meclofenoxate-2546 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

194 genes differentially expressed following the meclofenoxate-2546 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AASS aminoadipate-semialdehyde synthase
ADAM22 ADAM metallopeptidase domain 22
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ARHGAP6 Rho GTPase activating protein 6
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
C11ORF80 chromosome 11 open reading frame 80
CAMP cathelicidin antimicrobial peptide
CAPN9 calpain 9
CCDC92 coiled-coil domain containing 92
CCKAR cholecystokinin A receptor
CD247 CD247 molecule
CD52 CD52 molecule
CD6 CD6 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CLEC10A C-type lectin domain family 10, member A
CSHL1 chorionic somatomammotropin hormone-like 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
EN1 engrailed homeobox 1
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR2 fibroblast growth factor receptor 2
FLJ11292
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPR135 G protein-coupled receptor 135
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIST1H2BN histone cluster 1, H2bn
HOXD13 homeobox D13
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFNA21 interferon, alpha 21
IGFBP5 insulin-like growth factor binding protein 5
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IL1RN interleukin 1 receptor antagonist
IL7 interleukin 7
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNK10 potassium channel, two pore domain subfamily K, member 10
KIAA1045 KIAA1045
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4
LAMA4 laminin, alpha 4
LOC1720 dihydrofolate reductase pseudogene
LOC57399 uncharacterized gastric protein ZA52P
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MECOM MDS1 and EVI1 complex locus
MNMIP1 manchette microtubule inner protein 1
MTSS1 metastasis suppressor 1
NRG1 neuregulin 1
PAX2 paired box 2
PDE4DIP phosphodiesterase 4D interacting protein
PKP3 plakophilin 3
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRM2 protamine 2
RAB26 RAB26, member RAS oncogene family
RBM12B-AS1 RBM12B antisense RNA 1
RFPL1 ret finger protein-like 1
RIBC2 RIB43A domain with coiled-coils 2
SAA3P serum amyloid A3 pseudogene
SCN2B sodium channel, voltage gated, type II beta subunit
SIX3 SIX homeobox 3
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC16A4 solute carrier family 16, member 4
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SMR3B submaxillary gland androgen regulated protein 3B
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SOGA1 suppressor of glucose, autophagy associated 1
SPACA1 sperm acrosome associated 1
SPDEF SAM pointed domain containing ETS transcription factor
SPRR2B small proline-rich protein 2B
SPX spexin hormone
SYT5 synaptotagmin V
TBX6 T-box 6
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TESPA1 thymocyte expressed, positive selection associated 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TG thyroglobulin
THBD thrombomodulin
TJP3 tight junction protein 3
TMCC2 transmembrane and coiled-coil domain family 2
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNS1 tensin 1
TP53TG1 TP53 target 1 (non-protein coding)
TSKU tsukushi, small leucine rich proteoglycan
TSR3 TSR3, 20S rRNA accumulation, homolog (S. cerevisiae)
VGLL1 vestigial-like family member 1
XYLB xylulokinase homolog (H. influenzae)
ZDHHC8P1 zinc finger, DHHC-type containing 8 pseudogene 1
ZNF259P1 zinc finger protein 259 pseudogene 1

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AGO3 argonaute RISC catalytic component 3
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ARF5 ADP-ribosylation factor 5
ARHGAP12 Rho GTPase activating protein 12
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BBC3 BCL2 binding component 3
BCORL1 BCL6 corepressor-like 1
BOLA1 bolA family member 1
C10ORF88 chromosome 10 open reading frame 88
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC47 coiled-coil domain containing 47
CDC37L1 cell division cycle 37-like 1
CHEK2 checkpoint kinase 2
CHST10 carbohydrate sulfotransferase 10
CLDN15 claudin 15
COA7 cytochrome c oxidase assembly factor 7 (putative)
CRYZ crystallin, zeta (quinone reductase)
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DENND4A DENN/MADD domain containing 4A
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
E2F8 E2F transcription factor 8
EGLN2 egl-9 family hypoxia-inducible factor 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM179B family with sequence similarity 179, member B
FMNL1 formin-like 1
GATAD2A GATA zinc finger domain containing 2A
GPALPP1 GPALPP motifs containing 1
GPHN gephyrin
GRAMD1B GRAM domain containing 1B
GUSBP3 glucuronidase, beta pseudogene 3
HAUS6 HAUS augmin-like complex, subunit 6
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST2H2BE histone cluster 2, H2be
HRAS Harvey rat sarcoma viral oncogene homolog
IFT88 intraflagellar transport 88
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IMPAD1 inositol monophosphatase domain containing 1
KIF23 kinesin family member 23
LRRC42 leucine rich repeat containing 42
LTB lymphotoxin beta (TNF superfamily, member 3)
LY6E lymphocyte antigen 6 complex, locus E
MAVS mitochondrial antiviral signaling protein
MCRS1 microspherule protein 1
METTL4 methyltransferase like 4
MORC3 MORC family CW-type zinc finger 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDGFC platelet derived growth factor C
PHYH phytanoyl-CoA 2-hydroxylase
PIEZO1 piezo-type mechanosensitive ion channel component 1
PJA1 praja ring finger 1, E3 ubiquitin protein ligase
PKN1 protein kinase N1
PLA2G12A phospholipase A2, group XIIA
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PPAN peter pan homolog (Drosophila)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTCD2 pentatricopeptide repeat domain 2
PXMP4 peroxisomal membrane protein 4, 24kDa
QTRT1 queuine tRNA-ribosyltransferase 1
RASA2 RAS p21 protein activator 2
RBL1 retinoblastoma-like 1
RINT1 RAD50 interactor 1
SCRIB scribbled planar cell polarity protein
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SOAT1 sterol O-acyltransferase 1
SP140L SP140 nuclear body protein-like
SSFA2 sperm specific antigen 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX4 syntaxin 4
SUOX sulfite oxidase
THAP1 THAP domain containing, apoptosis associated protein 1
TMEM115 transmembrane protein 115
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRABD TraB domain containing
TRIM68 tripartite motif containing 68
UEVLD UEV and lactate/malate dehyrogenase domains
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZBTB48 zinc finger and BTB domain containing 48
ZFP30 ZFP30 zinc finger protein
ZNF141 zinc finger protein 141
ZNF227 zinc finger protein 227
ZNF230 zinc finger protein 230
ZNF432 zinc finger protein 432
ZNF468 zinc finger protein 468
ZNF623 zinc finger protein 623