mebendazole-2338 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the mebendazole-2338 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ANXA2 annexin A2
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
BCL3 B-cell CLL/lymphoma 3
BTG2 BTG family, member 2
C3AR1 complement component 3a receptor 1
CCL20 chemokine (C-C motif) ligand 20
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD83 CD83 molecule
CD86 CD86 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP72 centrosomal protein 72kDa
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CREM cAMP responsive element modulator
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DOCK4 dedicator of cytokinesis 4
EGR1 early growth response 1
EMP1 epithelial membrane protein 1
FAM114A1 family with sequence similarity 114, member A1
FLOT1 flotillin 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FMNL1 formin-like 1
FPR1 formyl peptide receptor 1
FTH1 ferritin, heavy polypeptide 1
FTH1P5 ferritin, heavy polypeptide 1 pseudogene 5
G0S2 G0/G1 switch 2
GAS7 growth arrest-specific 7
GBP2 guanylate binding protein 2, interferon-inducible
H2BFS H2B histone family, member S (pseudogene)
HBEGF heparin-binding EGF-like growth factor
HRH1 histamine receptor H1
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
IL10RA interleukin 10 receptor, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1RN interleukin 1 receptor antagonist
IL4R interleukin 4 receptor
KLF10 Kruppel-like factor 10
KYNU kynureninase
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LIMD2 LIM domain containing 2
LPAR6 lysophosphatidic acid receptor 6
LTB lymphotoxin beta (TNF superfamily, member 3)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARK4 MAP/microtubule affinity-regulating kinase 4
MCTP2 multiple C2 domains, transmembrane 2
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MTMR11 myotubularin related protein 11
NDE1 nudE neurodevelopment protein 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM7 PDZ and LIM domain 7 (enigma)
PLAUR plasminogen activator, urokinase receptor
PLSCR1 phospholipid scramblase 1
PPARD peroxisome proliferator-activated receptor delta
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
PTPRE protein tyrosine phosphatase, receptor type, E
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SGK1 serum/glucocorticoid regulated kinase 1
SH2B3 SH2B adaptor protein 3
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMOX spermine oxidase
SSH1 slingshot protein phosphatase 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TLE3 transducin-like enhancer of split 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM194A transmembrane protein 194A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM4 tropomyosin 4
TRA T cell receptor alpha locus
TRAC T cell receptor alpha constant
TREM1 triggering receptor expressed on myeloid cells 1
TTLL3 tubulin tyrosine ligase-like family member 3
YPEL5 yippee-like 5 (Drosophila)
ZCCHC24 zinc finger, CCHC domain containing 24
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADGRA3 adhesion G protein-coupled receptor A3
ADRB2 adrenoceptor beta 2, surface
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
BAG2 BCL2-associated athanogene 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIK BCL2-interacting killer (apoptosis-inducing)
C2CD2 C2 calcium-dependent domain containing 2
CCDC86 coiled-coil domain containing 86
CCR2 chemokine (C-C motif) receptor 2
CD320 CD320 molecule
CEP70 centrosomal protein 70kDa
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CLTCL1 clathrin, heavy chain-like 1
COA7 cytochrome c oxidase assembly factor 7 (putative)
DCTPP1 dCTP pyrophosphatase 1
DDN dendrin
DENND4A DENN/MADD domain containing 4A
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DLEU2 deleted in lymphocytic leukemia 2 (non-protein coding)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ERLIN1 ER lipid raft associated 1
EXOSC5 exosome component 5
FAM46A family with sequence similarity 46, member A
FAM86B1 family with sequence similarity 86, member B1
FARSA phenylalanyl-tRNA synthetase, alpha subunit
FLT3 fms-related tyrosine kinase 3
GPR63 G protein-coupled receptor 63
HILPDA hypoxia inducible lipid droplet-associated
HSPA4L heat shock 70kDa protein 4-like
IRF8 interferon regulatory factor 8
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0930 KIAA0930
LAMP5 lysosomal-associated membrane protein family, member 5
LRP3 low density lipoprotein receptor-related protein 3
MAGOHB mago-nashi homolog B (Drosophila)
METTL1 methyltransferase like 1
METTL8 methyltransferase like 8
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MON1B MON1 secretory trafficking family member B
MPI mannose phosphate isomerase
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MYBBP1A MYB binding protein (P160) 1a
MYC v-myc avian myelocytomatosis viral oncogene homolog
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative)
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NAT10 N-acetyltransferase 10 (GCN5-related)
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NPM3 nucleophosmin/nucleoplasmin 3
NTHL1 nth endonuclease III-like 1 (E. coli)
NUBPL nucleotide binding protein-like
ODC1 ornithine decarboxylase 1
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFAS phosphoribosylformylglycinamidine synthase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB4 phospholipase C, beta 4
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
POR P450 (cytochrome) oxidoreductase
PRTN3 proteinase 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PUS7 pseudouridylate synthase 7 (putative)
QTRT1 queuine tRNA-ribosyltransferase 1
RPP40 ribonuclease P/MRP 40kDa subunit
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SEH1L SEH1-like (S. cerevisiae)
SERPINB10 serpin peptidase inhibitor, clade B (ovalbumin), member 10
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLIRP SRA stem-loop interacting RNA binding protein
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRM spermidine synthase
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STAR steroidogenic acute regulatory protein
TERT telomerase reverse transcriptase
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TMEM177 transmembrane protein 177
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TUBA4A tubulin, alpha 4a
TUBB4B tubulin, beta 4B class IVb
UBIAD1 UbiA prenyltransferase domain containing 1
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR12 WD repeat domain 12
WDR3 WD repeat domain 3
WNT10B wingless-type MMTV integration site family, member 10B
ZNF250 zinc finger protein 250
ZNF37BP zinc finger protein 37B, pseudogene
ZNHIT2 zinc finger, HIT-type containing 2