meclozine-5607 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the meclozine-5607 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A2M alpha-2-macroglobulin
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit
ARMC4 armadillo repeat containing 4
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATP10A ATPase, class V, type 10A
AVPR1B arginine vasopressin receptor 1B
BTG2 BTG family, member 2
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALCR calcitonin receptor
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD300C CD300c molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CFHR4 complement factor H-related 4
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN4 chloride channel, voltage-sensitive 4
CTIF CBP80/20-dependent translation initiation factor
CTSS cathepsin S
DCTN1 dynactin 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMPK dystrophia myotonica-protein kinase
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FGF1 fibroblast growth factor 1 (acidic)
FST follistatin
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GFER growth factor, augmenter of liver regeneration
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPRC5D G protein-coupled receptor, class C, group 5, member D
GRK5 G protein-coupled receptor kinase 5
GRM4 glutamate receptor, metabotropic 4
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA10 homeobox A10
HOXA11 homeobox A11
IFT27 intraflagellar transport 27
ING4 inhibitor of growth family, member 4
INHBE inhibin, beta E
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITM2C integral membrane protein 2C
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF13A kinesin family member 13A
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL29 kelch-like family member 29
KLK13 kallikrein-related peptidase 13
KRT83 keratin 83, type II
LAMA4 laminin, alpha 4
LARP6 La ribonucleoprotein domain family, member 6
LDHB lactate dehydrogenase B
LHX1 LIM homeobox 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAGEA3 melanoma antigen family A3
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MBD2 methyl-CpG binding domain protein 2
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MYBPC3 myosin binding protein C, cardiac
NDRG2 NDRG family member 2
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NOVA2 neuro-oncological ventral antigen 2
NUMA1 nuclear mitotic apparatus protein 1
NUPR1 nuclear protein, transcriptional regulator, 1
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHLDB1 pleckstrin homology-like domain, family B, member 1
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLD1 phospholipase D1, phosphatidylcholine-specific
POPDC3 popeye domain containing 3
PTGDS prostaglandin D2 synthase 21kDa (brain)
PURG purine-rich element binding protein G
RAB6B RAB6B, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RND1 Rho family GTPase 1
RUSC2 RUN and SH3 domain containing 2
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SOX2 SRY (sex determining region Y)-box 2
SSX1 synovial sarcoma, X breakpoint 1
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBXA2R thromboxane A2 receptor
TGFB2 transforming growth factor, beta 2
TM4SF1 transmembrane 4 L six family member 1
TMPRSS11D transmembrane protease, serine 11D
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TTLL7 tubulin tyrosine ligase-like family member 7
TUBB2B tubulin, beta 2B class IIb
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VIM vimentin
VIPR1 vasoactive intestinal peptide receptor 1
WSCD1 WSC domain containing 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADTRP androgen-dependent TFPI-regulating protein
AKIP1 A kinase (PRKA) interacting protein 1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARTN artemin
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
C14ORF93 chromosome 14 open reading frame 93
C17ORF80 chromosome 17 open reading frame 80
CES3 carboxylesterase 3
CHKB choline kinase beta
CHM choroideremia (Rab escort protein 1)
CHRM3 cholinergic receptor, muscarinic 3
CRLF1 cytokine receptor-like factor 1
CUEDC1 CUE domain containing 1
CXCL12 chemokine (C-X-C motif) ligand 12
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DEAF1 DEAF1 transcription factor
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DVL1 dishevelled segment polarity protein 1
EDAR ectodysplasin A receptor
EGR3 early growth response 3
ELOVL2 ELOVL fatty acid elongase 2
EPN1 epsin 1
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM155A family with sequence similarity 155, member A
FAM198B family with sequence similarity 198, member B
FKBP5 FK506 binding protein 5
GDAP1 ganglioside induced differentiation associated protein 1
GFI1 growth factor independent 1 transcription repressor
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJA1 gap junction protein, alpha 1, 43kDa
GJA9 gap junction protein, alpha 9, 59kDa
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HAMP hepcidin antimicrobial peptide
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
IGFBP6 insulin-like growth factor binding protein 6
IL4R interleukin 4 receptor
INO80D INO80 complex subunit D
IPO8 importin 8
KLHL36 kelch-like family member 36
KLK5 kallikrein-related peptidase 5
KREMEN2 kringle containing transmembrane protein 2
LOXL3 lysyl oxidase-like 3
MUM1 melanoma associated antigen (mutated) 1
MVP major vault protein
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NPY1R neuropeptide Y receptor Y1
NPY5R neuropeptide Y receptor Y5
NR1H3 nuclear receptor subfamily 1, group H, member 3
OR1G1 olfactory receptor, family 1, subfamily G, member 1
OVGP1 oviductal glycoprotein 1, 120kDa
PCDHB13 protocadherin beta 13
PDZK1 PDZ domain containing 1
PGP phosphoglycolate phosphatase
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLEKHO2 pleckstrin homology domain containing, family O member 2
PODNL1 podocan-like 1
PODXL podocalyxin-like
PRPH peripherin
PRSS53 protease, serine, 53
PYCRL pyrroline-5-carboxylate reductase-like
R3HCC1L R3H domain and coiled-coil containing 1-like
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RCAN3 RCAN family member 3
RHOBTB2 Rho-related BTB domain containing 2
RNF39 ring finger protein 39
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SENP7 SUMO1/sentrin specific peptidase 7
SGK1 serum/glucocorticoid regulated kinase 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SP1 Sp1 transcription factor
SPINK4 serine peptidase inhibitor, Kazal type 4
SSTR4 somatostatin receptor 4
STRN striatin, calmodulin binding protein
SULT1B1 sulfotransferase family, cytosolic, 1B, member 1
SULT4A1 sulfotransferase family 4A, member 1
SYCP2 synaptonemal complex protein 2
TGFBR1 transforming growth factor, beta receptor 1
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM45A transmembrane protein 45A
TMPRSS3 transmembrane protease, serine 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPST2 tyrosylprotein sulfotransferase 2
TUBA3C tubulin, alpha 3c
UNC93B1 unc-93 homolog B1 (C. elegans)
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
ZBTB44 zinc finger and BTB domain containing 44
ZNF141 zinc finger protein 141
ZNF204P zinc finger protein 204, pseudogene
ZNF254 zinc finger protein 254
ZNF324 zinc finger protein 324
ZNF480 zinc finger protein 480