mebhydrolin-1333 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the mebhydrolin-1333 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ACOX3 acyl-CoA oxidase 3, pristanoyl
ADRBK1 adrenergic, beta, receptor kinase 1
AEN apoptosis enhancing nuclease
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKRD26 ankyrin repeat domain 26
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
AXIN1 axin 1
B3GNT1
BBS9 Bardet-Biedl syndrome 9
BEST1 bestrophin 1
BMP1 bone morphogenetic protein 1
BMP15 bone morphogenetic protein 15
BTBD7 BTB (POZ) domain containing 7
C17ORF59 chromosome 17 open reading frame 59
C1ORF56 chromosome 1 open reading frame 56
CA11 carbonic anhydrase XI
CPQ carboxypeptidase Q
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
DOC2A double C2-like domains, alpha
DPH5 diphthamide biosynthesis 5
ECE1 endothelin converting enzyme 1
FAM168A family with sequence similarity 168, member A
FAM3A family with sequence similarity 3, member A
FAS Fas cell surface death receptor
FBXL18 F-box and leucine-rich repeat protein 18
FER fer (fps/fes related) tyrosine kinase
FNTB farnesyltransferase, CAAX box, beta
GABARAPL1 GABA(A) receptor-associated protein like 1
GLP1R glucagon-like peptide 1 receptor
GLTSCR1L GLTSCR1-like
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRIP2 glutamate receptor interacting protein 2
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HGH1 HGH1 homolog (S. cerevisiae)
HNRNPR heterogeneous nuclear ribonucleoprotein R
IFFO1 intermediate filament family orphan 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IQCK IQ motif containing K
ITGB5 integrin, beta 5
KIR3DX1 killer cell immunoglobulin-like receptor, three domains, X1
KPTN kaptin (actin binding protein)
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LMNA lamin A/C
LOC729164 hCG1732469
LPPR3 lipid phosphate phosphatase-related protein type 3
LRP2 low density lipoprotein receptor-related protein 2
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARCKS myristoylated alanine-rich protein kinase C substrate
MAST2 microtubule associated serine/threonine kinase 2
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MIIP migration and invasion inhibitory protein
MLF1 myeloid leukemia factor 1
MMP19 matrix metallopeptidase 19
MTHFS 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
MTUS1 microtubule associated tumor suppressor 1
NF1 neurofibromin 1
OGG1 8-oxoguanine DNA glycosylase
OTUD4 OTU deubiquitinase 4
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4
PLCL2 phospholipase C-like 2
PLSCR3 phospholipid scramblase 3
PMP22 peripheral myelin protein 22
PTCRA pre T-cell antigen receptor alpha
PXN paxillin
RAB11B RAB11B, member RAS oncogene family
RASA3 RAS p21 protein activator 3
RFXAP regulatory factor X-associated protein
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RNFT1 ring finger protein, transmembrane 1
RPS14 ribosomal protein S14
S100A11 S100 calcium binding protein A11
SCAI suppressor of cancer cell invasion
SIK3 SIK family kinase 3
SLC22A14 solute carrier family 22, member 14
SMYD2 SET and MYND domain containing 2
SNW1 SNW domain containing 1
SOS2 son of sevenless homolog 2 (Drosophila)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TMPRSS15 transmembrane protease, serine 15
TRIP11 thyroid hormone receptor interactor 11
TSC22D4 TSC22 domain family, member 4
TUBB3 tubulin, beta 3 class III
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
UCN urocortin
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
WDR33 WD repeat domain 33
WDR5B WD repeat domain 5B
ZHX2 zinc fingers and homeoboxes 2
ZNF219 zinc finger protein 219
ZNF254 zinc finger protein 254
ZNF783 zinc finger family member 783
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD11 ankyrin repeat domain 11
ANKRD55 ankyrin repeat domain 55
ANXA2P2 annexin A2 pseudogene 2
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATAD3A ATPase family, AAA domain containing 3A
ATG4A autophagy related 4A, cysteine peptidase
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BLVRB biliverdin reductase B
BTBD2 BTB (POZ) domain containing 2
C11ORF30 chromosome 11 open reading frame 30
C7ORF43 chromosome 7 open reading frame 43
CARM1 coactivator-associated arginine methyltransferase 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CEP83 centrosomal protein 83kDa
CGREF1 cell growth regulator with EF-hand domain 1
CINP cyclin-dependent kinase 2 interacting protein
CIR1 corepressor interacting with RBPJ, 1
DCPS decapping enzyme, scavenger
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DGAT1 diacylglycerol O-acyltransferase 1
DNAL4 dynein, axonemal, light chain 4
ERCC2 excision repair cross-complementation group 2
ERO1LB ERO1-like beta (S. cerevisiae)
FAM102A family with sequence similarity 102, member A
FAM50B family with sequence similarity 50, member B
FASTKD5 FAST kinase domains 5
FHIT fragile histidine triad
FIP1L1 factor interacting with PAPOLA and CPSF1
FOXN2 forkhead box N2
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GCH1 GTP cyclohydrolase 1
GEMIN8 gem (nuclear organelle) associated protein 8
GPR35 G protein-coupled receptor 35
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BI histone cluster 1, H2bi
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HP haptoglobin
HPSE heparanase
INPP1 inositol polyphosphate-1-phosphatase
ISOC2 isochorismatase domain containing 2
KAT2A K(lysine) acetyltransferase 2A
KIAA0556 KIAA0556
LIG1 ligase I, DNA, ATP-dependent
MAPK3 mitogen-activated protein kinase 3
MCRS1 microspherule protein 1
MIR22HG MIR22 host gene
NMB neuromedin B
NPDC1 neural proliferation, differentiation and control, 1
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAQR6 progestin and adipoQ receptor family member VI
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PNPLA6 patatin-like phospholipase domain containing 6
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTDSS2 phosphatidylserine synthase 2
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
RAB17 RAB17, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RBM42 RNA binding motif protein 42
RETN resistin
RNF121 ring finger protein 121
RNF141 ring finger protein 141
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
SALL2 spalt-like transcription factor 2
SCD5 stearoyl-CoA desaturase 5
SETD8 SET domain containing (lysine methyltransferase) 8
SKI SKI proto-oncogene
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SMA4 glucuronidase, beta pseudogene
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
STAG3 stromal antigen 3
TESC tescalcin
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM14A transmembrane protein 14A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRAPPC2 trafficking protein particle complex 2
TRIM26 tripartite motif containing 26
TRMT12 tRNA methyltransferase 12 homolog (S. cerevisiae)
TRPS1 trichorhinophalangeal syndrome I
TSPAN14 tetraspanin 14
TSPYL2 TSPY-like 2
TTC4 tetratricopeptide repeat domain 4
TUBA3C tubulin, alpha 3c
UBE2O ubiquitin-conjugating enzyme E2O
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
WDR46 WD repeat domain 46
XAB2 XPA binding protein 2
ZC3H3 zinc finger CCCH-type containing 3
ZNF250 zinc finger protein 250
ZNF552 zinc finger protein 552
ZNF675 zinc finger protein 675
ZNF816 zinc finger protein 816