mediators Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Similar Terms
Downloads & Tools

Genes

433 genes co-occuring with the biological term mediators in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACE angiotensin I converting enzyme
ACLY ATP citrate lyase
ACVRL1 activin A receptor type II-like 1
ADA adenosine deaminase
ADAM15 ADAM metallopeptidase domain 15
ADAM17 ADAM metallopeptidase domain 17
ADGRE2 adhesion G protein-coupled receptor E2
ADIPOQ adiponectin, C1Q and collagen domain containing
ADRA2A adrenoceptor alpha 2A
ADRBK1 adrenergic, beta, receptor kinase 1
AHSG alpha-2-HS-glycoprotein
AIMP1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
AIRE autoimmune regulator
AKAP5 A kinase (PRKA) anchor protein 5
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ALOX15 arachidonate 15-lipoxygenase
ALOX5 arachidonate 5-lipoxygenase
ANGPT2 angiopoietin 2
ANXA1 annexin A1
ANXA2 annexin A2
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APP amyloid beta (A4) precursor protein
AR androgen receptor
ARRB2 arrestin, beta 2
ASPH aspartate beta-hydroxylase
ATF1 activating transcription factor 1
ATF4 activating transcription factor 4
ATF6 activating transcription factor 6
ATM ATM serine/threonine kinase
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AURKA aurora kinase A
AVP arginine vasopressin
AZU1 azurocidin 1
BAD BCL2-associated agonist of cell death
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL10 B-cell CLL/lymphoma 10
BOK BCL2-related ovarian killer
C5 complement component 5
C5AR1 complement component 5a receptor 1
CARD10 caspase recruitment domain family, member 10
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCL26 chemokine (C-C motif) ligand 26
CCL27 chemokine (C-C motif) ligand 27
CCL5 chemokine (C-C motif) ligand 5
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD14 CD14 molecule
CD163 CD163 molecule
CD1D CD1d molecule
CD28 CD28 molecule
CD300A CD300a molecule
CD300LB CD300 molecule-like family member b
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42 cell division cycle 42
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK4 cyclin-dependent kinase 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK6 cyclin-dependent kinase 6
CDK8 cyclin-dependent kinase 8
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHD1 chromodomain helicase DNA binding protein 1
CHIA chitinase, acidic
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN4 claudin 4
CLEC1B C-type lectin domain family 1, member B
CMA1 chymase 1, mast cell
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
CREB1 cAMP responsive element binding protein 1
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CSF1 colony stimulating factor 1 (macrophage)
CSF1R colony stimulating factor 1 receptor
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CTGF connective tissue growth factor
CTNND1 catenin (cadherin-associated protein), delta 1
CTSB cathepsin B
CTSG cathepsin G
CTSH cathepsin H
CTSL cathepsin L
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL16 chemokine (C-X-C motif) ligand 16
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR3 chemokine (C-X-C motif) receptor 3
DEDD death effector domain containing
DEDD2 death effector domain containing 2
DEFB4A defensin, beta 4A
ECE1 endothelin converting enzyme 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ENG endoglin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EP300 E1A binding protein p300
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAS Fas cell surface death receptor
FASN fatty acid synthase
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR3 fibroblast growth factor receptor 3
FHL5 four and a half LIM domains 5
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLNA filamin A, alpha
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXO3 forkhead box O3
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FPR3 formyl peptide receptor 3
FTO fat mass and obesity associated
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45G growth arrest and DNA-damage-inducible, gamma
GBA glucosidase, beta, acid
GH1 growth hormone 1
GLRX glutaredoxin (thioltransferase)
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GP6 glycoprotein VI (platelet)
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
HAMP hepcidin antimicrobial peptide
HAS2 hyaluronan synthase 2
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
HOXB9 homeobox B9
HRH4 histamine receptor H4
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFNG interferon, gamma
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL10 interleukin 10
IL12A interleukin 12A
IL13 interleukin 13
IL18 interleukin 18
IL19 interleukin 19
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL20 interleukin 20
IL24 interleukin 24
IL31 interleukin 31
IL33 interleukin 33
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL6 interleukin 6
INHBA inhibin, beta A
IRAK1 interleukin-1 receptor-associated kinase 1
IRF5 interferon regulatory factor 5
IRF7 interferon regulatory factor 7
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITGB5 integrin, beta 5
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JUN jun proto-oncogene
JUND jun D proto-oncogene
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNK2 potassium channel, two pore domain subfamily K, member 2
KHK ketohexokinase (fructokinase)
LAMA5 laminin, alpha 5
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LMO2 LIM domain only 2 (rhombotin-like 1)
LTA lymphotoxin alpha
LTC4S leukotriene C4 synthase
LTF lactotransferrin
LYZ lysozyme
MALT1 MALT1 paracaspase
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MAPT microtubule-associated protein tau
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MECOM MDS1 and EVI1 complex locus
MED25 mediator complex subunit 25
MIEF1 mitochondrial elongation factor 1
MIEF2 mitochondrial elongation factor 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR125B1 microRNA 125b-1
MIR143 microRNA 143
MIR145 microRNA 145
MIR146A microRNA 146a
MIR18A microRNA 18a
MIR200B microRNA 200b
MIR200C microRNA 200c
MIR219A2 microRNA 219a-2
MIR26A1 microRNA 26a-1
MIR26B microRNA 26b
MIR31 microRNA 31
MKL1 megakaryoblastic leukemia (translocation) 1
MKL2 MKL/myocardin-like 2
MMP1 matrix metallopeptidase 1
MMP13 matrix metallopeptidase 13
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MSX2 msh homeobox 2
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC1 mucin 1, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYD88 myeloid differentiation primary response 88
NF1 neurofibromin 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NPPC natriuretic peptide C
NPY neuropeptide Y
NPY1R neuropeptide Y receptor Y1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NTN1 netrin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OXT oxytocin/neurophysin I prepropeptide
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAOX polyamine oxidase (exo-N4-amino)
PBX1 pre-B-cell leukemia homeobox 1
PCSK9 proprotein convertase subtilisin/kexin type 9
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PGF placental growth factor
PHB prohibitin
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLA2G10 phospholipase A2, group X
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POMC proopiomelanocortin
PPAPDC2 phosphatidic acid phosphatase type 2 domain containing 2
PPARD peroxisome proliferator-activated receptor delta
PPARG peroxisome proliferator-activated receptor gamma
PRDX3 peroxiredoxin 3
PRLR prolactin receptor
PROCR protein C receptor, endothelial
PROX1 prospero homeobox 1
PTAFR platelet-activating factor receptor
PTEN phosphatase and tensin homolog
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2B protein tyrosine kinase 2 beta
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRC protein tyrosine phosphatase, receptor type, C
RAB7B RAB7B, member RAS oncogene family
RAB9A RAB9A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RARA retinoic acid receptor, alpha
RARB retinoic acid receptor, beta
RBP4 retinol binding protein 4, plasma
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RETN resistin
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S1PR1 sphingosine-1-phosphate receptor 1
S1PR2 sphingosine-1-phosphate receptor 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SELE selectin E
SENP1 SUMO1/sentrin specific peptidase 1
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SH3RF1 SH3 domain containing ring finger 1
SIAH2 siah E3 ubiquitin protein ligase 2
SIGLEC11 sialic acid binding Ig-like lectin 11
SIRT1 sirtuin 1
SKI SKI proto-oncogene
SKIL SKI-like proto-oncogene
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLPI secretory leukocyte peptidase inhibitor
SMAD3 SMAD family member 3
SMC3 structural maintenance of chromosomes 3
SMO smoothened, frizzled class receptor
SMOX spermine oxidase
SNAI1 snail family zinc finger 1
SNAI2 snail family zinc finger 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
STAB2 stabilin 2
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TACR1 tachykinin receptor 1
TACR2 tachykinin receptor 2
TACR3 tachykinin receptor 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TCP1 t-complex 1
TFAM transcription factor A, mitochondrial
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TICAM1 toll-like receptor adaptor molecule 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNC tenascin C
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TP53 tumor protein p53
TP63 tumor protein p63
TP73 tumor protein p73
TPSAB1 tryptase alpha/beta 1
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIB1 tribbles pseudokinase 1
TRIB2 tribbles pseudokinase 2
TRIB3 tribbles pseudokinase 3
TRPA1 transient receptor potential cation channel, subfamily A, member 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSHR thyroid stimulating hormone receptor
TSLP thymic stromal lymphopoietin
TSPO2 translocator protein 2
TWIST1 twist family bHLH transcription factor 1
UCN urocortin
UCN2 urocortin 2
UCN3 urocortin 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VCAM1 vascular cell adhesion molecule 1
VCP valosin containing protein
VEGFA vascular endothelial growth factor A
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
XBP1 X-box binding protein 1
YAP1 Yes-associated protein 1
YY1AP1 YY1 associated protein 1
ZHX1 zinc fingers and homeoboxes 1
ZHX2 zinc fingers and homeoboxes 2
ZHX3 zinc fingers and homeoboxes 3