meclocycline-1341 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the meclocycline-1341 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ADGB androglobin
AKAP13 A kinase (PRKA) anchor protein 13
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
AP4S1 adaptor-related protein complex 4, sigma 1 subunit
ASB8 ankyrin repeat and SOCS box containing 8
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAHCC1 BAH domain and coiled-coil containing 1
BBS7 Bardet-Biedl syndrome 7
BBS9 Bardet-Biedl syndrome 9
BRAF B-Raf proto-oncogene, serine/threonine kinase
C16ORF59 chromosome 16 open reading frame 59
C22ORF29 chromosome 22 open reading frame 29
CACTIN cactin, spliceosome C complex subunit
CCDC22 coiled-coil domain containing 22
CCSER2 coiled-coil serine-rich protein 2
CLEC16A C-type lectin domain family 16, member A
CPT1A carnitine palmitoyltransferase 1A (liver)
CYB561 cytochrome b561
CYHR1 cysteine/histidine-rich 1
DBT dihydrolipoamide branched chain transacylase E2
DESI2 desumoylating isopeptidase 2
DLG4 discs, large homolog 4 (Drosophila)
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DTNA dystrobrevin, alpha
DUSP3 dual specificity phosphatase 3
EIF5 eukaryotic translation initiation factor 5
EXOC7 exocyst complex component 7
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
GPR19 G protein-coupled receptor 19
GPR27 G protein-coupled receptor 27
HIF1AN hypoxia inducible factor 1, alpha subunit inhibitor
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
ICK intestinal cell (MAK-like) kinase
IDS iduronate 2-sulfatase
IGL immunoglobulin lambda locus
IL13RA1 interleukin 13 receptor, alpha 1
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
JUND jun D proto-oncogene
KATNB1 katanin p80 (WD repeat containing) subunit B 1
KCNK5 potassium channel, two pore domain subfamily K, member 5
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF3C kinesin family member 3C
KLF2 Kruppel-like factor 2
KRAS Kirsten rat sarcoma viral oncogene homolog
LAMP1 lysosomal-associated membrane protein 1
LMNA lamin A/C
LZTR1 leucine-zipper-like transcription regulator 1
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK14 mitogen-activated protein kinase 14
MBTPS1 membrane-bound transcription factor peptidase, site 1
MED27 mediator complex subunit 27
MFAP3 microfibrillar-associated protein 3
MSL3 male-specific lethal 3 homolog (Drosophila)
MT1HL1 metallothionein 1H-like 1
N4BP2L2 NEDD4 binding protein 2-like 2
NCS1 neuronal calcium sensor 1
NLRP3 NLR family, pyrin domain containing 3
NMT1 N-myristoyltransferase 1
OGG1 8-oxoguanine DNA glycosylase
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDGFD platelet derived growth factor D
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PSEN1 presenilin 1
PSPH phosphoserine phosphatase
PTBP3 polypyrimidine tract binding protein 3
PTK2B protein tyrosine kinase 2 beta
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB6A RAB6A, member RAS oncogene family
RANBP10 RAN binding protein 10
RIPK2 receptor-interacting serine-threonine kinase 2
SCAI suppressor of cancer cell invasion
SCAPER S-phase cyclin A-associated protein in the ER
SCARB1 scavenger receptor class B, member 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
SP110 SP110 nuclear body protein
SRR serine racemase
SS18 synovial sarcoma translocation, chromosome 18
STAT5A signal transducer and activator of transcription 5A
TLR8 toll-like receptor 8
TRMT61A tRNA methyltransferase 61A
TSC22D3 TSC22 domain family, member 3
TSC22D4 TSC22 domain family, member 4
UBE2B ubiquitin-conjugating enzyme E2B
UBE2D4 ubiquitin-conjugating enzyme E2D 4 (putative)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WSB1 WD repeat and SOCS box containing 1
ZBTB20 zinc finger and BTB domain containing 20
ZNF580 zinc finger protein 580
ZNF609 zinc finger protein 609
ZSCAN16 zinc finger and SCAN domain containing 16

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABT1 activator of basal transcription 1
ADGRA3 adhesion G protein-coupled receptor A3
AHDC1 AT hook, DNA binding motif, containing 1
AIM2 absent in melanoma 2
ASAP1-IT1 ASAP1 intronic transcript 1
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BTBD18 BTB (POZ) domain containing 18
C19ORF24 chromosome 19 open reading frame 24
C1ORF21 chromosome 1 open reading frame 21
C2CD2 C2 calcium-dependent domain containing 2
CA5BP1 carbonic anhydrase VB pseudogene 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCNA1 cyclin A1
CD1D CD1d molecule
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLSPN claspin
COPS7B COP9 signalosome subunit 7B
CPPED1 calcineurin-like phosphoesterase domain containing 1
CRADD CASP2 and RIPK1 domain containing adaptor with death domain
CTSH cathepsin H
DCPS decapping enzyme, scavenger
DOLPP1 dolichyldiphosphatase 1
DUS1L dihydrouridine synthase 1-like (S. cerevisiae)
DUSP5 dual specificity phosphatase 5
DVL1 dishevelled segment polarity protein 1
DYM dymeclin
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
ELP6 elongator acetyltransferase complex subunit 6
FBXO46 F-box protein 46
FOSL1 FOS-like antigen 1
GLTP glycolipid transfer protein
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPALPP1 GPALPP motifs containing 1
GRAMD1B GRAM domain containing 1B
HIST1H4J histone cluster 1, H4j
HYAL3 hyaluronoglucosaminidase 3
IMPAD1 inositol monophosphatase domain containing 1
INF2 inverted formin, FH2 and WH2 domain containing
IRAK4 interleukin-1 receptor-associated kinase 4
IRF7 interferon regulatory factor 7
JRKL JRK-like
KPTN kaptin (actin binding protein)
LIMD2 LIM domain containing 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MANF mesencephalic astrocyte-derived neurotrophic factor
MAPK3 mitogen-activated protein kinase 3
MARCKSL1 MARCKS-like 1
MCRS1 microspherule protein 1
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MRGBP MRG/MORF4L binding protein
MRPL44 mitochondrial ribosomal protein L44
MRPS34 mitochondrial ribosomal protein S34
NMB neuromedin B
NOL6 nucleolar protein 6 (RNA-associated)
NPFFR1 neuropeptide FF receptor 1
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTHL1 nth endonuclease III-like 1 (E. coli)
NTSR1 neurotensin receptor 1 (high affinity)
NUBP1 nucleotide binding protein 1
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PARP16 poly (ADP-ribose) polymerase family, member 16
PHACTR1 phosphatase and actin regulator 1
PIDD1 p53-induced death domain protein 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PNPLA6 patatin-like phospholipase domain containing 6
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PRDM13 PR domain containing 13
PRRC1 proline-rich coiled-coil 1
PSENEN presenilin enhancer gamma secretase subunit
PSKH1 protein serine kinase H1
PUS3 pseudouridylate synthase 3
PYCR1 pyrroline-5-carboxylate reductase 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RNF126P1 ring finger protein 126 pseudogene 1
RNF7 ring finger protein 7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMYD5 SMYD family member 5
SNHG20 small nucleolar RNA host gene 20
SNIP1 Smad nuclear interacting protein 1
STAG3 stromal antigen 3
STK16 serine/threonine kinase 16
SYNJ2BP synaptojanin 2 binding protein
TCTN2 tectonic family member 2
THBS3 thrombospondin 3
THEM6 thioesterase superfamily member 6
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TMEM177 transmembrane protein 177
TMEM184B transmembrane protein 184B
TUBA3C tubulin, alpha 3c
UNG uracil-DNA glycosylase
ZW10 zw10 kinetochore protein