mefexamide-2284 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the mefexamide-2284 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ACTL8 actin-like 8
ADGRL3 adhesion G protein-coupled receptor L3
AIM1L absent in melanoma 1-like
AKAP1 A kinase (PRKA) anchor protein 1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARHGAP26 Rho GTPase activating protein 26
BIN1 bridging integrator 1
BMP10 bone morphogenetic protein 10
C1ORF54 chromosome 1 open reading frame 54
C1QL1 complement component 1, q subcomponent-like 1
CAPN10 calpain 10
CCR2 chemokine (C-C motif) receptor 2
CD300A CD300a molecule
CD47 CD47 molecule
CD53 CD53 molecule
CD70 CD70 molecule
CDADC1 cytidine and dCMP deaminase domain containing 1
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CELF2 CUGBP, Elav-like family member 2
CFLAR CASP8 and FADD-like apoptosis regulator
CHD5 chromodomain helicase DNA binding protein 5
CLIC5 chloride intracellular channel 5
CNTFR ciliary neurotrophic factor receptor
CTSF cathepsin F
DFNB31 deafness, autosomal recessive 31
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DPF1 D4, zinc and double PHD fingers family 1
DRD2 dopamine receptor D2
DST dystonin
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GJA8 gap junction protein, alpha 8, 50kDa
GLRX3 glutaredoxin 3
GOLGA8A golgin A8 family, member A
GPM6A glycoprotein M6A
GPR162 G protein-coupled receptor 162
GPR182 G protein-coupled receptor 182
GREB1L growth regulation by estrogen in breast cancer-like
GRIK1 glutamate receptor, ionotropic, kainate 1
GYG2 glycogenin 2
HCG4 HLA complex group 4 (non-protein coding)
HOXA9 homeobox A9
HOXB2 homeobox B2
IBSP integrin-binding sialoprotein
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
INA internexin neuronal intermediate filament protein, alpha
IRF5 interferon regulatory factor 5
KLHL35 kelch-like family member 35
LRRC6 leucine rich repeat containing 6
LTBP4 latent transforming growth factor beta binding protein 4
MAN1A2 mannosidase, alpha, class 1A, member 2
MARK4 MAP/microtubule affinity-regulating kinase 4
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MIER2 mesoderm induction early response 1, family member 2
MNMIP1 manchette microtubule inner protein 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCF4 neutrophil cytosolic factor 4, 40kDa
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEU3 sialidase 3 (membrane sialidase)
NKX2-8 NK2 homeobox 8
NPR3 natriuretic peptide receptor 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
OGDHL oxoglutarate dehydrogenase-like
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
PALM paralemmin
PAX2 paired box 2
PCDH1 protocadherin 1
PCDH9 protocadherin 9
PCDHA9 protocadherin alpha 9
PDE4DIP phosphodiesterase 4D interacting protein
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDIA2 protein disulfide isomerase family A, member 2
PDLIM4 PDZ and LIM domain 4
PORCN porcupine homolog (Drosophila)
POU1F1 POU class 1 homeobox 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRODH2 proline dehydrogenase (oxidase) 2
PRX periaxin
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RGS10 regulator of G-protein signaling 10
RMND5A required for meiotic nuclear division 5 homolog A (S. cerevisiae)
RNF122 ring finger protein 122
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SFTPB surfactant protein B
SZT2 seizure threshold 2 homolog (mouse)
TBL2 transducin (beta)-like 2
TIMP3 TIMP metallopeptidase inhibitor 3
TP53I11 tumor protein p53 inducible protein 11
TPMT thiopurine S-methyltransferase
TRIM29 tripartite motif containing 29
VIPR1 vasoactive intestinal peptide receptor 1
WIPF1 WAS/WASL interacting protein family, member 1
WSCD1 WSC domain containing 1
ZFP64 ZFP64 zinc finger protein
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AFF4 AF4/FMR2 family, member 4
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOLD1 apolipoprotein L domain containing 1
ARHGAP4 Rho GTPase activating protein 4
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
BAHD1 bromo adjacent homology domain containing 1
BCOR BCL6 corepressor
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CALML5 calmodulin-like 5
CD80 CD80 molecule
CD82 CD82 molecule
CEP97 centrosomal protein 97kDa
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CNR2 cannabinoid receptor 2 (macrophage)
CNTN1 contactin 1
COPZ2 coatomer protein complex, subunit zeta 2
CORO7 coronin 7
CST6 cystatin E/M
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DGAT1 diacylglycerol O-acyltransferase 1
DIXDC1 DIX domain containing 1
DNAH17 dynein, axonemal, heavy chain 17
DUSP9 dual specificity phosphatase 9
DVL1 dishevelled segment polarity protein 1
ETV6 ets variant 6
FAM120C family with sequence similarity 120C
FAM212B family with sequence similarity 212, member B
FBXL7 F-box and leucine-rich repeat protein 7
FBXW12 F-box and WD repeat domain containing 12
FMOD fibromodulin
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GBP2 guanylate binding protein 2, interferon-inducible
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR87 G protein-coupled receptor 87
GRTP1 growth hormone regulated TBC protein 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H4D histone cluster 1, H4d
HOXC10 homeobox C10
INHA inhibin, alpha
INO80D INO80 complex subunit D
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIF13B kinesin family member 13B
KRI1 KRI1 homolog (S. cerevisiae)
LAMP3 lysosomal-associated membrane protein 3
LHFPL2 lipoma HMGIC fusion partner-like 2
LYPLA2P1 lysophospholipase II pseudogene 1
MALL mal, T-cell differentiation protein-like
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MFAP2 microfibrillar-associated protein 2
MXD3 MAX dimerization protein 3
N4BP3 NEDD4 binding protein 3
NEUROD4 neuronal differentiation 4
NME5 NME/NM23 family member 5
NPIPB3 nuclear pore complex interacting protein family, member B3
OSMR oncostatin M receptor
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PAIP2B poly(A) binding protein interacting protein 2B
PLCD1 phospholipase C, delta 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLL polymerase (DNA directed), lambda
PRF1 perforin 1 (pore forming protein)
PTGES2 prostaglandin E synthase 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RPGRIP1L RPGRIP1-like
S100A9 S100 calcium binding protein A9
SAYSD1 SAYSVFN motif domain containing 1
SCRN3 secernin 3
SENP7 SUMO1/sentrin specific peptidase 7
SETD1A SET domain containing 1A
SHARPIN SHANK-associated RH domain interactor
SLC16A6 solute carrier family 16, member 6
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNORA21 small nucleolar RNA, H/ACA box 21
STAB2 stabilin 2
STK16 serine/threonine kinase 16
TBC1D17 TBC1 domain family, member 17
THRAP3 thyroid hormone receptor associated protein 3
TLN1 talin 1
TSC22D4 TSC22 domain family, member 4
VLDLR very low density lipoprotein receptor
VWA5A von Willebrand factor A domain containing 5A
WDR62 WD repeat domain 62
YY2 YY2 transcription factor
ZBTB44 zinc finger and BTB domain containing 44
ZFP37 ZFP37 zinc finger protein
ZNF365 zinc finger protein 365
ZNF76 zinc finger protein 76