medulloblastoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)|A malignant, invasive embryonal neoplasm arising from the cerebellum. It occurs predominantly in children and has the tendency to metastasize via the cerebrospinal fluid pathways. Signs and symptoms include truncal ataxia, disturbed gait, lethargy, headache, and vomiting. There are four histologic variants: classic medulloblastoma, desmoplastic medulloblastoma, large cell medulloblastoma, and medulloblastoma with extensive nodularity and advanced neuronal differentiation. (from NCI Thesuarus) (Experimental Factor Ontology, EFO_0002939)
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Genes

209 genes co-occuring with the biological term medulloblastoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADAM8 ADAM metallopeptidase domain 8
AHR aryl hydrocarbon receptor
ALK anaplastic lymphoma receptor tyrosine kinase
AMH anti-Mullerian hormone
APC adenomatous polyposis coli
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
AXIN1 axin 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BDNF brain-derived neurotrophic factor
BIRC5 baculoviral IAP repeat containing 5
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMP7 bone morphogenetic protein 7
BRCA1 breast cancer 1, early onset
BRD4 bromodomain containing 4
BTG2 BTG family, member 2
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCM2 cerebral cavernous malformation 2
CCNB1 cyclin B1
CCND1 cyclin D1
CCND2 cyclin D2
CD164 CD164 molecule, sialomucin
CDK6 cyclin-dependent kinase 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CIC capicua transcriptional repressor
COL1A2 collagen, type I, alpha 2
CRABP2 cellular retinoic acid binding protein 2
CREBBP CREB binding protein
CREBZF CREB/ATF bZIP transcription factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CXCR4 chemokine (C-X-C motif) receptor 4
DAB2IP DAB2 interacting protein
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLL1 delta-like 1 (Drosophila)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FGF6 fibroblast growth factor 6
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FOXG1 forkhead box G1
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FRZB frizzled-related protein
FSTL5 follistatin-like 5
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
GADD45A growth arrest and DNA-damage-inducible, alpha
GFI1 growth factor independent 1 transcription repressor
GFI1B growth factor independent 1B transcription repressor
GLI1 GLI family zinc finger 1
GLI3 GLI family zinc finger 3
GRK6 G protein-coupled receptor kinase 6
GRPR gastrin-releasing peptide receptor
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HAND1 heart and neural crest derivatives expressed 1
HES1 hes family bHLH transcription factor 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HHIP hedgehog interacting protein
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
HPSE heparanase
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL17A interleukin 17A
INHBB inhibin, beta B
ISG15 ISG15 ubiquitin-like modifier
ITGA9 integrin, alpha 9
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAG1 jagged 1
JAG2 jagged 2
JUP junction plakoglobin
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCNK9 potassium channel, two pore domain subfamily K, member 9
KCTD11 potassium channel tetramerization domain containing 11
KCTD21 potassium channel tetramerization domain containing 21
KCTD6 potassium channel tetramerization domain containing 6
KDM1A lysine (K)-specific demethylase 1A
KDM6A lysine (K)-specific demethylase 6A
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIF14 kinesin family member 14
KIF1B kinesin family member 1B
KLF4 Kruppel-like factor 4 (gut)
LASP1 LIM and SH3 protein 1
LDHB lactate dehydrogenase B
MAPK1 mitogen-activated protein kinase 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM7 minichromosome maintenance complex component 7
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MGMT O-6-methylguanine-DNA methyltransferase
MIR124-1 microRNA 124-1
MIR148A microRNA 148a
MIR17HG miR-17-92 cluster host gene
MIR199B microRNA 199b
MIR218-1 microRNA 218-1
MIR218-2 microRNA 218-2
MIR219A1 microRNA 219a-1
MIR224 microRNA 224
MIR23B microRNA 23b
MIR34A microRNA 34a
MIR383 microRNA 383
MIR9-1 microRNA 9-1
MKI67 marker of proliferation Ki-67
MMP9 matrix metallopeptidase 9
MSI1 musashi RNA-binding protein 1
MSI2 musashi RNA-binding protein 2
MXD3 MAX dimerization protein 3
MXI1 MAX interactor 1, dimerization protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
MYOD1 myogenic differentiation 1
NBN nibrin
NEO1 neogenin 1
NEURL1 neuralized E3 ubiquitin protein ligase 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NGFR nerve growth factor receptor
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NT5E 5'-nucleotidase, ecto (CD73)
NTF3 neurotrophin 3
NTN1 netrin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTRK3 neurotrophic tyrosine kinase, receptor, type 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OTX2 orthodenticle homeobox 2
PAX2 paired box 2
PCDH10 protocadherin 10
PCGF2 polycomb group ring finger 2
PDE4A phosphodiesterase 4A, cAMP-specific
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PID1 phosphotyrosine interaction domain containing 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLK1 polo-like kinase 1
POU5F1 POU class 5 homeobox 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRDX3 peroxiredoxin 3
PROM1 prominin 1
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
REST RE1-silencing transcription factor
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPL30 ribosomal protein L30
RPS20 ribosomal protein S20
S100A4 S100 calcium binding protein A4
SCG5 secretogranin V
SFRP1 secreted frizzled-related protein 1
SFRP2 secreted frizzled-related protein 2
SGK1 serum/glucocorticoid regulated kinase 1
SH3GL1 SH3-domain GRB2-like 1
SHH sonic hedgehog
SIRT1 sirtuin 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SNAI1 snail family zinc finger 1
SOX2 SRY (sex determining region Y)-box 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSTR2 somatostatin receptor 2
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK25 serine/threonine kinase 25
STMN1 stathmin 1
SUFU suppressor of fused homolog (Drosophila)
TBK1 TANK-binding kinase 1
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TNC tenascin C
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP73 tumor protein p73
USP9X ubiquitin specific peptidase 9, X-linked
VEGFA vascular endothelial growth factor A
WEE1 WEE1 G2 checkpoint kinase
WNT1 wingless-type MMTV integration site family, member 1
WNT3 wingless-type MMTV integration site family, member 3
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
YAP1 Yes-associated protein 1
ZNF521 zinc finger protein 521