melanosome Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells. (Gene Ontology, GO_0042470)
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Genes

171 proteins co-occuring with the melanosome cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
TYR tyrosinase 3.66701
TYRP1 tyrosinase-related protein 1 2.65592
PMEL premelanosome protein 2.61551
RAB27A RAB27A, member RAS oncogene family 2.25586
MLPH melanophilin 2.17419
DCT dopachrome tautomerase 2.04231
MYO5A myosin VA (heavy chain 12, myoxin) 1.95653
MLANA melan-A 1.79707
MITF microphthalmia-associated transcription factor 1.76885
HPS1 Hermansky-Pudlak syndrome 1 1.76109
OCA2 oculocutaneous albinism II 1.72494
HPS3 Hermansky-Pudlak syndrome 3 1.56902
GPR143 G protein-coupled receptor 143 1.54122
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 1.53839
RAB38 RAB38, member RAS oncogene family 1.48871
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 1.41699
HPS5 Hermansky-Pudlak syndrome 5 1.36692
HPS4 Hermansky-Pudlak syndrome 4 1.34447
GPNMB glycoprotein (transmembrane) nmb 1.31519
RAB32 RAB32, member RAS oncogene family 1.31412
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.28676
MYO7A myosin VIIA 1.26551
SLC45A2 solute carrier family 45, member 2 1.25601
HPS6 Hermansky-Pudlak syndrome 6 1.2539
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 1.25075
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.19983
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) 1.02979
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 1.01585
LYST lysosomal trafficking regulator 1.01337
SYTL2 synaptotagmin-like 2 0.985367
POMC proopiomelanocortin 0.984393
MREG melanoregulin 0.980501
ENO2 enolase 2 (gamma, neuronal) 0.945907
LAMP1 lysosomal-associated membrane protein 1 0.931716
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 0.919982
MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 0.88286
SYTL4 synaptotagmin-like 4 0.806606
SLC35D3 solute carrier family 35, member D3 0.801562
ASIP agouti signaling protein 0.801562
EDN3 endothelin 3 0.79927
PDGFRA platelet-derived growth factor receptor, alpha polypeptide 0.798353
RAB27B RAB27B, member RAS oncogene family 0.763617
CD63 CD63 molecule 0.75181
MYRIP myosin VIIA and Rab interacting protein 0.724365
CANX calnexin 0.717236
KITLG KIT ligand 0.696905
MNT MAX network transcriptional repressor 0.669858
RPH3A rabphilin 3A 0.661208
CD68 CD68 molecule 0.616709
BLOC1S4 biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino 0.613742
CD34 CD34 molecule 0.588456
TBC1D10A TBC1 domain family, member 10A 0.586361
TH tyrosine hydroxylase 0.584268
SYP synaptophysin 0.575078
SLC24A4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 0.574244
RAB21 RAB21, member RAS oncogene family 0.572994
DPH2 DPH2 homolog (S. cerevisiae) 0.562602
RABGGTA Rab geranylgeranyltransferase, alpha subunit 0.553905
FGF7 fibroblast growth factor 7 0.54194
IGLV9-49 immunoglobulin lambda variable 9-49 0.525522
KIF13A kinesin family member 13A 0.523885
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 0.521841
APOPT1 apoptogenic 1, mitochondrial 0.518573
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 0.481661
UBAC1 UBA domain containing 1 0.478038
DTNBP1 dystrobrevin binding protein 1 0.478038
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 0.471609
RAB17 RAB17, member RAS oncogene family 0.470807
POU3F2 POU class 3 homeobox 2 0.4676
KRT20 keratin 20, type I 0.465198
KRT14 keratin 14, type I 0.463198
RAB3A RAB3A, member RAS oncogene family 0.461199
TP53 tumor protein p53 0.459602
PAH phenylalanine hydroxylase 0.458404
XG Xg blood group 0.454418
NF1 neurofibromin 1 0.446862
HLA-A major histocompatibility complex, class I, A 0.444482
MSH4 mutS homolog 4 0.444085
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 0.443292
DCTN1 dynactin 1 0.435775
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.431041
NCAPG non-SMC condensin I complex, subunit G 0.427497
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 0.424353
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 0.419252
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 0.418077
THEM5 thioesterase superfamily member 5 0.416902
RILPL1 Rab interacting lysosomal protein-like 1 0.408309
RILP Rab interacting lysosomal protein 0.404415
KRT7 keratin 7, type II 0.401304
VAMP7 vesicle-associated membrane protein 7 0.395873
KLK7 kallikrein-related peptidase 7 0.392775
SLC35G5 solute carrier family 35, member G5 0.386979
RAB8A RAB8A, member RAS oncogene family 0.386593
SNAPIN SNAP-associated protein 0.385822
KRT5 keratin 5, type II 0.382354
PAX3 paired box 3 0.380429
PKDREJ polycystin (PKD) family receptor for egg jelly 0.37697
RAB36 RAB36, member RAS oncogene family 0.370067
CFH complement factor H 0.365477
BAGE2 B melanoma antigen family, member 2 0.35899
SHD Src homology 2 domain containing transforming protein D 0.35899
PMCH pro-melanin-concentrating hormone 0.349484
ACPP acid phosphatase, prostate 0.344556
B3GAT1 beta-1,3-glucuronyltransferase 1 0.342285
KIF25 kinesin family member 25 0.341151
EDNRB endothelin receptor type B 0.338128
NCAM1 neural cell adhesion molecule 1 0.327205
MAGEA3 melanoma antigen family A3 0.326829
TBC1D20 TBC1 domain family, member 20 0.318205
FOXN1 forkhead box N1 0.317082
ATP7A ATPase, Cu++ transporting, alpha polypeptide 0.316708
PRCC papillary renal cell carcinoma (translocation-associated) 0.315212
SLC25A29 solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 0.312971
RAB37 RAB37, member RAS oncogene family 0.307377
UNC13D unc-13 homolog D (C. elegans) 0.30626
MB myoglobin 0.285138
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 0.284401
TCTEX1D4 Tctex1 domain containing 4 0.281821
RAB33A RAB33A, member RAS oncogene family 0.279612
RILPL2 Rab interacting lysosomal protein-like 2 0.279612
GAK cyclin G associated kinase 0.278877
PAX6 paired box 6 0.277406
ATF1 activating transcription factor 1 0.275936
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae) 0.273734
MIR203A microRNA 203a 0.272633
LYZ lysozyme 0.2708
ZBTB14 zinc finger and BTB domain containing 14 0.268603
KTN1 kinectin 1 (kinesin receptor) 0.268237
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 0.266774
ANTXR1 anthrax toxin receptor 1 0.26385
RAB5A RAB5A, member RAS oncogene family 0.254017
SCRT1 scratch family zinc finger 1 0.248578
PLXNC1 plexin C1 0.245323
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.243519
GIPC1 GIPC PDZ domain containing family, member 1 0.237042
FURIN furin (paired basic amino acid cleaving enzyme) 0.234174
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) 0.232386
MCOLN3 mucolipin 3 0.230601
FGF2 fibroblast growth factor 2 (basic) 0.229176
LAMP2 lysosomal-associated membrane protein 2 0.227752
F8 coagulation factor VIII, procoagulant component 0.227041
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 0.222083
SHROOM2 shroom family member 2 0.219969
RAB20 RAB20, member RAS oncogene family 0.219265
IL2RG interleukin 2 receptor, gamma 0.216111
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.214017
GPR162 G protein-coupled receptor 162 0.209169
CTSD cathepsin D 0.200999
SCG5 secretogranin V 0.19733
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 0.195353
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 0.193719
TSC2 tuberous sclerosis 2 0.192423
CDC16 cell division cycle 16 0.189539
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.185777
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 0.184853
MYO10 myosin X 0.180045
CLTC clathrin, heavy chain (Hc) 0.175466
GSTO1 glutathione S-transferase omega 1 0.169604
RBSN rabenosyn, RAB effector 0.165
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 0.163641
SHROOM3 shroom family member 3 0.1632
TFEB transcription factor EB 0.162117
UXT ubiquitously-expressed, prefoldin-like chaperone 0.161905
FRY furry homolog (Drosophila) 0.161275
ILVBL ilvB (bacterial acetolactate synthase)-like 0.160053
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.159462
RAB31 RAB31, member RAS oncogene family 0.159462
RAB2A RAB2A, member RAS oncogene family 0.158315
HMGA2 high mobility group AT-hook 2 0.158129
GUSB glucuronidase, beta 0.157039
RAB1A RAB1A, member RAS oncogene family 0.156342