major depressive disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities. (Human Disease Ontology, DOID_1470)
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50 genes co-occuring with the disease major depressive disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DISC1 disrupted in schizophrenia 1 1.80247
PI4K2B phosphatidylinositol 4-kinase type 2 beta 1.64218
ZNF80 zinc finger protein 80 1.51325
RNF123 ring finger protein 123 1.39695
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 1.36291
ALG9 ALG9, alpha-1,2-mannosyltransferase 1.3494
TSNAX translin-associated factor X 1.1456
CHRM2 cholinergic receptor, muscarinic 2 1.13585
AVPR1B arginine vasopressin receptor 1B 1.10048
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 1.0627
TOR1A torsin family 1, member A (torsin A) 1.0168
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 1.0168
CRHBP corticotropin releasing hormone binding protein 0.998236
MAOA monoamine oxidase A 0.944938
NDEL1 nudE neurodevelopment protein 1-like 1 0.838885
PDE4B phosphodiesterase 4B, cAMP-specific 0.768801
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 0.757378
NKX2-2 NK2 homeobox 2 0.74883
SGSH N-sulfoglucosamine sulfohydrolase 0.748017
SYNE1 spectrin repeat containing, nuclear envelope 1 0.735433
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.724502
CLOCK clock circadian regulator 0.705144
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit 0.693499
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.613574
CRH corticotropin releasing hormone 0.610448
EFS embryonal Fyn-associated substrate 0.571884
BDNF brain-derived neurotrophic factor 0.571107
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.541605
PRSS21 protease, serine, 21 (testisin) 0.538506
DRD4 dopamine receptor D4 0.511496
BPI bactericidal/permeability-increasing protein 0.503824
DRD3 dopamine receptor D3 0.483224
SOX10 SRY (sex determining region Y)-box 10 0.479427
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 0.457109
POLG polymerase (DNA directed), gamma 0.454847
CCL11 chemokine (C-C motif) ligand 11 0.410161
TPH1 tryptophan hydroxylase 1 0.406051
NRG1 neuregulin 1 0.394118
FOXP2 forkhead box P2 0.372587
FGD1 FYVE, RhoGEF and PH domain containing 1 0.325552
IDO1 indoleamine 2,3-dioxygenase 1 0.310652
FLNA filamin A, alpha 0.305226
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.290462
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.271174
CCL5 chemokine (C-C motif) ligand 5 0.260891
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.257711
PRRC2A proline-rich coiled-coil 2A 0.245396
NOS2 nitric oxide synthase 2, inducible 0.219398
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.219057
NPY neuropeptide Y 0.164571