mdm2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description MDM2 proto-oncogene, E3 ubiquitin protein ligase|This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 4193)
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Genes

229 genes co-occuring with the biological term mdm2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALK anaplastic lymphoma receptor tyrosine kinase
ANAPC2 anaphase promoting complex subunit 2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOC3 apolipoprotein C-III
AR androgen receptor
ARF1 ADP-ribosylation factor 1
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
ARL11 ADP-ribosylation factor-like 11
ARR3 arrestin 3, retinal (X-arrestin)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATM ATM serine/threonine kinase
AURKA aurora kinase A
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BIRC3 baculoviral IAP repeat containing 3
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK9 cyclin-dependent kinase 9
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDX2 caudal type homeobox 2
CEP164 centrosomal protein 164kDa
CHEK2 checkpoint kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
COPS5 COP9 signalosome subunit 5
CREB1 cAMP responsive element binding protein 1
CSNK1A1 casein kinase 1, alpha 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTSB cathepsin B
DAXX death-domain associated protein
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DHFR dihydrofolate reductase
DMD dystrophin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSC1 desmocollin 1
DSC2 desmocollin 2
DSC3 desmocollin 3
E2F1 E2F transcription factor 1
EGFR epidermal growth factor receptor
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF4E eukaryotic translation initiation factor 4E
EP300 E1A binding protein p300
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR2 estrogen receptor 2 (ER beta)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM3B family with sequence similarity 3, member B
FGFR3 fibroblast growth factor receptor 3
FHIT fragile histidine triad
FKBP3 FK506 binding protein 3, 25kDa
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FUBP1 far upstream element (FUSE) binding protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GLI1 GLI family zinc finger 1
GMCL1 germ cell-less, spermatogenesis associated 1
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like
GSK3B glycogen synthase kinase 3 beta
GTSE1 G-2 and S-phase expressed 1
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HMGA2 high mobility group AT-hook 2
HNRNPK heterogeneous nuclear ribonucleoprotein K
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
IGF1R insulin-like growth factor 1 receptor
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ITCH itchy E3 ubiquitin protein ligase
JAK2 Janus kinase 2
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
MAPK10 mitogen-activated protein kinase 10
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED1 mediator complex subunit 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR143 microRNA 143
MIR145 microRNA 145
MIR17 microRNA 17
MIR192 microRNA 192
MIR194-1 microRNA 194-1
MIR215 microRNA 215
MIR34B microRNA 34b
MIR605 microRNA 605
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MMP9 matrix metallopeptidase 9
MTBP MDM2 binding protein
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NBN nibrin
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NKX2-1 NK2 homeobox 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTN1 netrin 1
NUMB numb homolog (Drosophila)
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM7 PDZ and LIM domain 7 (enigma)
PIAS1 protein inhibitor of activated STAT, 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PITX1 paired-like homeodomain 1
PLK1 polo-like kinase 1
PML promyelocytic leukemia
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLH polymerase (DNA directed), eta
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51 RAD51 recombinase
RANBP2 RAN binding protein 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF6 Ras association (RalGDS/AF-6) domain family member 6
RB1 retinoblastoma 1
RBM38 RNA binding motif protein 38
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
REST RE1-silencing transcription factor
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RFWD3 ring finger and WD repeat domain 3
RNF34 ring finger protein 34, E3 ubiquitin protein ligase
RPL11 ribosomal protein L11
RPL26 ribosomal protein L26
RPL29 ribosomal protein L29
RPL30 ribosomal protein L30
RPL5 ribosomal protein L5
RPS27 ribosomal protein S27
RPS27A ribosomal protein S27a
RPS3 ribosomal protein S3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPS7 ribosomal protein S7
RYBP RING1 and YY1 binding protein
S100A1 S100 calcium binding protein A1
S100A2 S100 calcium binding protein A2
S100A4 S100 calcium binding protein A4
S100A6 S100 calcium binding protein A6
S100B S100 calcium binding protein B
SCYL1 SCY1-like 1 (S. cerevisiae)
SDC4 syndecan 4
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SENP8 SUMO/sentrin specific peptidase family member 8
SFN stratifin
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
SGK1 serum/glucocorticoid regulated kinase 1
SIRT2 sirtuin 2
SIRT3 sirtuin 3
SKI SKI proto-oncogene
SMO smoothened, frizzled class receptor
SNAI2 snail family zinc finger 2
SSB Sjogren syndrome antigen B (autoantigen La)
STX6 syntaxin 6
SUMO1 small ubiquitin-like modifier 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TBRG1 transforming growth factor beta regulator 1
TGFB1 transforming growth factor, beta 1
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
TRIM13 tripartite motif containing 13
TRIM5 tripartite motif containing 5
TRIM8 tripartite motif containing 8
TRRAP transformation/transcription domain-associated protein
TSG101 tumor susceptibility 101
TSPAN31 tetraspanin 31
UBC ubiquitin C
UBE2A ubiquitin-conjugating enzyme E2A
UBE2B ubiquitin-conjugating enzyme E2B
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP2 ubiquitin specific peptidase 2
USP22 ubiquitin specific peptidase 22
USP33 ubiquitin specific peptidase 33
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VEGFA vascular endothelial growth factor A
XPC xeroderma pigmentosum, complementation group C
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YY1 YY1 transcription factor
ZKSCAN4 zinc finger with KRAB and SCAN domains 4