| Dataset | DISEASES Experimental Gene-Disease Association Evidence Scores |
| Category | disease or phenotype associations |
| Type | disease |
| Description | A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.|Malaria is a parasitic disease characterized as a vector-borne arthropod infectious acute or chronic disease caused by the presence of sporozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. Occurrance is widespread in tropical and subtropical regions, including parts of the Americas, Asia, and Africa.|A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia.|An Aconoidasida infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (Experimental Factor Ontology, EFO_0001068) |
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30 genes associated with the disease malaria in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HBD | hemoglobin, delta | 1.70133 |
| HBB | hemoglobin, beta | 1.70133 |
| ABO | ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) | 1.41921 |
| OR51F1 | olfactory receptor, family 51, subfamily F, member 1 (gene/pseudogene) | 1.14929 |
| MMP26 | matrix metallopeptidase 26 | 1.14929 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.978353 |
| OR51V1 | olfactory receptor, family 51, subfamily V, member 1 | 0.7623 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.69843 |
| ARHGAP20 | Rho GTPase activating protein 20 | 0.414708 |
| ASB17 | ankyrin repeat and SOCS box containing 17 | 0.327313 |
| LOC648987 | uncharacterized LOC648987 | 0.327313 |
| CDH13 | cadherin 13 | 0.311576 |
| SPATA3 | spermatogenesis associated 3 | 0.311576 |
| RPL10L | ribosomal protein L10-like | 0.297866 |
| POMGNT2 | protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) | 0.274608 |
| ZNF804A | zinc finger protein 804A | 0.256228 |
| RGS2 | regulator of G-protein signaling 2 | 0.197766 |
| MARVELD3 | MARVEL domain containing 3 | 0.197766 |
| C3ORF70 | chromosome 3 open reading frame 70 | 0.15771 |
| HBE1 | hemoglobin, epsilon 1 | 0.100789 |
| HBG2 | hemoglobin, gamma G | 0.100789 |
| TMEM64 | transmembrane protein 64 | 0.080593 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.080593 |
| DDC | dopa decarboxylase (aromatic L-amino acid decarboxylase) | 0.080593 |
| NR1I2 | nuclear receptor subfamily 1, group I, member 2 | 0.064973 |
| OR51E2 | olfactory receptor, family 51, subfamily E, member 2 | 0.064973 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 0.064973 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 0.043246 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | 0.035343 |
| DIS3L2 | DIS3 like 3'-5' exoribonuclease 2 | 0.035343 |
