mcc Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. (Gene Ontology, GO_0033597)
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Genes

20 genes co-occuring with the biological term mcc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
APC adenomatous polyposis coli
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CD274 CD274 molecule
CDC20 cell division cycle 20
CDKN2A cyclin-dependent kinase inhibitor 2A
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
FLI1 Fli-1 proto-oncogene, ETS transcription factor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L1BP MAD2L1 binding protein
MCC mutated in colorectal cancers
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha)
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MYC v-myc avian myelocytomatosis viral oncogene homolog
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
SCRIB scribbled planar cell polarity protein
TP53 tumor protein p53
TRIP13 thyroid hormone receptor interactor 13
WNT5A wingless-type MMTV integration site family, member 5A