meglumine-6445 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the meglumine-6445 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADAM22 ADAM metallopeptidase domain 22
ADGB androglobin
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AKAP13 A kinase (PRKA) anchor protein 13
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANXA2P3 annexin A2 pseudogene 3
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP10B ATPase, class V, type 10B
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BGN biglycan
C8ORF4 chromosome 8 open reading frame 4
CALD1 caldesmon 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD6 CD6 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFAP69 cilia and flagella associated protein 69
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRND cholinergic receptor, nicotinic, delta (muscle)
CLDN1 claudin 1
CLDN14 claudin 14
COL10A1 collagen, type X, alpha 1
CSF1R colony stimulating factor 1 receptor
CSNK1G1 casein kinase 1, gamma 1
CYLD cylindromatosis (turban tumor syndrome)
DCAF4 DDB1 and CUL4 associated factor 4
DCTN2 dynactin 2 (p50)
DEF6 differentially expressed in FDCP 6 homolog (mouse)
EDN1 endothelin 1
EFNA5 ephrin-A5
EMX1 empty spiracles homeobox 1
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2
FBLN1 fibulin 1
FLJ11292
FUS FUS RNA binding protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GDF5 growth differentiation factor 5
GIMAP6 GTPase, IMAP family member 6
GLIPR1 GLI pathogenesis-related 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HCRP1 hepatocellular carcinoma-related HCRP1
HFE hemochromatosis
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HLF hepatic leukemia factor
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFFO1 intermediate filament family orphan 1
IFNA8 interferon, alpha 8
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1109 KIAA1109
KLF12 Kruppel-like factor 12
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LDLRAD4 low density lipoprotein receptor class A domain containing 4
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LRP12 low density lipoprotein receptor-related protein 12
MAGOH2P mago-nashi homolog 2, pseudogene
MEG3 maternally expressed 3 (non-protein coding)
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MST1 macrophage stimulating 1
MYLK myosin light chain kinase
NEK9 NIMA-related kinase 9
NPY2R neuropeptide Y receptor Y2
PARP3 poly (ADP-ribose) polymerase family, member 3
PCDHB3 protocadherin beta 3
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDLIM5 PDZ and LIM domain 5
PQLC2 PQ loop repeat containing 2
PRB3 proline-rich protein BstNI subfamily 3
PRKCE protein kinase C, epsilon
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RAB11B RAB11B, member RAS oncogene family
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RGS7 regulator of G-protein signaling 7
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SETD8 SET domain containing (lysine methyltransferase) 8
SGSM3 small G protein signaling modulator 3
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SRPK2 SRSF protein kinase 2
SSTR2 somatostatin receptor 2
SYK spleen tyrosine kinase
TBX6 T-box 6
TCP10 t-complex 10
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TOP3B topoisomerase (DNA) III beta
TSSK2 testis-specific serine kinase 2
TTC38 tetratricopeptide repeat domain 38
TUBA3C tubulin, alpha 3c
TUBA4B tubulin, alpha 4b
VARS valyl-tRNA synthetase
WNT2 wingless-type MMTV integration site family member 2
WSCD1 WSC domain containing 1
ZCCHC24 zinc finger, CCHC domain containing 24

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADAM15 ADAM metallopeptidase domain 15
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALS2CL ALS2 C-terminal like
APOLD1 apolipoprotein L domain containing 1
ASPN asporin
BAG4 BCL2-associated athanogene 4
BCORL1 BCL6 corepressor-like 1
C1ORF159 chromosome 1 open reading frame 159
CALB2 calbindin 2
CD3D CD3d molecule, delta (CD3-TCR complex)
CEP85 centrosomal protein 85kDa
CHRM3 cholinergic receptor, muscarinic 3
CLCA1 chloride channel accessory 1
CNR2 cannabinoid receptor 2 (macrophage)
CTSE cathepsin E
CUL9 cullin 9
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DBR1 debranching RNA lariats 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
EFNA3 ephrin-A3
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPHA2 EPH receptor A2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM155A family with sequence similarity 155, member A
FAM155B family with sequence similarity 155, member B
FAM222B family with sequence similarity 222, member B
FBXL15 F-box and leucine-rich repeat protein 15
FBXL7 F-box and leucine-rich repeat protein 7
FBXO31 F-box protein 31
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FUZ fuzzy planar cell polarity protein
GALK1 galactokinase 1
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GLDC glycine dehydrogenase (decarboxylating)
GLS2 glutaminase 2 (liver, mitochondrial)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR3 G protein-coupled receptor 3
GPR87 G protein-coupled receptor 87
GSTM2 glutathione S-transferase mu 2 (muscle)
HAMP hepcidin antimicrobial peptide
HAND1 heart and neural crest derivatives expressed 1
HIRA histone cell cycle regulator
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KPNA4 karyopherin alpha 4 (importin alpha 3)
KRT13 keratin 13, type I
LOC390998 ribosomal protein L10 pseudogene
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MB myoglobin
MOCS3 molybdenum cofactor synthesis 3
MTERF4 mitochondrial transcription termination factor 4
MUC3A mucin 3A, cell surface associated
NELL2 NEL-like 2 (chicken)
NPM3 nucleophosmin/nucleoplasmin 3
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PACSIN3 protein kinase C and casein kinase substrate in neurons 3
PCDHA9 protocadherin alpha 9
PHEX phosphate regulating endopeptidase homolog, X-linked
PODXL2 podocalyxin-like 2
PROL1 proline rich, lacrimal 1
PRSS16 protease, serine, 16 (thymus)
PRSS53 protease, serine, 53
PTPRU protein tyrosine phosphatase, receptor type, U
PVRL3 poliovirus receptor-related 3
RAB3A RAB3A, member RAS oncogene family
REEP4 receptor accessory protein 4
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF208 ring finger protein 208
RPAP1 RNA polymerase II associated protein 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SETMAR SET domain and mariner transposase fusion gene
SFRP5 secreted frizzled-related protein 5
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SPINK4 serine peptidase inhibitor, Kazal type 4
SPRYD7 SPRY domain containing 7
SYNC syncoilin, intermediate filament protein
THBS3 thrombospondin 3
TMEM212 transmembrane protein 212
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
UBQLN4 ubiquilin 4
UPK3B uroplakin 3B
VASH1 vasohibin 1
VASH2 vasohibin 2
VAV1 vav 1 guanine nucleotide exchange factor
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
WDR76 WD repeat domain 76
ZNF205 zinc finger protein 205
ZNF446 zinc finger protein 446
ZNF516 zinc finger protein 516
ZNF692 zinc finger protein 692
ZNF747 zinc finger protein 747