakin
PLAA phospholipase A2-activating protein
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRKN parkin RBR E3 ubiquitin protein ligase
RAB2A RAB2A, member RAS oncogene family
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RAB7A RAB7A, member RAS oncogene family
RB1CC1 RB1-inducible coiled-coil 1
RETREG1 reticulophagy regulator 1
RETREG3 reticulophagy regulator family member 3
RIMOC1 RAB7A interacting MON1-CCZ1 complex subunit 1
RNF103-CHMP3 RNF103-CHMP3 readthrough
RNF213 ring finger protein 213
RUBCNL rubicon like autophagy enhancer
SNAP29 synaptosomal-associated protein, 29kDa
SNF8 SNF8, ESCRT-II complex subunit
SNX14 sorting nexin 14
SNX30 sorting nexin family member 30
SNX7 sorting nexin 7
SPART spartin
SPATA33 spermatogenesis associated 33
SPATA5L1 spermatogenesis associated 5-like 1
SPG11 spastic paraplegia 11 (autosomal recessive)
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
STBD1 starch binding domain 1
STING1 stimulator of interferon response cGAMP interactor 1
STX17 syntaxin 17
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase
TBC1D5 TBC1 domain family, member 5
TBK1 TANK-binding kinase 1
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TECPR1 tectonin beta-propeller repeat containing 1
TEX264 testis expressed 264
TMEM74 transmembrane protein 74
TOM1 target of myb1 (chicken)
TSG101 tumor susceptibility 101
UBA5 ubiquitin-like modifier activating enzyme 5
UBQLN1 ubiquilin 1
UBXN6 UBX domain protein 6
UFC1 ubiquitin-fold modifier conjugating enzyme 1
UFL1 UFM1-specific ligase 1
UFM1 ubiquitin-fold modifier 1
ULK1 unc-51 like autophagy activating kinase 1
ULK2 unc-51 like autophagy activating kinase 2
ULK3 unc-51 like kinase 3
USP30 ubiquitin specific peptidase 30
UVRAG UV radiation resistance associated
VAMP7 vesicle-associated membrane protein 7
VAMP8 vesicle-associated membrane protein 8
VCP valosin containing protein
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
VPS33B vacuolar protein sorting 33 homolog B (yeast)
VPS36 vacuolar protein sorting 36 homolog (S. cerevisiae)
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae)
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae)
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae)
VPS37D vacuolar protein sorting 37 homolog D (S. cerevisiae)
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
VPS4A vacuolar protein sorting 4 homolog A (S. cerevisiae)
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VTA1 vesicle (multivesicular body) trafficking 1
VTI1A vesicle transport through interaction with t-SNAREs 1A
VTI1B vesicle transport through interaction with t-SNAREs 1B
WDFY3 WD repeat and FYVE domain containing 3
WDR45 WD repeat domain 45
WDR45B WD repeat domain 45B
WDR81 WD repeat domain 81
WIPI1 WD repeat domain, phosphoinositide interacting 1
WIPI2 WD repeat domain, phosphoinositide interacting 2
YOD1 YOD1 deubiquitinase
ZFYVE1 zinc finger, FYVE domain containing 1
ZFYVE26 zinc finger, FYVE domain containing 26