melanoma Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)|A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain. (Experimental Factor Ontology, EFO_0000756)
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Genes

92 proteins co-occuring with the biological term melanoma in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
BAD BCL2-associated agonist of cell death
BCAR1 breast cancer anti-estrogen resistance 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHEK1 checkpoint kinase 1
CIC capicua transcriptional repressor
CREB1 cAMP responsive element binding protein 1
CSPG4 chondroitin sulfate proteoglycan 4
CXCR2 chemokine (C-X-C motif) receptor 2
DRD2 dopamine receptor D2
EFHD2 EF-hand domain family, member D2
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FBXO31 F-box protein 31
FLNA filamin A, alpha
FOXO4 forkhead box O4
FSCN1 fascin actin-bundling protein 1
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGF1R insulin-like growth factor 1 receptor
ING1 inhibitor of growth family, member 1
JUN jun proto-oncogene
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
MAGEA11 melanoma antigen family A11
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK9 mitogen-activated protein kinase 9
MARCKS myristoylated alanine-rich protein kinase C substrate
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCAM melanoma cell adhesion molecule
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MITF microphthalmia-associated transcription factor
MSN moesin
MYL12B myosin, light chain 12B, regulatory
NF2 neurofibromin 2 (merlin)
NME1 NME/NM23 nucleoside diphosphate kinase 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PBK PDZ binding kinase
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1
POU3F2 POU class 3 homeobox 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R13L protein phosphatase 1, regulatory subunit 13 like
PRDX1 peroxiredoxin 1
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCA protein kinase C, alpha
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PTEN phosphatase and tensin homolog
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PXN paxillin
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SGK1 serum/glucocorticoid regulated kinase 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPRED2 sprouty-related, EVH1 domain containing 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STK11 serine/threonine kinase 11
TBX2 T-box 2
TERT telomerase reverse transcriptase
TNS3 tensin 3
TP53 tumor protein p53
TRIM28 tripartite motif containing 28
TTK TTK protein kinase
TYR tyrosinase
USF1 upstream transcription factor 1