meclozine-4646 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the meclozine-4646 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADAM11 ADAM metallopeptidase domain 11
ADAMDEC1 ADAM-like, decysin 1
AK5 adenylate kinase 5
ARTN artemin
B9D2 B9 protein domain 2
C11ORF1 chromosome 11 open reading frame 1
C8A complement component 8, alpha polypeptide
CARD10 caspase recruitment domain family, member 10
CCDC28B coiled-coil domain containing 28B
CD58 CD58 molecule
CD6 CD6 molecule
CDC25C cell division cycle 25C
CEP295 centrosomal protein 295kDa
CNGB3 cyclic nucleotide gated channel beta 3
COL10A1 collagen, type X, alpha 1
COL9A3 collagen, type IX, alpha 3
CSPG4 chondroitin sulfate proteoglycan 4
E2F4 E2F transcription factor 4, p107/p130-binding
EPB41L5 erythrocyte membrane protein band 4.1 like 5
FAM163A family with sequence similarity 163, member A
FLJ11292
FLRT2 fibronectin leucine rich transmembrane protein 2
GAL galanin/GMAP prepropeptide
GJA8 gap junction protein, alpha 8, 50kDa
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
H2AFX H2A histone family, member X
HGD homogentisate 1,2-dioxygenase
HIST1H2AL histone cluster 1, H2al
HOXB1 homeobox B1
HSPB6 heat shock protein, alpha-crystallin-related, B6
HYAL4 hyaluronoglucosaminidase 4
IDS iduronate 2-sulfatase
IGHM immunoglobulin heavy constant mu
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIF21B kinesin family member 21B
KLRC4 killer cell lectin-like receptor subfamily C, member 4
LARGE like-glycosyltransferase
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LOC79999 uncharacterized LOC79999
LYRM9 LYR motif containing 9
MNMIP1 manchette microtubule inner protein 1
MRAS muscle RAS oncogene homolog
MYL10 myosin, light chain 10, regulatory
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
NCAM1 neural cell adhesion molecule 1
NEFM neurofilament, medium polypeptide
NF1 neurofibromin 1
NFIB nuclear factor I/B
NIPAL3 NIPA-like domain containing 3
NMUR1 neuromedin U receptor 1
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NPVF neuropeptide VF precursor
NR5A2 nuclear receptor subfamily 5, group A, member 2
NRP2 neuropilin 2
NRXN3 neurexin 3
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OR10H2 olfactory receptor, family 10, subfamily H, member 2
OR2H2 olfactory receptor, family 2, subfamily H, member 2
ORM1 orosomucoid 1
OSGIN2 oxidative stress induced growth inhibitor family member 2
PARP8 poly (ADP-ribose) polymerase family, member 8
PDCD2 programmed cell death 2
PDE12 phosphodiesterase 12
PEX3 peroxisomal biogenesis factor 3
PLXNB3 plexin B3
PRDM12 PR domain containing 12
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RPL10L ribosomal protein L10-like
RPL23AP32 ribosomal protein L23a pseudogene 32
SARM1 sterile alpha and TIR motif containing 1
SH3BP2 SH3-domain binding protein 2
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC22A14 solute carrier family 22, member 14
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC44A1 solute carrier family 44 (choline transporter), member 1
SNX1 sorting nexin 1
SOGA1 suppressor of glucose, autophagy associated 1
SPO11 SPO11 meiotic protein covalently bound to DSB
STX7 syntaxin 7
SUSD5 sushi domain containing 5
SYCP2 synaptonemal complex protein 2
TAL1 T-cell acute lymphocytic leukemia 1
TDRD12 tudor domain containing 12
TGFB1 transforming growth factor, beta 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM140 transmembrane protein 140
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53TG5 TP53 target 5
TTC22 tetratricopeptide repeat domain 22
UNC13A unc-13 homolog A (C. elegans)
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
WNT2B wingless-type MMTV integration site family, member 2B
ZC3H7B zinc finger CCCH-type containing 7B
ZNF81 zinc finger protein 81

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADAM15 ADAM metallopeptidase domain 15
ADAM23 ADAM metallopeptidase domain 23
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRG6 adhesion G protein-coupled receptor G6
AFAP1 actin filament associated protein 1
ANOS1 anosmin 1
APOLD1 apolipoprotein L domain containing 1
C17ORF80 chromosome 17 open reading frame 80
C9ORF40 chromosome 9 open reading frame 40
CCNO cyclin O
CDH3 cadherin 3, type 1, P-cadherin (placental)
CEP85 centrosomal protein 85kDa
CHD8 chromodomain helicase DNA binding protein 8
CHM choroideremia (Rab escort protein 1)
CLDN15 claudin 15
CLDND1 claudin domain containing 1
CNTLN centlein, centrosomal protein
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DBF4B DBF4 zinc finger B
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
EFNA3 ephrin-A3
EML4 echinoderm microtubule associated protein like 4
EVPL envoplakin
EXOC5 exocyst complex component 5
EYA4 EYA transcriptional coactivator and phosphatase 4
F3 coagulation factor III (thromboplastin, tissue factor)
FER fer (fps/fes related) tyrosine kinase
FGD6 FYVE, RhoGEF and PH domain containing 6
FKBP10 FK506 binding protein 10, 65 kDa
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GDAP1 ganglioside induced differentiation associated protein 1
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPR176 G protein-coupled receptor 176
GTPBP2 GTP binding protein 2
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA1 homeobox A1
HYAL3 hyaluronoglucosaminidase 3
IL32 interleukin 32
KLF3 Kruppel-like factor 3 (basic)
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LIG4 ligase IV, DNA, ATP-dependent
LOC100127972 uncharacterized LOC100127972
LRP5L low density lipoprotein receptor-related protein 5-like
MBTPS1 membrane-bound transcription factor peptidase, site 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NME5 NME/NM23 family member 5
NT5E 5'-nucleotidase, ecto (CD73)
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
P3H2 prolyl 3-hydroxylase 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PCOLCE procollagen C-endopeptidase enhancer
PDGFRL platelet-derived growth factor receptor-like
PELP1 proline, glutamate and leucine rich protein 1
PIEZO1 piezo-type mechanosensitive ion channel component 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PRSS8 protease, serine, 8
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB35 RAB35, member RAS oncogene family
ROM1 retinal outer segment membrane protein 1
RPH3AL rabphilin 3A-like (without C2 domains)
SCYL2 SCY1-like 2 (S. cerevisiae)
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SETD8 SET domain containing (lysine methyltransferase) 8
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SRD5A3 steroid 5 alpha-reductase 3
STARD3 StAR-related lipid transfer (START) domain containing 3
THBS3 thrombospondin 3
THOP1 thimet oligopeptidase 1
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOR4A torsin family 4, member A
TRIM25 tripartite motif containing 25
TSPAN1 tetraspanin 1
TWISTNB TWIST neighbor
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR25 WD repeat domain 25
WDR33 WD repeat domain 33
WDR91 WD repeat domain 91
XAB2 XPA binding protein 2
ZC3H12A zinc finger CCCH-type containing 12A
ZNF141 zinc finger protein 141
ZNF227 zinc finger protein 227
ZNF428 zinc finger protein 428
ZNF529 zinc finger protein 529
ZNF675 zinc finger protein 675
ZNF76 zinc finger protein 76