mafenide-5499 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the mafenide-5499 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ARL4C ADP-ribosylation factor-like 4C
BAIAP2 BAI1-associated protein 2
BTD biotinidase
CALD1 caldesmon 1
CCDC64 coiled-coil domain containing 64
CD52 CD52 molecule
CDC25C cell division cycle 25C
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
COL1A1 collagen, type I, alpha 1
CSHL1 chorionic somatomammotropin hormone-like 1
DACH1 dachshund family transcription factor 1
DAGLA diacylglycerol lipase, alpha
DDN dendrin
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DENND3 DENN/MADD domain containing 3
DIAPH2 diaphanous-related formin 2
DLK2 delta-like 2 homolog (Drosophila)
DTNA dystrobrevin, alpha
DVL3 dishevelled segment polarity protein 3
EDAR ectodysplasin A receptor
FAM13A family with sequence similarity 13, member A
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FLOT1 flotillin 1
GAP43 growth associated protein 43
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GIMAP5 GTPase, IMAP family member 5
GLRX3 glutaredoxin 3
GSTP1 glutathione S-transferase pi 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFNA17 interferon, alpha 17
IGHA1 immunoglobulin heavy constant alpha 1
IGLJ3 immunoglobulin lambda joining 3
ING2 inhibitor of growth family, member 2
IPO5 importin 5
IQCG IQ motif containing G
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KIAA0754 KIAA0754
KLHL22 kelch-like family member 22
KRT1 keratin 1, type II
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LENEP lens epithelial protein
LMAN1 lectin, mannose-binding, 1
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPK14 mitogen-activated protein kinase 14
MAPK7 mitogen-activated protein kinase 7
MARK4 MAP/microtubule affinity-regulating kinase 4
MT4 metallothionein 4
MUC1 mucin 1, cell surface associated
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFX1 nuclear transcription factor, X-box binding 1
NOX5 NADPH oxidase, EF-hand calcium binding domain 5
NRG2 neuregulin 2
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
OVOL1 ovo-like zinc finger 1
PCDHGA10 protocadherin gamma subfamily A, 10
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM5 PDZ and LIM domain 5
PLD3 phospholipase D family, member 3
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRSS50 protease, serine, 50
PSD3 pleckstrin and Sec7 domain containing 3
PSG9 pregnancy specific beta-1-glycoprotein 9
PTGIS prostaglandin I2 (prostacyclin) synthase
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNGTT RNA guanylyltransferase and 5'-phosphatase
RORC RAR-related orphan receptor C
RRBP1 ribosome binding protein 1
RREB1 ras responsive element binding protein 1
RUNDC3A RUN domain containing 3A
SENP5 SUMO1/sentrin specific peptidase 5
SIRAL2 SIR2 antiphage like 2
SIRT3 sirtuin 3
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLN sarcolipin
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOGA1 suppressor of glucose, autophagy associated 1
SOX2 SRY (sex determining region Y)-box 2
SPEG SPEG complex locus
STATH statherin
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TGM2 transglutaminase 2
TPMT thiopurine S-methyltransferase
TPSAB1 tryptase alpha/beta 1
TRAFD1 TRAF-type zinc finger domain containing 1
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WBP2 WW domain binding protein 2
WFDC2 WAP four-disulfide core domain 2
ZMYND8 zinc finger, MYND-type containing 8
ZNF318 zinc finger protein 318

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AP4M1 adaptor-related protein complex 4, mu 1 subunit
ATP13A2 ATPase type 13A2
BAG4 BCL2-associated athanogene 4
BATF basic leucine zipper transcription factor, ATF-like
BBS7 Bardet-Biedl syndrome 7
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L2 BCL2-like 2
BCL9 B-cell CLL/lymphoma 9
BRAF B-Raf proto-oncogene, serine/threonine kinase
CAMTA2 calmodulin binding transcription activator 2
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD83 CD83 molecule
CDK20 cyclin-dependent kinase 20
CENPO centromere protein O
CHEK2 checkpoint kinase 2
CIDEC cell death-inducing DFFA-like effector c
CINP cyclin-dependent kinase 2 interacting protein
CLCN5 chloride channel, voltage-sensitive 5
CNKSR1 connector enhancer of kinase suppressor of Ras 1
CPPED1 calcineurin-like phosphoesterase domain containing 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBR1 debranching RNA lariats 1
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSCAM Down syndrome cell adhesion molecule
EDC3 enhancer of mRNA decapping 3
EFHD2 EF-hand domain family, member D2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELOVL4 ELOVL fatty acid elongase 4
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
FADS3 fatty acid desaturase 3
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FURIN furin (paired basic amino acid cleaving enzyme)
GBP2 guanylate binding protein 2, interferon-inducible
GID4 GID complex subunit 4
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GLI3 GLI family zinc finger 3
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GRAMD4 GRAM domain containing 4
GSTT1 glutathione S-transferase theta 1
IL15RA interleukin 15 receptor, alpha
IL2 interleukin 2
KLK5 kallikrein-related peptidase 5
LRP2 low density lipoprotein receptor-related protein 2
LRRC20 leucine rich repeat containing 20
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LZTFL1 leucine zipper transcription factor-like 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPKBP1 mitogen-activated protein kinase binding protein 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MED24 mediator complex subunit 24
MPST mercaptopyruvate sulfurtransferase
NDRG1 N-myc downstream regulated 1
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NES nestin
NIPAL2 NIPA-like domain containing 2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NR1D2 nuclear receptor subfamily 1, group D, member 2
PROCR protein C receptor, endothelial
PRODH proline dehydrogenase (oxidase) 1
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PYGB phosphorylase, glycogen; brain
PYGL phosphorylase, glycogen, liver
RAB23 RAB23, member RAS oncogene family
RBM42 RNA binding motif protein 42
RFX7 regulatory factor X, 7
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF126P1 ring finger protein 126 pseudogene 1
RPUSD2 RNA pseudouridylate synthase domain containing 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGPP1 sphingosine-1-phosphate phosphatase 1
SKI SKI proto-oncogene
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SNAI2 snail family zinc finger 2
SRPX sushi-repeat containing protein, X-linked
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK16 serine/threonine kinase 16
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TCTN1 tectonic family member 1
TESC tescalcin
TLR5 toll-like receptor 5
TMEM230 transmembrane protein 230
TMEM53 transmembrane protein 53
TRAPPC6A trafficking protein particle complex 6A
TRIM36 tripartite motif containing 36
TRIM66 tripartite motif containing 66
TTBK2 tau tubulin kinase 2
TWF2 twinfilin actin binding protein 2
ZNF254 zinc finger protein 254
ZNF34 zinc finger protein 34
ZNF668 zinc finger protein 668