march2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase|MARCH2 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH2 reduces surface accumulation of several glycoproteins and appears to regulate early endosome-to-trans-Golgi network (TGN) trafficking (Bartee et al., 2004 [PubMed 14722266]; Nakamura et al., 2005 [PubMed 15689499]).[supplied by OMIM, Mar 2010] (NCBI Entrez Gene Database, 51257)
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Genes

5 genes co-occuring with the biological term march2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
DLG1 discs, large homolog 1 (Drosophila)
GOPC golgi-associated PDZ and coiled-coil motif containing
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
STX6 syntaxin 6