meclofenoxate-4268 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the meclofenoxate-4268 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATN1 atrophin 1
BCAP29 B-cell receptor-associated protein 29
BGN biglycan
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMP cathelicidin antimicrobial peptide
CCDC181 coiled-coil domain containing 181
CCR3 chemokine (C-C motif) receptor 3
CD52 CD52 molecule
CD6 CD6 molecule
CD7 CD7 molecule
CDHR2 cadherin-related family member 2
CHAT choline O-acetyltransferase
CLCN7 chloride channel, voltage-sensitive 7
CNTD2 cyclin N-terminal domain containing 2
COL1A1 collagen, type I, alpha 1
COPE coatomer protein complex, subunit epsilon
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CSHL1 chorionic somatomammotropin hormone-like 1
CST4 cystatin S
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
DOK4 docking protein 4
DSCR4 Down syndrome critical region 4
ELAC2 elaC ribonuclease Z 2
FAM134B family with sequence similarity 134, member B
FGL2 fibrinogen-like 2
FLT3LG fms-related tyrosine kinase 3 ligand
FRY furry homolog (Drosophila)
FSCN3 fascin actin-bundling protein 3, testicular
FZD1 frizzled class receptor 1
GATA4 GATA binding protein 4
GGT1 gamma-glutamyltransferase 1
GGTLC1 gamma-glutamyltransferase light chain 1
GPR17 G protein-coupled receptor 17
GPR27 G protein-coupled receptor 27
GRM8 glutamate receptor, metabotropic 8
GZMK granzyme K (granzyme 3; tryptase II)
HOXB3 homeobox B3
IBSP integrin-binding sialoprotein
IGHA1 immunoglobulin heavy constant alpha 1
IGL immunoglobulin lambda locus
IL2RA interleukin 2 receptor, alpha
IL33R interleukin 33 receptor
INE1 inactivation escape 1 (non-protein coding)
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KIF25-AS1 KIF25 antisense RNA 1
KLHL35 kelch-like family member 35
KRT31 keratin 31, type I
KYNU kynureninase
LAMB4 laminin, beta 4
LDB3 LIM domain binding 3
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LOC392555 melanoma antigen family C2 pseudogene
LOXL3 lysyl oxidase-like 3
MAP7D3 MAP7 domain containing 3
MMP11 matrix metallopeptidase 11
MNMIP1 manchette microtubule inner protein 1
MSMB microseminoprotein, beta-
NAG18 NAG18 mRNA
NUDT7 nudix (nucleoside diphosphate linked moiety X)-type motif 7
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OSBP2 oxysterol binding protein 2
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PBX1 pre-B-cell leukemia homeobox 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLCH2 phospholipase C, eta 2
PLIN2 perilipin 2
PRAF2 PRA1 domain family, member 2
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGS12 regulator of G-protein signaling 12
RIF1 replication timing regulatory factor 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCARF1 scavenger receptor class F, member 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SELL selectin L
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SFTPB surfactant protein B
SH3BP1 SH3-domain binding protein 1
SIX3 SIX homeobox 3
SLAMF7 SLAM family member 7
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
TBC1D30 TBC1 domain family, member 30
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
TMEM259 transmembrane protein 259
TOP3A topoisomerase (DNA) III alpha
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
TRIM3 tripartite motif containing 3
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae)
TSC2 tuberous sclerosis 2
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15
UTS2 urotensin 2
ZFHX3 zinc finger homeobox 3
ZNF750 zinc finger protein 750

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADAM15 ADAM metallopeptidase domain 15
ANKRD36 ankyrin repeat domain 36
APOL6 apolipoprotein L, 6
APOLD1 apolipoprotein L domain containing 1
ASB13 ankyrin repeat and SOCS box containing 13
C16ORF59 chromosome 16 open reading frame 59
C1R complement component 1, r subcomponent
CEP295 centrosomal protein 295kDa
CEPT1 choline/ethanolamine phosphotransferase 1
CIR1 corepressor interacting with RBPJ, 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DCAF13 DDB1 and CUL4 associated factor 13
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEPDC1 DEP domain containing 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
FAM204A family with sequence similarity 204, member A
FBRS fibrosin
FER fer (fps/fes related) tyrosine kinase
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GJC1 gap junction protein, gamma 1, 45kDa
GPALPP1 GPALPP motifs containing 1
GPATCH2L G patch domain containing 2-like
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1D histone cluster 1, H1d
HIST1H1E histone cluster 1, H1e
HIST1H4C histone cluster 1, H4c
IFI6 interferon, alpha-inducible protein 6
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFT22 intraflagellar transport 22
IKZF5 IKAROS family zinc finger 5 (Pegasus)
KIAA0319L KIAA0319-like
KIRREL kin of IRRE like (Drosophila)
LHX6 LIM homeobox 6
LINC00597 long intergenic non-protein coding RNA 597
LMNB1 lamin B1
MAGOHB mago-nashi homolog B (Drosophila)
MAP3K2 mitogen-activated protein kinase kinase kinase 2
METTL16 methyltransferase like 16
METTL8 methyltransferase like 8
MIS12 MIS12 kinetochore complex component
MIS18BP1 MIS18 binding protein 1
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MTMR6 myotubularin related protein 6
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NMB neuromedin B
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PERP PERP, TP53 apoptosis effector
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PID1 phosphotyrosine interaction domain containing 1
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PMCH pro-melanin-concentrating hormone
POLR2J2 polymerase (RNA) II (DNA directed) polypeptide J2
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PSENEN presenilin enhancer gamma secretase subunit
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RBBP5 retinoblastoma binding protein 5
RFX7 regulatory factor X, 7
RIT1 Ras-like without CAAX 1
RPS14P3 ribosomal protein S14 pseudogene 3
SARS2 seryl-tRNA synthetase 2, mitochondrial
SDC3 syndecan 3
SKI SKI proto-oncogene
SMAD5 SMAD family member 5
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPIN1 spindlin 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD3 StAR-related lipid transfer (START) domain containing 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TH tyrosine hydroxylase
TIPRL TOR signaling pathway regulator
TM6SF1 transmembrane 6 superfamily member 1
TMEM209 transmembrane protein 209
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRABD TraB domain containing
TRPS1 trichorhinophalangeal syndrome I
TTF2 transcription termination factor, RNA polymerase II
VASH2 vasohibin 2
XYLT2 xylosyltransferase II
ZBTB10 zinc finger and BTB domain containing 10
ZC3H4 zinc finger CCCH-type containing 4
ZNF273 zinc finger protein 273
ZNF385D zinc finger protein 385D
ZNF468 zinc finger protein 468
ZNF551 zinc finger protein 551