mds Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Myelodysplastic syndromes are a class of syndromes which involve ineffective production (or dysplasia) of the myeloid class of blood cells.|A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001) (Experimental Factor Ontology, EFO_0000198)
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Genes

125 genes co-occuring with the biological term mds in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ARHGAP26 Rho GTPase activating protein 26
ASXL1 additional sex combs like transcriptional regulator 1
BCOR BCL6 corepressor
BCORL1 BCL6 corepressor-like 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CALCA calcitonin-related polypeptide alpha
CALR calreticulin
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CD19 CD19 molecule
CD33 CD33 molecule
CD34 CD34 molecule
CD47 CD47 molecule
CD52 CD52 molecule
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DAPK1 death-associated protein kinase 1
DICER1 dicer 1, ribonuclease type III
DLK1 delta-like 1 homolog (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DROSHA drosha, ribonuclease type III
EIF4E eukaryotic translation initiation factor 4E
EPO erythropoietin
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAS Fas cell surface death receptor
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FGF2 fibroblast growth factor 2 (basic)
FHIT fragile histidine triad
FLT3 fms-related tyrosine kinase 3
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GATA1 GATA binding protein 1 (globin transcription factor 1)
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAMP hepcidin antimicrobial peptide
HFE hemochromatosis
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HOXD13 homeobox D13
HRAS Harvey rat sarcoma viral oncogene homolog
ICAM1 intercellular adhesion molecule 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IL10 interleukin 10
IL3RA interleukin 3 receptor, alpha (low affinity)
IL6 interleukin 6
IRF8 interferon regulatory factor 8
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK2 Janus kinase 2
KLF11 Kruppel-like factor 11
KMT2A lysine (K)-specific methyltransferase 2A
LIG4 ligase IV, DNA, ATP-dependent
MCM2 minichromosome maintenance complex component 2
MECOM MDS1 and EVI1 complex locus
MEFV Mediterranean fever
MEG3 maternally expressed 3 (non-protein coding)
MIR10A microRNA 10a
MIR10B microRNA 10b
MIR125B1 microRNA 125b-1
MIR15A microRNA 15a
MIR16-1 microRNA 16-1
MIR181A1 microRNA 181a-1
MIR222 microRNA 222
MLF1 myeloid leukemia factor 1
MMP9 matrix metallopeptidase 9
MN1 meningioma (disrupted in balanced translocation) 1
MPV17 MpV17 mitochondrial inner membrane protein
MVP major vault protein
NGFR nerve growth factor receptor
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NT5C2 5'-nucleotidase, cytosolic II
NUP98 nucleoporin 98kDa
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PF4 platelet factor 4
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPA2 pyrophosphatase (inorganic) 2
PPARG peroxisome proliferator-activated receptor gamma
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRAME preferentially expressed antigen in melanoma
PRDM2 PR domain containing 2, with ZNF domain
PSIP1 PC4 and SFRS1 interacting protein 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAD51 RAD51 recombinase
RING1 ring finger protein 1
RPL23 ribosomal protein L23
RPS14 ribosomal protein S14
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX1 runt-related transcription factor 1
SALL4 spalt-like transcription factor 4
SBDS Shwachman-Bodian-Diamond syndrome
SELL selectin L
SETBP1 SET binding protein 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFRP1 secreted frizzled-related protein 1
SNRPN small nuclear ribonucleoprotein polypeptide N
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRSF2 serine/arginine-rich splicing factor 2
TERT telomerase reverse transcriptase
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
THPO thrombopoietin
TJP1 tight junction protein 1
TK2 thymidine kinase 2, mitochondrial
TLR2 toll-like receptor 2
TNF tumor necrosis factor
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TRA T cell receptor alpha locus
TRB T cell receptor beta locus
TWIST1 twist family bHLH transcription factor 1
U2AF1 U2 small nuclear RNA auxiliary factor 1
VEGFA vascular endothelial growth factor A
WNT1 wingless-type MMTV integration site family, member 1
WT1 Wilms tumor 1
YBX1 Y box binding protein 1