mdm2 Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description MDM2 proto-oncogene, E3 ubiquitin protein ligase|This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 4193)
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Genes

64 proteins co-occuring with the biological term mdm2 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKT1 v-akt murine thymoma viral oncogene homolog 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARRB1 arrestin, beta 1
ATM ATM serine/threonine kinase
BCL2 B-cell CLL/lymphoma 2
CCND1 cyclin D1
CDC25C cell division cycle 25C
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHEK1 checkpoint kinase 1
COPS6 COP9 signalosome subunit 6
CREBBP CREB binding protein
DAXX death-domain associated protein
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EGFR epidermal growth factor receptor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ESR2 estrogen receptor 2 (ER beta)
FAM129A family with sequence similarity 129, member A
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H2AFX H2A histone family, member X
HSPB1 heat shock 27kDa protein 1
JUN jun proto-oncogene
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MET MET proto-oncogene, receptor tyrosine kinase
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCA protein kinase C, alpha
PTEN phosphatase and tensin homolog
RB1 retinoblastoma 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFWD2 ring finger and WD repeat domain 2, E3 ubiquitin protein ligase
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SMAD3 SMAD family member 3
SSB Sjogren syndrome antigen B (autoantigen La)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STRAP serine/threonine kinase receptor associated protein
TP53 tumor protein p53
TP73 tumor protein p73
TTC5 tetratricopeptide repeat domain 5
TXN thioredoxin
USP10 ubiquitin specific peptidase 10
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WWOX WW domain containing oxidoreductase