meclocycline-6637 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

193 genes differentially expressed following the meclocycline-6637 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACHE acetylcholinesterase (Yt blood group)
ACSM1 acyl-CoA synthetase medium-chain family member 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRB2 adhesion G protein-coupled receptor B2
ADRBK2 adrenergic, beta, receptor kinase 2
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATHL1 ATH1, acid trehalase-like 1 (yeast)
ATXN7L1 ataxin 7-like 1
BMP2 bone morphogenetic protein 2
BMP7 bone morphogenetic protein 7
BTG2 BTG family, member 2
C10ORF12 chromosome 10 open reading frame 12
C19ORF40 chromosome 19 open reading frame 40
C1QB complement component 1, q subcomponent, B chain
C22ORF24 chromosome 22 open reading frame 24
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD300A CD300a molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN6 chloride channel, voltage-sensitive 6
CLDN10 claudin 10
DGKQ diacylglycerol kinase, theta 110kDa
EMID1 EMI domain containing 1
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FABP3 fatty acid binding protein 3, muscle and heart
FAM46C family with sequence similarity 46, member C
FLT1 fms-related tyrosine kinase 1
FRZB frizzled-related protein
GLRA3 glycine receptor, alpha 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPR135 G protein-coupled receptor 135
HBB hemoglobin, beta
HOXC5 homeobox C5
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
IFI44 interferon-induced protein 44
IGHM immunoglobulin heavy constant mu
IL11 interleukin 11
ING2 inhibitor of growth family, member 2
ING4 inhibitor of growth family, member 4
JAK3 Janus kinase 3
JUND jun D proto-oncogene
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KDM4C lysine (K)-specific demethylase 4C
KLHL25 kelch-like family member 25
KRT23 keratin 23, type I
LAT2 linker for activation of T cells family, member 2
LIMD1 LIM domains containing 1
LMTK2 lemur tyrosine kinase 2
LOC157562 uncharacterized LOC157562
LOC202181 SUMO-interacting motifs containing 1 pseudogene
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCOLN3 mucolipin 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECOM MDS1 and EVI1 complex locus
MVB12B multivesicular body subunit 12B
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NF1 neurofibromin 1
NNMT nicotinamide N-methyltransferase
NPAS1 neuronal PAS domain protein 1
NTNG1 netrin G1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PALM paralemmin
PCDHGA3 protocadherin gamma subfamily A, 3
PDGFA platelet-derived growth factor alpha polypeptide
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent)
PODNL1 podocan-like 1
POMT2 protein-O-mannosyltransferase 2
PRB1 proline-rich protein BstNI subfamily 1
PROL1 proline rich, lacrimal 1
PRY PTPN13-like, Y-linked
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN7 protein tyrosine phosphatase, non-receptor type 7
RARG retinoic acid receptor, gamma
RASAL2 RAS protein activator like 2
RASSF4 Ras association (RalGDS/AF-6) domain family member 4
RNGTT RNA guanylyltransferase and 5'-phosphatase
RUNX1 runt-related transcription factor 1
SCAND2P SCAN domain containing 2 pseudogene
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SRSF7 serine/arginine-rich splicing factor 7
STAB2 stabilin 2
STS steroid sulfatase (microsomal), isozyme S
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBRG4 transforming growth factor beta regulator 4
THOC5 THO complex 5
TLN2 talin 2
TMEM231 transmembrane protein 231
TRA2A transformer 2 alpha homolog (Drosophila)
TSC22D4 TSC22 domain family, member 4
USH1C Usher syndrome 1C (autosomal recessive, severe)
WNK1 WNK lysine deficient protein kinase 1
ZNF24 zinc finger protein 24
ZNF79 zinc finger protein 79
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ABHD8 abhydrolase domain containing 8
AFF4 AF4/FMR2 family, member 4
AGMAT agmatine ureohydrolase (agmatinase)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANKRD36 ankyrin repeat domain 36
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATAD2B ATPase family, AAA domain containing 2B
ATF7IP2 activating transcription factor 7 interacting protein 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
C11ORF30 chromosome 11 open reading frame 30
C16ORF59 chromosome 16 open reading frame 59
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CCP110 centriolar coiled coil protein 110kDa
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CENPO centromere protein O
CHML choroideremia-like (Rab escort protein 2)
CIR1 corepressor interacting with RBPJ, 1
CPA4 carboxypeptidase A4
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DDN dendrin
DENND4A DENN/MADD domain containing 4A
EDIL3 EGF-like repeats and discoidin I-like domains 3
EXOC6B exocyst complex component 6B
F3 coagulation factor III (thromboplastin, tissue factor)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO40 F-box protein 40
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GJC1 gap junction protein, gamma 1, 45kDa
GPR1 G protein-coupled receptor 1
HAMP hepcidin antimicrobial peptide
HCRP1 hepatocellular carcinoma-related HCRP1
HIST1H1D histone cluster 1, H1d
HIST1H2AK histone cluster 1, H2ak
HPN hepsin
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IL15RA interleukin 15 receptor, alpha
IPO8 importin 8
KATNBL1 katanin p80 subunit B-like 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KRT20 keratin 20, type I
LIMS2 LIM and senescent cell antigen-like domains 2
LMNB1 lamin B1
LMO7 LIM domain 7
LOC100287590 uncharacterized LOC100287590
LRP3 low density lipoprotein receptor-related protein 3
LRP5L low density lipoprotein receptor-related protein 5-like
LTC4S leukotriene C4 synthase
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MTSS1L metastasis suppressor 1-like
MUC3A mucin 3A, cell surface associated
MYLIP myosin regulatory light chain interacting protein
MYOZ3 myozenin 3
NEUROD4 neuronal differentiation 4
NKX3-2 NK3 homeobox 2
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
PDLIM2 PDZ and LIM domain 2 (mystique)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRB3 proline-rich protein BstNI subfamily 3
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
QSER1 glutamine and serine rich 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SIX3 SIX homeobox 3
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SYCP2 synaptonemal complex protein 2
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TESK1 testis-specific kinase 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TUBA3C tubulin, alpha 3c
TUBB2B tubulin, beta 2B class IIb
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VNN1 vanin 1
WDR18 WD repeat domain 18
WDR62 WD repeat domain 62
WFDC2 WAP four-disulfide core domain 2
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB22 zinc finger and BTB domain containing 22
ZNF253 zinc finger protein 253
ZNF358 zinc finger protein 358
ZNF770 zinc finger protein 770
ZXDB zinc finger, X-linked, duplicated B