melanomas Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)|A malignant, usually aggressive tumor composed of atypical, neoplastic melanocytes. Most often, melanomas arise in the skin (cutaneous melanomas) and include the following histologic subtypes: superficial spreading melanoma, nodular melanoma, acral lentiginous melanoma, and lentigo maligna melanoma. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas may also arise in other anatomic sites including the gastrointestinal system, eye, urinary tract, and reproductive system. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain. (Experimental Factor Ontology, EFO_0000756)
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Genes

199 genes co-occuring with the biological term melanomas in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADGRG1 adhesion G protein-coupled receptor G1
AGER advanced glycosylation end product-specific receptor
AIM1 absent in melanoma 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
AMACR alpha-methylacyl-CoA racemase
APC adenomatous polyposis coli
APP amyloid beta (A4) precursor protein
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ATG5 autophagy related 5
AURKB aurora kinase B
AXL AXL receptor tyrosine kinase
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BECN1 beclin 1, autophagy related
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BMP7 bone morphogenetic protein 7
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRMS1 breast cancer metastasis suppressor 1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCND1 cyclin D1
CD274 CD274 molecule
CD34 CD34 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CDC7 cell division cycle 7
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH5 cadherin 5, type 2 (vascular endothelium)
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPF centromere protein F, 350/400kDa
CHRM3 cholinergic receptor, muscarinic 3
CRH corticotropin releasing hormone
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTSD cathepsin D
CTSK cathepsin K
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEK DEK proto-oncogene
DIAPH1 diaphanous-related formin 1
DSG2 desmoglein 2
EGFR epidermal growth factor receptor
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EZR ezrin
FASN fatty acid synthase
FGF2 fibroblast growth factor 2 (basic)
GAB2 GRB2-associated binding protein 2
GHRHR growth hormone releasing hormone receptor
GLI1 GLI family zinc finger 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI30 interferon, gamma-inducible protein 30
IGF1R insulin-like growth factor 1 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL18 interleukin 18
IL24 interleukin 24
IL27 interleukin 27
ING2 inhibitor of growth family, member 2
ITGAV integrin, alpha V
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIF20A kinesin family member 20A
KIR2DS4 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLK6 kallikrein-related peptidase 6
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LOX lysyl oxidase
MAGEA3 melanoma antigen family A3
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma
MAP2 microtubule-associated protein 2
MAPK1 mitogen-activated protein kinase 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
MDM4 MDM4, p53 regulator
MERTK MER proto-oncogene, tyrosine kinase
MET MET proto-oncogene, receptor tyrosine kinase
MGC16025 uncharacterized LOC85009
MGMT O-6-methylguanine-DNA methyltransferase
MIA melanoma inhibitory activity
MIR145 microRNA 145
MIR205 microRNA 205
MIR214 microRNA 214
MIR375 microRNA 375
MITF microphthalmia-associated transcription factor
MKI67 marker of proliferation Ki-67
MLANA melan-A
MLH1 mutL homolog 1
MME membrane metallo-endopeptidase
MMP9 matrix metallopeptidase 9
MSH2 mutS homolog 2
MTAP methylthioadenosine phosphorylase
MTSS1 metastasis suppressor 1
MYOD1 myogenic differentiation 1
NCR1 natural cytotoxicity triggering receptor 1
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NES nestin
NEU3 sialidase 3 (membrane sialidase)
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NF1 neurofibromin 1
NGFR nerve growth factor receptor
NOG noggin
NOS1 nitric oxide synthase 1 (neuronal)
NOV nephroblastoma overexpressed
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PARP1 poly (ADP-ribose) polymerase 1
PAX3 paired box 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIR pirin (iron-binding nuclear protein)
PLXNB1 plexin B1
PNPT1 polyribonucleotide nucleotidyltransferase 1
POMC proopiomelanocortin
POU3F2 POU class 3 homeobox 2
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PRDM2 PR domain containing 2, with ZNF domain
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PROM1 prominin 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBX1 ring-box 1, E3 ubiquitin protein ligase
RET ret proto-oncogene
ROR1 receptor tyrosine kinase-like orphan receptor 1
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPSA ribosomal protein SA
S100A1 S100 calcium binding protein A1
S100B S100 calcium binding protein B
S100P S100 calcium binding protein P
SAT2 spermidine/spermine N1-acetyltransferase family member 2
SETDB1 SET domain, bifurcated 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SHH sonic hedgehog
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC26A1 solute carrier family 26 (anion exchanger), member 1
SMAD2 SMAD family member 2
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOCS3 suppressor of cytokine signaling 3
SOX10 SRY (sex determining region Y)-box 10
SOX2 SRY (sex determining region Y)-box 2
SOX9 SRY (sex determining region Y)-box 9
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TACR1 tachykinin receptor 1
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TFPI2 tissue factor pathway inhibitor 2
TIMP3 TIMP metallopeptidase inhibitor 3
TLR3 toll-like receptor 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRPM1 transient receptor potential cation channel, subfamily M, member 1
TSGA10 testis specific, 10
TUBB3 tubulin, beta 3 class III
UBE2I ubiquitin-conjugating enzyme E2I
VCAN versican
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WEE1 WEE1 G2 checkpoint kinase
WT1 Wilms tumor 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein