mefexamide-2121 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the mefexamide-2121 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ACOX3 acyl-CoA oxidase 3, pristanoyl
AHI1 Abelson helper integration site 1
AK1 adenylate kinase 1
ANKRD12 ankyrin repeat domain 12
APP amyloid beta (A4) precursor protein
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ASMTL acetylserotonin O-methyltransferase-like
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCHE butyrylcholinesterase
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
C16ORF59 chromosome 16 open reading frame 59
C1ORF21 chromosome 1 open reading frame 21
CEP164 centrosomal protein 164kDa
CSF1R colony stimulating factor 1 receptor
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DCTN1 dynactin 1
DHODH dihydroorotate dehydrogenase (quinone)
DLG3 discs, large homolog 3 (Drosophila)
DTX3 deltex 3, E3 ubiquitin ligase
EPHA4 EPH receptor A4
ETV5 ets variant 5
FGF5 fibroblast growth factor 5
FGFR4 fibroblast growth factor receptor 4
GAL3ST4 galactose-3-O-sulfotransferase 4
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GOLGA2 golgin A2
HNMT histamine N-methyltransferase
HOOK1 hook microtubule-tethering protein 1
IFI6 interferon, alpha-inducible protein 6
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
INSIG1 insulin induced gene 1
JUND jun D proto-oncogene
KIAA0754 KIAA0754
KIRREL kin of IRRE like (Drosophila)
KRIT1 KRIT1, ankyrin repeat containing
LDB1 LIM domain binding 1
LINC00339 long intergenic non-protein coding RNA 339
LRP6 low density lipoprotein receptor-related protein 6
MANBA mannosidase, beta A, lysosomal
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MDFI MyoD family inhibitor
MDFIC MyoD family inhibitor domain containing
MMP9 matrix metallopeptidase 9
MTUS1 microtubule associated tumor suppressor 1
MUC3A mucin 3A, cell surface associated
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)
NOL12 nucleolar protein 12
NOP14-AS1 NOP14 antisense RNA 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCBP2 poly(rC) binding protein 2
PCDH11Y protocadherin 11 Y-linked
PCIF1 PDX1 C-terminal inhibiting factor 1
PCSK7 proprotein convertase subtilisin/kexin type 7
PEX26 peroxisomal biogenesis factor 26
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PRKRIP1 PRKR interacting protein 1 (IL11 inducible)
PRPF18 pre-mRNA processing factor 18
PTGDR2 prostaglandin D2 receptor 2
PTPN21 protein tyrosine phosphatase, non-receptor type 21
PWAR5 Prader Willi/Angelman region RNA 5
RAB27B RAB27B, member RAS oncogene family
RBM19 RNA binding motif protein 19
REST RE1-silencing transcription factor
RGS10 regulator of G-protein signaling 10
RGS14 regulator of G-protein signaling 14
RHOBTB2 Rho-related BTB domain containing 2
S100A11 S100 calcium binding protein A11
S100A3 S100 calcium binding protein A3
SIRT5 sirtuin 5
SLC48A1 solute carrier family 48 (heme transporter), member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
STAG3 stromal antigen 3
STK4 serine/threonine kinase 4
STS steroid sulfatase (microsomal), isozyme S
SYNE1 spectrin repeat containing, nuclear envelope 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TAGLN3 transgelin 3
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLE3 transducin-like enhancer of split 3
TMBIM1 transmembrane BAX inhibitor motif containing 1
TMEM180 transmembrane protein 180
TMEM63A transmembrane protein 63A
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRAPPC10 trafficking protein particle complex 10
TRIM14 tripartite motif containing 14
TSPAN1 tetraspanin 1
VEGFB vascular endothelial growth factor B
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB22 zinc finger and BTB domain containing 22
ZBTB43 zinc finger and BTB domain containing 43
ZNF444 zinc finger protein 444
ZNF747 zinc finger protein 747

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ABHD4 abhydrolase domain containing 4
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BCL2L2 BCL2-like 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLMH bleomycin hydrolase
BNC1 basonuclin 1
C9ORF40 chromosome 9 open reading frame 40
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CCNJL cyclin J-like
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CEP97 centrosomal protein 97kDa
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12
CIDEC cell death-inducing DFFA-like effector c
CLSPN claspin
CORO2A coronin, actin binding protein, 2A
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPVL carboxypeptidase, vitellogenic-like
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
EDC4 enhancer of mRNA decapping 4
EDN1 endothelin 1
ERCC5 excision repair cross-complementation group 5
FBXL15 F-box and leucine-rich repeat protein 15
FBXO2 F-box protein 2
FMO4 flavin containing monooxygenase 4
GLDC glycine dehydrogenase (decarboxylating)
HINFP histone H4 transcription factor
HIRA histone cell cycle regulator
HIST2H2AA3 histone cluster 2, H2aa3
HMGB3P1 high mobility group box 3 pseudogene 1
HOXB9 homeobox B9
HSPA1L heat shock 70kDa protein 1-like
HYI hydroxypyruvate isomerase (putative)
IL4R interleukin 4 receptor
INPPL1 inositol polyphosphate phosphatase-like 1
IRF2BP1 interferon regulatory factor 2 binding protein 1
KDM5C lysine (K)-specific demethylase 5C
KLF3 Kruppel-like factor 3 (basic)
KRT8P12 keratin 8 pseudogene 12
LAMC3 laminin, gamma 3
LMCD1 LIM and cysteine-rich domains 1
LRRC61 leucine rich repeat containing 61
MAGEH1 melanoma antigen family H1
MOSPD3 motile sperm domain containing 3
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
NACA2 nascent polypeptide-associated complex alpha subunit 2
NCS1 neuronal calcium sensor 1
NDRG4 NDRG family member 4
NR1H3 nuclear receptor subfamily 1, group H, member 3
NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11
OLFML2A olfactomedin-like 2A
PHACTR4 phosphatase and actin regulator 4
PLAC8 placenta-specific 8
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PMCH pro-melanin-concentrating hormone
POM121 POM121 transmembrane nucleoporin
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PSKH1 protein serine kinase H1
QSER1 glutamine and serine rich 1
RAB4B RAB4B, member RAS oncogene family
RANBP17 RAN binding protein 17
RNF2 ring finger protein 2
RPRD2 regulation of nuclear pre-mRNA domain containing 2
RPUSD2 RNA pseudouridylate synthase domain containing 2
SAMD9 sterile alpha motif domain containing 9
SECTM1 secreted and transmembrane 1
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHPK sedoheptulokinase
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SYT17 synaptotagmin XVII
THBS3 thrombospondin 3
TIPRL TOR signaling pathway regulator
TMEM121 transmembrane protein 121
TMEM159 transmembrane protein 159
TMEM183A transmembrane protein 183A
TMEM8B transmembrane protein 8B
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRIM66 tripartite motif containing 66
TSPAN8 tetraspanin 8
TUBA3D tubulin, alpha 3d
TUBB2B tubulin, beta 2B class IIb
TXLNG taxilin gamma
WDR43 WD repeat domain 43
WNT5B wingless-type MMTV integration site family, member 5B
ZNF141 zinc finger protein 141
ZNF180 zinc finger protein 180
ZNF8 zinc finger protein 8
ZSCAN26 zinc finger and SCAN domain containing 26