| Dataset | GO Biological Process Annotations 2025 |
| Category | structural or functional annotations |
| Type | biological process |
| Description | The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL). (Gene Ontology, GO_0002315) |
| External Link | http://amigo.geneontology.org/amigo/term/GO:0002315 |
| Similar Terms | |
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7 genes participating in the marginal zone B cell differentiation biological process from the curated GO Biological Process Annotations 2025 dataset.
