meclozine-3285 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the meclozine-3285 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
AMOTL2 angiomotin like 2
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARTN artemin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
C14ORF93 chromosome 14 open reading frame 93
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CCNG2 cyclin G2
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD70 CD70 molecule
CDC25C cell division cycle 25C
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN7 chloride channel, voltage-sensitive 7
COL3A1 collagen, type III, alpha 1
CORO7 coronin 7
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPDC5 DEP domain containing 5
DNAH17 dynein, axonemal, heavy chain 17
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP10 dual specificity phosphatase 10
DUSP9 dual specificity phosphatase 9
EHD1 EH-domain containing 1
F13A1 coagulation factor XIII, A1 polypeptide
FANCA Fanconi anemia, complementation group A
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAP43 growth associated protein 43
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GPR85 G protein-coupled receptor 85
GTPBP2 GTP binding protein 2
HOXA10 homeobox A10
HOXB2 homeobox B2
HPGDS hematopoietic prostaglandin D synthase
ICAM1 intercellular adhesion molecule 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
INHBE inhibin, beta E
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA1107 KIAA1107
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF12 Kruppel-like factor 12
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LMTK2 lemur tyrosine kinase 2
LTB lymphotoxin beta (TNF superfamily, member 3)
MAP1B microtubule-associated protein 1B
MAP2K5 mitogen-activated protein kinase kinase 5
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MDM4 MDM4, p53 regulator
MR1 major histocompatibility complex, class I-related
NF2 neurofibromin 2 (merlin)
NUPR1 nuclear protein, transcriptional regulator, 1
OVGP1 oviductal glycoprotein 1, 120kDa
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PIGR polymeric immunoglobulin receptor
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E
RANBP10 RAN binding protein 10
RASA3 RAS p21 protein activator 3
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SFI1 Sfi1 homolog, spindle assembly associated (yeast)
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOS2 son of sevenless homolog 2 (Drosophila)
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
SPTBN2 spectrin, beta, non-erythrocytic 2
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STX7 syntaxin 7
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
TBL2 transducin (beta)-like 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
THRAP3 thyroid hormone receptor associated protein 3
TM4SF20 transmembrane 4 L six family member 20
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
TSC22D4 TSC22 domain family, member 4
TSHR thyroid stimulating hormone receptor
TTC38 tetratricopeptide repeat domain 38
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZER1 zyg-11 related, cell cycle regulator
ZNF609 zinc finger protein 609
ZNF76 zinc finger protein 76
ZNF768 zinc finger protein 768
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACSL4 acyl-CoA synthetase long-chain family member 4
ACTL8 actin-like 8
ACVR2B activin A receptor, type IIB
ADAM15 ADAM metallopeptidase domain 15
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
BPGM 2,3-bisphosphoglycerate mutase
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C2ORF27A chromosome 2 open reading frame 27A
C5AR2 complement component 5a receptor 2
CAMK1 calcium/calmodulin-dependent protein kinase I
CAPN5 calpain 5
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CENPQ centromere protein Q
CLIC3 chloride intracellular channel 3
CNGB3 cyclic nucleotide gated channel beta 3
CTRL chymotrypsin-like
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DCAF16 DDB1 and CUL4 associated factor 16
DIXDC1 DIX domain containing 1
EFNA3 ephrin-A3
ELOVL4 ELOVL fatty acid elongase 4
ERCC4 excision repair cross-complementation group 4
ERN2 endoplasmic reticulum to nucleus signaling 2
FA2H fatty acid 2-hydroxylase
FAM188A family with sequence similarity 188, member A
FAN1 FANCD2/FANCI-associated nuclease 1
FBXO31 F-box protein 31
FBXW12 F-box and WD repeat domain containing 12
FSTL3 follistatin-like 3 (secreted glycoprotein)
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GINS4 GINS complex subunit 4 (Sld5 homolog)
GMPR guanosine monophosphate reductase
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
HIST1H4F histone cluster 1, H4f
HOXC10 homeobox C10
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IQCG IQ motif containing G
IRAK4 interleukin-1 receptor-associated kinase 4
JMJD4 jumonji domain containing 4
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KCTD7 potassium channel tetramerization domain containing 7
KREMEN2 kringle containing transmembrane protein 2
LTC4S leukotriene C4 synthase
LY6D lymphocyte antigen 6 complex, locus D
MBTPS2 membrane-bound transcription factor peptidase, site 2
MED18 mediator complex subunit 18
METTL2B methyltransferase like 2B
MFSD11 major facilitator superfamily domain containing 11
NIPAL2 NIPA-like domain containing 2
NPFFR1 neuropeptide FF receptor 1
NPTX1 neuronal pentraxin I
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PCDHB13 protocadherin beta 13
PDIA3 protein disulfide isomerase family A, member 3
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PGBD5 piggyBac transposable element derived 5
PHEX phosphate regulating endopeptidase homolog, X-linked
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLXNA3 plexin A3
PROCR protein C receptor, endothelial
PRR14L proline rich 14-like
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PTK6 protein tyrosine kinase 6
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
SCAI suppressor of cancer cell invasion
SECTM1 secreted and transmembrane 1
SETD1A SET domain containing 1A
SLC12A8 solute carrier family 12, member 8
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SPATA2L spermatogenesis associated 2-like
STK4 serine/threonine kinase 4
STRA6 stimulated by retinoic acid 6
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TEP1 telomerase-associated protein 1
TFF2 trefoil factor 2
TH tyrosine hydroxylase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TMEM209 transmembrane protein 209
TRPV6 transient receptor potential cation channel, subfamily V, member 6
ULBP2 UL16 binding protein 2
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR76 WD repeat domain 76
WFDC2 WAP four-disulfide core domain 2
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF137P zinc finger protein 137, pseudogene
ZNF204P zinc finger protein 204, pseudogene
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721