malaria Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.|Malaria is a parasitic disease characterized as a vector-borne arthropod infectious acute or chronic disease caused by the presence of sporozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. Occurrance is widespread in tropical and subtropical regions, including parts of the Americas, Asia, and Africa.|A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia.|An Aconoidasida infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (Experimental Factor Ontology, EFO_0001068)
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Genes

55 genes associated with the disease malaria in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
AIF1 allograft inflammatory factor 1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
CD36 CD36 molecule (thrombospondin receptor)
CD40LG CD40 ligand
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
G6PD glucose-6-phosphate dehydrogenase
GNAS GNAS complex locus
GYPC glycophorin C (Gerbich blood group)
HBB hemoglobin, beta
HFE hemochromatosis
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
ICAM1 intercellular adhesion molecule 1
IFNA1 interferon, alpha 1
IFNA2 interferon, alpha 2
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IL10 interleukin 10
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
LST1 leukocyte specific transcript 1
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
MBL2 mannose-binding lectin (protein C) 2, soluble
MICB MHC class I polypeptide-related sequence B
NCR3 natural cytotoxicity triggering receptor 3
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOS1 nitric oxide synthase 1 (neuronal)
NOS2 nitric oxide synthase 2, inducible
PECAM1 platelet/endothelial cell adhesion molecule 1
PRRC2A proline-rich coiled-coil 2A
SCO1 SCO1 cytochrome c oxidase assembly protein
SELE selectin E
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TPI1 triosephosphate isomerase 1
XK X-linked Kx blood group