malaria Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.|Malaria is a parasitic disease characterized as a vector-borne arthropod infectious acute or chronic disease caused by the presence of sporozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. Occurrance is widespread in tropical and subtropical regions, including parts of the Americas, Asia, and Africa.|A protozoan infection caused by the genus Plasmodium. There are four species of Plasmodium that can infect humans: Plasmodium falciparum, vivax, ovale, and malariae. It is transmitted to humans by infected mosquitoes. Signs and symptoms include paroxysmal high fever, sweating, chills, and anemia.|An Aconoidasida infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. (Experimental Factor Ontology, EFO_0001068)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:12365
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Genes

46 genes associated with the disease malaria in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HBB hemoglobin, beta 2.39945
OR51F1 olfactory receptor, family 51, subfamily F, member 1 (gene/pseudogene) 1.86468
OR51B5 olfactory receptor, family 51, subfamily B, member 5 1.75142
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.67948
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 1.55738
CDH13 cadherin 13 1.24194
POMGNT2 protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) 1.21392
ZNF804A zinc finger protein 804A 1.19386
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.02476
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.00788
OR51E2 olfactory receptor, family 51, subfamily E, member 2 1.00221
MAST2 microtubule associated serine/threonine kinase 2 0.965779
DIS3L2 DIS3 like 3'-5' exoribonuclease 2 0.958374
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.958374
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.947208
PLXNA4 plexin A4 0.947208
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 0.928472
PARK2 parkin RBR E3 ubiquitin protein ligase 0.920453
PLEKHA6 pleckstrin homology domain containing, family A member 6 0.920453
FAM53B family with sequence similarity 53, member B 0.905653
CIAPIN1 cytokine induced apoptosis inhibitor 1 0.853791
MAML2 mastermind-like 2 (Drosophila) 0.839855
STON2 stonin 2 0.839855
WWOX WW domain containing oxidoreductase 0.82729
MTMR10 myotubularin related protein 10 0.808055
MEIS1 Meis homeobox 1 0.808055
ARHGAP26 Rho GTPase activating protein 26 0.804621
HNMT histamine N-methyltransferase 0.801304
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 0.790866
STAC SH3 and cysteine rich domain 0.78442
TSHZ2 teashirt zinc finger homeobox 2 0.78442
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1 0.764084
OR13D1 olfactory receptor, family 13, subfamily D, member 1 0.74095
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.724858
GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3 0.722673
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.712368
LOC648987 uncharacterized LOC648987 0.708508
RYR2 ryanodine receptor 2 (cardiac) 0.701191
ZNF329 zinc finger protein 329 0.701191
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.696042
OPCML opioid binding protein/cell adhesion molecule-like 0.692747
LOC400927 TPTE and PTEN homologous inositol lipid phosphatase pseudogene 0.691138
LINC01587 long intergenic non-protein coding RNA 1587 0.689554
DCLK1 doublecortin-like kinase 1 0.677699
DEPTOR DEP domain containing MTOR-interacting protein 0.659337
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 0.505894