maintenance of blood-brain barrier Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description Preserving the permeability barrier between the blood and the brain in a stable functional or structural state. The cells in the brain are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier. (Gene Ontology, GO_0035633)
External Link http://amigo.geneontology.org/amigo/term/GO:0035633
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Genes

30 genes participating in the maintenance of blood-brain barrier biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
ACTG1 actin gamma 1
CDH5 cadherin 5, type 2 (vascular endothelium)
CLDN1 claudin 1
CLDN12 claudin 12
CLDN3 claudin 3
CLDN5 claudin 5
DMD dystrophin
ESAM endothelial cell adhesion molecule
F11R F11 receptor
GJA1 gap junction protein, alpha 1, 43kDa
GJB6 gap junction protein, beta 6, 30kDa
IL6 interleukin 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAM2 junctional adhesion molecule 2
JAM3 junctional adhesion molecule 3
LAMA2 laminin, alpha 2
LAMC1 laminin, gamma 1 (formerly LAMB2)
LSR lipolysis stimulated lipoprotein receptor
MFSD2A major facilitator superfamily domain containing 2A
OCLN occludin
PECAM1 platelet/endothelial cell adhesion molecule 1
POTEF POTE ankyrin domain family, member F
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TJP3 tight junction protein 3
VCL vinculin
WNK3 WNK lysine deficient protein kinase 3