macromolecule catabolic process Gene Set

Dataset GO Biological Process Annotations 2023
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. (Gene Ontology, GO_0009057)
External Link http://amigo.geneontology.org/amigo/term/GO_0009057
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Genes

86 genes participating in the macromolecule catabolic process biological process from the curated GO Biological Process Annotations 2023 dataset.

Symbol Name
AOAH acyloxyacyl hydrolase (neutrophil)
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
BECN1 beclin 1, autophagy related
CAPN3 calpain 3, (p94)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CHEK2 checkpoint kinase 2
CLN5 ceroid-lipofuscinosis, neuronal 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CTRL chymotrypsin-like
DAB2IP DAB2 interacting protein
DENND3 DENN/MADD domain containing 3
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
DIS3L DIS3 like exosome 3'-5' exoribonuclease
DNASE1 deoxyribonuclease I
DNASE1L1 deoxyribonuclease I-like 1
DNASE1L2 deoxyribonuclease I-like 2
DNASE1L3 deoxyribonuclease I-like 3
ELANE elastase, neutrophil expressed
EXOSC1 exosome component 1
EXOSC10 exosome component 10
EXOSC2 exosome component 2
EXOSC3 exosome component 3
EXOSC4 exosome component 4
EXOSC5 exosome component 5
EXOSC6 exosome component 6
EXOSC7 exosome component 7
EXOSC8 exosome component 8
EXOSC9 exosome component 9
FBH1 F-box DNA helicase 1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HTRA2 HtrA serine peptidase 2
IDE insulin-degrading enzyme
ISG20 interferon stimulated exonuclease gene 20kDa
KIF16B kinesin family member 16B
LGMN legumain
LRSAM1 leucine rich repeat and sterile alpha motif containing 1
MAGEA2 melanoma antigen family A2
MAGEC2 melanoma antigen family C2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTREX Mtr4 exosome RNA helicase
MUS81 MUS81 structure-specific endonuclease subunit
MVB12A multivesicular body subunit 12A
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
PABPC4 poly(A) binding protein, cytoplasmic 4 (inducible form)
PARK2 parkin RBR E3 ubiquitin protein ligase
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PNPT1 polyribonucleotide nucleotidyltransferase 1
PPP1R8 protein phosphatase 1, regulatory subunit 8
PPT1 palmitoyl-protein thioesterase 1
PRSS16 protease, serine, 16 (thymus)
RAB12 RAB12, member RAS oncogene family
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNASE3 ribonuclease, RNase A family, 3
RNASE6 ribonuclease, RNase A family, k6
RNASEH1 ribonuclease H1
RNASEH2A ribonuclease H2, subunit A
RNASEH2B ribonuclease H2, subunit B
RNASEH2C ribonuclease H2, subunit C
RNASET2 ribonuclease T2
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
SETMAR SET domain and mariner transposase fusion gene
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIAH1 siah E3 ubiquitin protein ligase 1
SIDT2 SID1 transmembrane family, member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNX25 sorting nexin 25
SQSTM1 sequestosome 1
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TGFB1 transforming growth factor, beta 1
TPP1 tripeptidyl peptidase I
TREX1 three prime repair exonuclease 1
TREX2 three prime repair exonuclease 2
TRIM24 tripartite motif containing 24
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae)
UTP25 UTP25 small subunit processome component
UVRAG UV radiation resistance associated
XRN2 5'-3' exoribonuclease 2