macular degeneration Gene Set

Dataset DISEASES Experimental Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye; symptoms include vision loss. (Human Disease Ontology, DOID_4448)
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40 genes associated with the disease macular degeneration in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
CFH complement factor H 3.31608
HTRA1 HtrA serine peptidase 1 3.31608
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 2.50425
CFB complement factor B 1.51016
APOC1 apolipoprotein C-I 1.37597
COL8A1 collagen, type VIII, alpha 1 0.923046
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 0.894262
NOTCH4 notch 4 0.790827
IER3 immediate early response 3 0.790827
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 0.790827
LIPC lipase, hepatic 0.774217
TGFBR1 transforming growth factor, beta receptor 1 0.774217
CCDC109B coiled-coil domain containing 109B 0.738873
RAD51B RAD51 paralog B 0.728541
NELFE negative elongation factor complex member E 0.69843
CFI complement factor I 0.670996
ATF6B activating transcription factor 6 beta 0.63207
TNXB tenascin XB 0.63207
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.561725
CETP cholesteryl ester transfer protein, plasma 0.544585
VEGFA vascular endothelial growth factor A 0.5306
FRK fyn-related Src family tyrosine kinase 0.52461
C3 complement component 3 0.52461
B3GALTL beta 1,3-galactosyltransferase-like 0.486425
REST RE1-silencing transcription factor 0.486425
NT5DC1 5'-nucleotidase domain containing 1 0.486425
COL10A1 collagen, type X, alpha 1 0.486425
MCHR2 melanin-concentrating hormone receptor 2 0.311576
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.256228
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 0.256228
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 0.256228
MBL2 mannose-binding lectin (protein C) 2, soluble 0.197766
SCPEP1 serine carboxypeptidase 1 0.197766
TYR tyrosinase 0.126165
C1ORF132 chromosome 1 open reading frame 132 0.100789
NMRK2 nicotinamide riboside kinase 2 0.080593
POSTN periostin, osteoblast specific factor 0.080593
RAB30 RAB30, member RAS oncogene family 0.052255
CLIC5 chloride intracellular channel 5 0.052255
GLI3 GLI family zinc finger 3 0.043246