mecp2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description methyl CpG binding protein 2|DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. [provided by RefSeq, Jul 2009] (NCBI Entrez Gene Database, 4204)
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Genes

50 genes co-occuring with the biological term mecp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATRX alpha thalassemia/mental retardation syndrome X-linked
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BDNF brain-derived neurotrophic factor
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
CDKL5 cyclin-dependent kinase-like 5
CHUK conserved helix-loop-helix ubiquitous kinase
DLX5 distal-less homeobox 5
DLX6 distal-less homeobox 6
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTNBP1 dystrobrevin binding protein 1
EGR2 early growth response 2
ESR1 estrogen receptor 1
FXYD1 FXYD domain containing ion transport regulator 1
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
HDAC1 histone deacetylase 1
HIPK2 homeodomain interacting protein kinase 2
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMGN1 high mobility group nucleosome binding domain 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IRAK1 interleukin-1 receptor-associated kinase 1
LBR lamin B receptor
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MBD1 methyl-CpG binding domain protein 1
MBD2 methyl-CpG binding domain protein 2
MECP2 methyl CpG binding protein 2
MEF2C myocyte enhancer factor 2C
MGMT O-6-methylguanine-DNA methyltransferase
MIR432 microRNA 432
MIR483 microRNA 483
MIR511 microRNA 511
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NES nestin
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PGR progesterone receptor
RCOR1 REST corepressor 1
RNF4 ring finger protein 4
SIN3A SIN3 transcription regulator family member A
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SPI1 Spi-1 proto-oncogene
TP53 tumor protein p53
TUBA1B tubulin, alpha 1b
VEGFA vascular endothelial growth factor A
YY1 YY1 transcription factor