medulloblastoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)|A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, desmoplastic medulloblastoma, large cell medulloblastoma, and medulloblastoma with extensive nodularity and advanced neuronal differentiation. (from NCI Thesuarus) (Experimental Factor Ontology, EFO_0002939)
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Genes

540 genes co-occuring with the disease medulloblastoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SHH sonic hedgehog 2.51898
PTCH1 patched 1 2.34065
PPP1R12A protein phosphatase 1, regulatory subunit 12A 2.12715
GLI1 GLI family zinc finger 1 2.03155
SMO smoothened, frizzled class receptor 2.02205
CD99 CD99 molecule 1.9727
EWSR1 EWS RNA-binding protein 1 1.97082
ENO2 enolase 2 (gamma, neuronal) 1.95253
SYP synaptophysin 1.89963
SUFU suppressor of fused homolog (Drosophila) 1.81058
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.68408
FLI1 Fli-1 proto-oncogene, ETS transcription factor 1.63321
TP53 tumor protein p53 1.61083
KCTD11 potassium channel tetramerization domain containing 11 1.58939
OTX2 orthodenticle homeobox 2 1.56311
GFAP glial fibrillary acidic protein 1.51281
GLI2 GLI family zinc finger 2 1.50096
NES nestin 1.47813
ATOH1 atonal homolog 1 (Drosophila) 1.47154
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 1.35594
PTCH2 patched 2 1.31537
PROM1 prominin 1 1.30794
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.27955
ZIC1 Zic family member 1 1.1798
HIC1 hypermethylated in cancer 1 1.1605
NOTCH1 notch 1 1.1051
FANCL Fanconi anemia, complementation group L 1.09587
INSM1 insulinoma-associated 1 1.07866
B3GAT1 beta-1,3-glucuronyltransferase 1 1.07404
MSI1 musashi RNA-binding protein 1 1.07236
NOTCH2 notch 2 1.04125
NOTCH2NL notch 2 N-terminal like 1.0383
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.02988
MGMT O-6-methylguanine-DNA methyltransferase 1.02566
FSTL5 follistatin-like 5 0.985585
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.967921
AXIN1 axin 1 0.955361
SAG S-antigen; retina and pineal gland (arrestin) 0.942858
BMI1 BMI1 proto-oncogene, polycomb ring finger 0.934141
CENPV centromere protein V 0.927105
MAP2 microtubule-associated protein 2 0.922974
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 0.921323
CCND1 cyclin D1 0.908553
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.908553
NCAM1 neural cell adhesion molecule 1 0.906909
CASP8 caspase 8, apoptosis-related cysteine peptidase 0.902389
NGF nerve growth factor (beta polypeptide) 0.901567
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.893769
ERBB2 erb-b2 receptor tyrosine kinase 2 0.892538
NGFR nerve growth factor receptor 0.888029
PTPRC protein tyrosine phosphatase, receptor type, C 0.887208
EGFR epidermal growth factor receptor 0.882701
HPDL 4-hydroxyphenylpyruvate dioxygenase-like 0.873281
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 0.873281
ARHGAP36 Rho GTPase activating protein 36 0.873281
BARHL1 BarH-like homeobox 1 0.872053
AKT1 v-akt murine thymoma viral oncogene homolog 1 0.867549
RPH3AL rabphilin 3A-like (without C2 domains) 0.865502
CCND2 cyclin D2 0.863865
MYOG myogenin (myogenic factor 4) 0.856905
KCTD21 potassium channel tetramerization domain containing 21 0.851173
GLYCTK glycerate kinase 0.851173
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1 0.846259
PRDM13 PR domain containing 13 0.842163
GDF7 growth differentiation factor 7 0.838066
DMBT1 deleted in malignant brain tumors 1 0.832738
PTEN phosphatase and tensin homolog 0.832738
SOX2 SRY (sex determining region Y)-box 2 0.827819
REST RE1-silencing transcription factor 0.826999
KMT2B lysine (K)-specific methyltransferase 2B 0.825358
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.817565
ZMYM3 zinc finger, MYM-type 3 0.811001
GLI3 GLI family zinc finger 3 0.799513
ERBB4 erb-b2 receptor tyrosine kinase 4 0.788442
SRP72 signal recognition particle 72kDa 0.78066
IGF1 insulin-like growth factor 1 (somatomedin C) 0.770435
CREBZF CREB/ATF bZIP transcription factor 0.760231
SFRP1 secreted frizzled-related protein 1 0.752085
IRS1 insulin receptor substrate 1 0.74883
KDM6A lysine (K)-specific demethylase 6A 0.743954
MXI1 MAX interactor 1, dimerization protein 0.73746
OR4C12 olfactory receptor, family 4, subfamily C, member 12 0.735838
OTX1 orthodenticle homeobox 1 0.725716
HGFAC HGF activator 0.722886
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.715215
CCAR1 cell division cycle and apoptosis regulator 1 0.715215
MB myoglobin 0.715215
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.709975
CHGA chromogranin A 0.708767
SRRM4 serine/arginine repetitive matrix 4 0.708767
SOX4 SRY (sex determining region Y)-box 4 0.704742
CDKN2A cyclin-dependent kinase inhibitor 2A 0.701928
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.699517
C9ORF78 chromosome 9 open reading frame 78 0.699116
TGIF2 TGFB-induced factor homeobox 2 0.694702
ERBB3 erb-b2 receptor tyrosine kinase 3 0.691495
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.690694
NRBP2 nuclear receptor binding protein 2 0.689893
KCTD6 potassium channel tetramerization domain containing 6 0.687891
CLDN6 claudin 6 0.683093
SLITRK3 SLIT and NTRK-like family, member 3 0.683093
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 0.682693
NTF3 neurotrophin 3 0.682294
PCNA proliferating cell nuclear antigen 0.67551
NEO1 neogenin 1 0.674713
SST somatostatin 0.671527
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.664769
GRM4 glutamate receptor, metabotropic 4 0.662387
MYOD1 myogenic differentiation 1 0.658026
IL13RA2 interleukin 13 receptor, alpha 2 0.650508
HDAC9 histone deacetylase 9 0.648928
SAMD3 sterile alpha motif domain containing 3 0.644981
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.644586
HES1 hes family bHLH transcription factor 1 0.641039
GRIN3B glutamate receptor, ionotropic, N-methyl-D-aspartate 3B 0.63907
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 0.635921
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 0.631205
APC2 adenomatosis polyposis coli 2 0.631205
FAM195A family with sequence similarity 195, member A 0.630813
OLIG2 oligodendrocyte lineage transcription factor 2 0.629242
ZNF638 zinc finger protein 638 0.62728
MELK maternal embryonic leucine zipper kinase 0.624143
MTOR mechanistic target of rapamycin (serine/threonine kinase) 0.619834
IGF1R insulin-like growth factor 1 receptor 0.618268
CASP3 caspase 3, apoptosis-related cysteine peptidase 0.616703
BCOR BCL6 corepressor 0.610448
ANKRD12 ankyrin repeat domain 12 0.607323
CDK6 cyclin-dependent kinase 6 0.606933
ZIC4 Zic family member 4 0.606543
FAM131B family with sequence similarity 131, member B 0.604591
FAXDC2 fatty acid hydroxylase domain containing 2 0.60303
OVCA2 ovarian tumor suppressor candidate 2 0.60069
NEUROD2 neuronal differentiation 2 0.59913
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.59913
TOP1 topoisomerase (DNA) I 0.597961
IGF2 insulin-like growth factor 2 0.596792
AURKA aurora kinase A 0.592506
NHLH1 nescient helix loop helix 1 0.592116
GRIK4 glutamate receptor, ionotropic, kainate 4 0.590558
AGO2 argonaute RISC catalytic component 2 0.585108
DPYSL3 dihydropyrimidinase-like 3 0.583163
WT1 Wilms tumor 1 0.582384
AKNA AT-hook transcription factor 0.57655
MCM9 minichromosome maintenance complex component 9 0.574994
SSTR2 somatostatin receptor 2 0.574994
MET MET proto-oncogene, receptor tyrosine kinase 0.569941
DIS3L DIS3 like exosome 3'-5' exoribonuclease 0.569941
BIRC5 baculoviral IAP repeat containing 5 0.56722
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.563335
BCL2L1 BCL2-like 1 0.563335
UBE2J1 ubiquitin-conjugating enzyme E2, J1 0.563335
PVRL3 poliovirus receptor-related 3 0.557509
SLITRK2 SLIT and NTRK-like family, member 2 0.55712
MED14 mediator complex subunit 14 0.556732
DPH1 diphthamide biosynthesis 1 0.55518
DICER1 dicer 1, ribonuclease type III 0.550911
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.550522
PARP1 poly (ADP-ribose) polymerase 1 0.549747
BRD4 bromodomain containing 4 0.548195
TUBG2 tubulin, gamma 2 0.542767
GPS2 G protein pathway suppressor 2 0.541992
ZNF157 zinc finger protein 157 0.540829
STAT2 signal transducer and activator of transcription 2, 113kDa 0.535796
TNC tenascin C 0.535022
KDM7A lysine (K)-specific demethylase 7A 0.534635
ALPPL2 alkaline phosphatase, placental-like 2 0.527676
ALPP alkaline phosphatase, placental 0.52729
ALPL alkaline phosphatase, liver/bone/kidney 0.526518
DES desmin 0.526132
PCGF2 polycomb group ring finger 2 0.524202
FBXW10 F-box and WD repeat domain containing 10 0.522273
CADPS Ca++-dependent secretion activator 0.522273
JKAMP JNK1/MAPK8-associated membrane protein 0.521117
LINC00207 long intergenic non-protein coding RNA 207 0.521117
NUMBL numb homolog (Drosophila)-like 0.516879
GAS7 growth arrest-specific 7 0.51611
HNF4A hepatocyte nuclear factor 4, alpha 0.51611
BAX BCL2-associated X protein 0.51534
ZIC2 Zic family member 2 0.514956
SLITRK4 SLIT and NTRK-like family, member 4 0.514956
GFI1B growth factor independent 1B transcription repressor 0.512264
SLITRK5 SLIT and NTRK-like family, member 5 0.51188
NEURL1 neuralized E3 ubiquitin protein ligase 1 0.509192
NF2 neurofibromin 2 (merlin) 0.508424
ZIC5 Zic family member 5 0.504207
CD34 CD34 molecule 0.503441
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 0.499997
NF1 neurofibromin 1 0.499231
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.498085
FOXG1 forkhead box G1 0.495411
MIR183 microRNA 183 0.495029
RB1 retinoblastoma 1 0.494648
KDM6B lysine (K)-specific demethylase 6B 0.493503
CFLAR CASP8 and FADD-like apoptosis regulator 0.49274
MXD4 MAX dimerization protein 4 0.490454
NEUROG1 neurogenin 1 0.484364
INA internexin neuronal intermediate filament protein, alpha 0.483224
PAX2 paired box 2 0.475255
ARID1A AT rich interactive domain 1A (SWI-like) 0.474498
HRAS Harvey rat sarcoma viral oncogene homolog 0.471468
BSG basigin (Ok blood group) 0.468063
TIMP3 TIMP metallopeptidase inhibitor 3 0.466928
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.46655
DOCK6 dedicator of cytokinesis 6 0.465794
TICAM2 toll-like receptor adaptor molecule 2 0.464283
TTF1 transcription termination factor, RNA polymerase I 0.463149
EN1 engrailed homeobox 1 0.463149
MAP4 microtubule-associated protein 4 0.462016
ASCL1 achaete-scute family bHLH transcription factor 1 0.460883
KIAA1549 KIAA1549 0.460129
AFP alpha-fetoprotein 0.457109
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.453716
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.452585
BHLHE23 basic helix-loop-helix family, member e23 0.451078
PAX6 paired box 6 0.449194
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.448817
GNRH2 gonadotropin-releasing hormone 2 0.445052
CRX cone-rod homeobox 0.43753
YAP1 Yes-associated protein 1 0.434524
MAPT microtubule-associated protein tau 0.431894
SLITRK6 SLIT and NTRK-like family, member 6 0.431519
PHF19 PHD finger protein 19 0.429642
LYAR Ly1 antibody reactive 0.42814
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.426265
TUBG1 tubulin, gamma 1 0.425514
SAP18 Sin3A-associated protein, 18kDa 0.420641
C17ORF49 chromosome 17 open reading frame 49 0.420641
MXD3 MAX dimerization protein 3 0.420266
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D 0.419517
F13B coagulation factor XIII, B polypeptide 0.418768
RPL30 ribosomal protein L30 0.418394
MKI67 marker of proliferation Ki-67 0.416521
WNT1 wingless-type MMTV integration site family, member 1 0.412779
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.411283
ZNF521 zinc finger protein 521 0.40904
GAGE1 G antigen 1 0.40904
H3F3B H3 histone, family 3B (H3.3B) 0.40904
H3F3A H3 histone, family 3A 0.40904
VIM vimentin 0.408666
FREM3 FRAS1 related extracellular matrix 3 0.406425
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.406051
NNAT neuronatin 0.405305
MMP9 matrix metallopeptidase 9 0.403811
CCM2 cerebral cavernous malformation 2 0.402318
MPRIP myosin phosphatase Rho interacting protein 0.399334
MYL4 myosin, light chain 4, alkali; atrial, embryonic 0.397843
TERT telomerase reverse transcriptase 0.397471
HK2 hexokinase 2 0.396725
GSK3B glycogen synthase kinase 3 beta 0.396725
MNT MAX network transcriptional repressor 0.396725
PCGF1 polycomb group ring finger 1 0.396353
IGFBP6 insulin-like growth factor binding protein 6 0.394863
ZBTB18 zinc finger and BTB domain containing 18 0.393746
PAX3 paired box 3 0.393746
CDK4 cyclin-dependent kinase 4 0.392257
FAM129A family with sequence similarity 129, member A 0.392257
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.391885
SSR1 signal sequence receptor, alpha 0.391141
KIF3A kinesin family member 3A 0.389281
DNTT DNA nucleotidylexotransferase 0.386679
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 0.383708
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.382594
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.378885
RPS20 ribosomal protein S20 0.378514
DAPK1 death-associated protein kinase 1 0.37555
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B 0.374068
TYRO3 TYRO3 protein tyrosine kinase 0.366671
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.365193
NAP1L4 nucleosome assembly protein 1-like 4 0.365193
NEFM neurofilament, medium polypeptide 0.364824
GAGE12I G antigen 12I 0.364085
SOX10 SRY (sex determining region Y)-box 10 0.362609
CD44 CD44 molecule (Indian blood group) 0.358551
FASLG Fas ligand (TNF superfamily, member 6) 0.356341
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 0.354868
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.353763
BCORL1 BCL6 corepressor-like 1 0.352659
SCYL1 SCY1-like 1 (S. cerevisiae) 0.351187
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 0.35082
SNED1 sushi, nidogen and EGF-like domains 1 0.349349
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 0.349349
PBRM1 polybromo 1 0.347879
CCNB1 cyclin B1 0.345675
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.345675
TP73 tumor protein p73 0.343106
PAX7 paired box 7 0.342372
NELL2 NEL-like 2 (chicken) 0.342372
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 0.342006
BCCIP BRCA2 and CDKN1A interacting protein 0.341272
MXD1 MAX dimerization protein 1 0.340173
MAGEA1 melanoma antigen family A1 0.339806
NFIA nuclear factor I/A 0.339073
GADD45A growth arrest and DNA-damage-inducible, alpha 0.338707
ANXA5 annexin A5 0.338707
FOXF1 forkhead box F1 0.335046
GLUL glutamate-ammonia ligase 0.333583
ADGRG2 adhesion G protein-coupled receptor G2 0.332121
RBM14 RNA binding motif protein 14 0.33066
TGDS TDP-glucose 4,6-dehydratase 0.33066
JAG1 jagged 1 0.330295
FADD Fas (TNFRSF6)-associated via death domain 0.328834
PCDHGA10 protocadherin gamma subfamily A, 10 0.326646
ELAVL2 ELAV like neuron-specific RNA binding protein 2 0.325916
HIST2H3PS2 histone cluster 2, H3, pseudogene 2 0.325552
GRIK1 glutamate receptor, ionotropic, kainate 1 0.324458
THBS4 thrombospondin 4 0.322273
ZFAT zinc finger and AT hook domain containing 0.321181
MEIS1 Meis homeobox 1 0.320454
EN2 engrailed homeobox 2 0.318999
PPAP2B phosphatidic acid phosphatase type 2B 0.318635
LIFR leukemia inhibitory factor receptor alpha 0.318272
MYT1L myelin transcription factor 1-like 0.317909
ACTL6A actin-like 6A 0.317182
BCL2 B-cell CLL/lymphoma 2 0.315729
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.313915
MAP1B microtubule-associated protein 1B 0.313552
HHIP hedgehog interacting protein 0.313552
FOS FBJ murine osteosarcoma viral oncogene homolog 0.310652
FGF2 fibroblast growth factor 2 (basic) 0.308842
DBF4 DBF4 zinc finger 0.30848
PRC1 protein regulator of cytokinesis 1 0.307395
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.307033
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.305587
NANOG Nanog homeobox 0.305226
SLCO6A1 solute carrier organic anion transporter family, member 6A1 0.305226
HSPB1 heat shock 27kDa protein 1 0.30342
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 0.303059
CDK14 cyclin-dependent kinase 14 0.302337
CCNB3 cyclin B3 0.301976
LIN28B lin-28 homolog B (C. elegans) 0.300894
S100P S100 calcium binding protein P 0.300894
KLF10 Kruppel-like factor 10 0.300894
LIG4 ligase IV, DNA, ATP-dependent 0.300173
PDGFB platelet-derived growth factor beta polypeptide 0.299452
PRDX3 peroxiredoxin 3 0.299452
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.297651
CIZ1 CDKN1A interacting zinc finger protein 1 0.296931
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.295132
JUP junction plakoglobin 0.295132
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.292975
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 0.291898
GMFB glia maturation factor, beta 0.290821
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) 0.289027
CIC capicua transcriptional repressor 0.288668
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.28831
GSTP1 glutathione S-transferase pi 1 0.287952
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 0.287952
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.286519
MMP2 matrix metallopeptidase 2 0.284371
IGFBP3 insulin-like growth factor binding protein 3 0.283655
EP300 E1A binding protein p300 0.282582
RPL7A ribosomal protein L7a 0.280082
SOX11 SRY (sex determining region Y)-box 11 0.27794
NEUROD1 neuronal differentiation 1 0.27687
VEGFA vascular endothelial growth factor A 0.275801
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.274732
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.273664
RICTOR RPTOR independent companion of MTOR, complex 2 0.272597
NKX2-2 NK2 homeobox 2 0.272241
CUL3 cullin 3 0.27153
PAX5 paired box 5 0.270464
PDGFD platelet derived growth factor D 0.269398
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.269043
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 0.267622
UBE4B ubiquitination factor E4B 0.266558
BCAS3 breast carcinoma amplified sequence 3 0.266203
PID1 phosphotyrosine interaction domain containing 1 0.264785
PLCB2 phospholipase C, beta 2 0.264431
CDK20 cyclin-dependent kinase 20 0.261952
LSAMP limbic system-associated membrane protein 0.25983
HNRNPF heterogeneous nuclear ribonucleoprotein F 0.257005
FRS2 fibroblast growth factor receptor substrate 2 0.256299
OMA1 OMA1 zinc metallopeptidase 0.255946
ADAM8 ADAM metallopeptidase domain 8 0.255594
CERS4 ceramide synthase 4 0.255241
TGFB1 transforming growth factor, beta 1 0.254183
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.254183
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.253479
SOX9 SRY (sex determining region Y)-box 9 0.248554
PDGFC platelet derived growth factor C 0.247852
ELAVL1 ELAV like RNA binding protein 1 0.247501
TGFB2 transforming growth factor, beta 2 0.247501
MNX1 motor neuron and pancreas homeobox 1 0.245046
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.244696
SOCS6 suppressor of cytokine signaling 6 0.244345
GJA1 gap junction protein, alpha 1, 43kDa 0.243645
IL2 interleukin 2 0.243295
KDM2B lysine (K)-specific demethylase 2B 0.242245
FUBP1 far upstream element (FUSE) binding protein 1 0.241895
TSC2 tuberous sclerosis 2 0.240497
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1 0.240148
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 0.239799
FOXM1 forkhead box M1 0.239799
MAGEA4 melanoma antigen family A4 0.239799
IHH indian hedgehog 0.23945
LHX1 LIM homeobox 1 0.238752
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.237009
GRIN3A glutamate receptor, ionotropic, N-methyl-D-aspartate 3A 0.23666
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.236312
CLTB clathrin, light chain B 0.234573
S100A10 S100 calcium binding protein A10 0.234225
RAB18 RAB18, member RAS oncogene family 0.232836
SNAI2 snail family zinc finger 2 0.232836
SYCP1 synaptonemal complex protein 1 0.232142
ASXL2 additional sex combs like transcriptional regulator 2 0.231448
FBXL15 F-box and leucine-rich repeat protein 15 0.22937
GPR68 G protein-coupled receptor 68 0.229024
PDGFA platelet-derived growth factor alpha polypeptide 0.228333
GFI1 growth factor independent 1 transcription repressor 0.228333
ERAS ES cell expressed Ras 0.228333
SOX8 SRY (sex determining region Y)-box 8 0.227642
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.225229
STAT1 signal transducer and activator of transcription 1, 91kDa 0.224884
MATR3 matrin 3 0.224196
TOP3A topoisomerase (DNA) III alpha 0.223509
LASP1 LIM and SH3 protein 1 0.223165
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3 0.222822
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.221793
ESR2 estrogen receptor 2 (ER beta) 0.21974
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.218374
NEUROG2 neurogenin 2 0.217693
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.216332
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 0.214636
FN1 fibronectin 1 0.213959
CALB2 calbindin 2 0.212271
DCX doublecortin 0.210925
NAV3 neuron navigator 3 0.210589
NUMB numb homolog (Drosophila) 0.208579
PARK2 parkin RBR E3 ubiquitin protein ligase 0.208245
RNF2 ring finger protein 2 0.208245
CDC25A cell division cycle 25A 0.207578
HDAC1 histone deacetylase 1 0.205916
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.204593
BRCA2 breast cancer 2, early onset 0.204593
PRKCE protein kinase C, epsilon 0.204593
TMPRSS11D transmembrane protease, serine 11D 0.203933
CDC25C cell division cycle 25C 0.203604
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.203604
MIR186 microRNA 186 0.20229
PIWIL2 piwi-like RNA-mediated gene silencing 2 0.200982
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 0.200331
TNR tenascin R 0.199681
PIKFYVE phosphoinositide kinase, FYVE finger containing 0.199681
KITLG KIT ligand 0.199356
MAGEA12 melanoma antigen family A12 0.198709
NAT10 N-acetyltransferase 10 (GCN5-related) 0.19742
PRAME preferentially expressed antigen in melanoma 0.196779
CA2 carbonic anhydrase II 0.196779
ZNF148 zinc finger protein 148 0.196779
KLK15 kallikrein-related peptidase 15 0.196139
STRADA STE20-related kinase adaptor alpha 0.19582
NMBR neuromedin B receptor 0.19582
CROCC ciliary rootlet coiled-coil, rootletin 0.195501
PHLDA2 pleckstrin homology-like domain, family A, member 2 0.195183
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.191408
ATG5 autophagy related 5 0.190168
JARID2 jumonji, AT rich interactive domain 2 0.189244
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 0.189244
F3 coagulation factor III (thromboplastin, tissue factor) 0.188326
HLA-B major histocompatibility complex, class I, B 0.187415
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 0.18621
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.185612
MSH6 mutS homolog 6 0.182086
HOXB3 homeobox B3 0.180084
ASPH aspartate beta-hydroxylase 0.17952
B2M beta-2-microglobulin 0.178403
CD164 CD164 molecule, sialomucin 0.178126
MMP10 matrix metallopeptidase 10 0.177301
PLAU plasminogen activator, urokinase 0.176485
BDNF brain-derived neurotrophic factor 0.175947
SACK1H scaffolding CK1 anchoring protein H 0.175679
MSI2 musashi RNA-binding protein 2 0.174881
DAXX death-domain associated protein 0.174617
PLK1 polo-like kinase 1 0.174354
GDI2 GDP dissociation inhibitor 2 0.173832
BMP4 bone morphogenetic protein 4 0.173832
CARD17 caspase recruitment domain family, member 17 0.173832
FBXO44 F-box protein 44 0.173314
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.171535
MYLIP myosin regulatory light chain interacting protein 0.171286
HES5 hes family bHLH transcription factor 5 0.16933
JAG2 jagged 2 0.168617
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 0.168381
FOXL1 forkhead box L1 0.168148
MAGEA3 melanoma antigen family A3 0.167224
FABP3 fatty acid binding protein 3, muscle and heart 0.166995
IRS4 insulin receptor substrate 4 0.165655
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.165655
FGF1 fibroblast growth factor 1 (acidic) 0.165217
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.165001
MARK2 MAP/microtubule affinity-regulating kinase 2 0.165001
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 0.164786
GSTA3 glutathione S-transferase alpha 3 0.164571
GSTA2 glutathione S-transferase alpha 2 0.163938
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 0.163729
GSTA4 glutathione S-transferase alpha 4 0.163317
CNTN5 contactin 5 0.162908
EEF2K eukaryotic elongation factor 2 kinase 0.162707
FLT1 fms-related tyrosine kinase 1 0.162505
PTER phosphotriesterase related 0.162306
HPSE heparanase 0.162306
APOD apolipoprotein D 0.162306
ZIC3 Zic family member 3 0.161912
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5 0.160948
FZD10 frizzled class receptor 10 0.160574
GSTA1 glutathione S-transferase alpha 1 0.160203
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 0.159838
MAGEA10 melanoma antigen family A10 0.159658
CREBBP CREB binding protein 0.159124
KDR kinase insert domain receptor 0.158778
GRP gastrin-releasing peptide 0.158778
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon 0.157929
VIPR2 vasoactive intestinal peptide receptor 2 0.157765
PHF20 PHD finger protein 20 0.144094
APOPT1 apoptogenic 1, mitochondrial 0.143832
SH3GL1 SH3-domain GRB2-like 1 0.137393
UNC5B unc-5 homolog B (C. elegans) 0.136595
TP63 tumor protein p63 0.136162
ATG12 autophagy related 12 0.134333
ANK1 ankyrin 1, erythrocytic 0.133821
ADRB2 adrenoceptor beta 2, surface 0.132574
EPHB2 EPH receptor B2 0.131392
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 0.12959
RHO rhodopsin 0.127758
NTN1 netrin 1 0.126931
ATG7 autophagy related 7 0.126574
NEFH neurofilament, heavy polypeptide 0.125072
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.12484
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.122178
OGG1 8-oxoguanine DNA glycosylase 0.119531
CDK2 cyclin-dependent kinase 2 0.118922
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 0.117591
BMP7 bone morphogenetic protein 7 0.117435
GH1 growth hormone 1 0.117122
DIABLO diablo, IAP-binding mitochondrial protein 0.113442
NRG1 neuregulin 1 0.113223
PTGDS prostaglandin D2 synthase 21kDa (brain) 0.111603
HPGDS hematopoietic prostaglandin D synthase 0.110822
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 0.110423
IL6 interleukin 6 0.103879