macromolecule catabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. (Gene Ontology, GO_0009057)
External Link http://amigo.geneontology.org/amigo/term/GO:0009057
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Genes

47 genes participating in the macromolecule catabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACD adrenocortical dysplasia homolog (mouse)
AFG3L2 AFG3-like AAA ATPase 2
AOAH acyloxyacyl hydrolase (neutrophil)
BECN1 beclin 1, autophagy related
CAPN3 calpain 3, (p94)
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CHEK2 checkpoint kinase 2
CLN5 ceroid-lipofuscinosis, neuronal 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)
CTRL chymotrypsin-like
DAB2IP DAB2 interacting protein
DENND3 DENN/MADD domain containing 3
ELANE elastase, neutrophil expressed
HTRA2 HtrA serine peptidase 2
IDE insulin-degrading enzyme
KIF16B kinesin family member 16B
LAMP2 lysosomal-associated membrane protein 2
LGMN legumain
LONP1 lon peptidase 1, mitochondrial
LRSAM1 leucine rich repeat and sterile alpha motif containing 1
MAGEA2 melanoma antigen family A2
MAGEC2 melanoma antigen family C2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MVB12A multivesicular body subunit 12A
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PPT1 palmitoyl-protein thioesterase 1
PRSS16 protease, serine, 16 (thymus)
RAB12 RAB12, member RAS oncogene family
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIAH1 siah E3 ubiquitin protein ligase 1
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNX25 sorting nexin 25
SQSTM1 sequestosome 1
TGFB1 transforming growth factor, beta 1
TRIM24 tripartite motif containing 24
UBE2Z ubiquitin-conjugating enzyme E2Z
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UTP25 UTP25 small subunit processome component
UVRAG UV radiation resistance associated