mephenesin-2342 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the mephenesin-2342 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA2C adrenoceptor alpha 2C
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
APCS amyloid P component, serum
ARID5A AT rich interactive domain 5A (MRF1-like)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP11A ATPase, class VI, type 11A
BCL2 B-cell CLL/lymphoma 2
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
C8ORF44 chromosome 8 open reading frame 44
C9ORF156 chromosome 9 open reading frame 156
CA9 carbonic anhydrase IX
CADM4 cell adhesion molecule 4
CBR3 carbonyl reductase 3
CD82 CD82 molecule
CDK20 cyclin-dependent kinase 20
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CFLAR CASP8 and FADD-like apoptosis regulator
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal)
CRTC1 CREB regulated transcription coactivator 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOCK5 dedicator of cytokinesis 5
ENO3 enolase 3 (beta, muscle)
FAM105A family with sequence similarity 105, member A
FAM63A family with sequence similarity 63, member A
FBXL18 F-box and leucine-rich repeat protein 18
FLJ11292
FOXO4 forkhead box O4
FRS3 fibroblast growth factor receptor substrate 3
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GPNMB glycoprotein (transmembrane) nmb
GPR153 G protein-coupled receptor 153
GRB7 growth factor receptor-bound protein 7
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HABP2 hyaluronan binding protein 2
HDAC6 histone deacetylase 6
HIPK2 homeodomain interacting protein kinase 2
HOXB6 homeobox B6
HRH1 histamine receptor H1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IER3 immediate early response 3
IGF1 insulin-like growth factor 1 (somatomedin C)
INO80D INO80 complex subunit D
ITGA8 integrin, alpha 8
KCTD13 potassium channel tetramerization domain containing 13
KIF1B kinesin family member 1B
KLHL36 kelch-like family member 36
KRT6B keratin 6B, type II
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
LIMD2 LIM domain containing 2
LOX lysyl oxidase
LTB lymphotoxin beta (TNF superfamily, member 3)
LTB4R leukotriene B4 receptor
MAST2 microtubule associated serine/threonine kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
MINK1 misshapen-like kinase 1
MMP25 matrix metallopeptidase 25
MOG myelin oligodendrocyte glycoprotein
NCOA3 nuclear receptor coactivator 3
NDRG2 NDRG family member 2
NECAB3 N-terminal EF-hand calcium binding protein 3
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR4A1 nuclear receptor subfamily 4, group A, member 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NXF2 nuclear RNA export factor 2
PDE12 phosphodiesterase 12
PDE4DIP phosphodiesterase 4D interacting protein
PHF7 PHD finger protein 7
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PLK4 polo-like kinase 4
POPDC3 popeye domain containing 3
PRDM14 PR domain containing 14
PVR poliovirus receptor
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RHOBTB3 Rho-related BTB domain containing 3
RNF19B ring finger protein 19B
RPL35A ribosomal protein L35a
SCAND2P SCAN domain containing 2 pseudogene
SIDT2 SID1 transmembrane family, member 2
SIX2 SIX homeobox 2
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPRED2 sprouty-related, EVH1 domain containing 2
SRPX2 sushi-repeat containing protein, X-linked 2
STXBP5L syntaxin binding protein 5-like
TBCD tubulin folding cofactor D
TBKBP1 TBK1 binding protein 1
TEX261 testis expressed 261
TMEM242 transmembrane protein 242
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPMT thiopurine S-methyltransferase
TRIM45 tripartite motif containing 45
TTC23 tetratricopeptide repeat domain 23
TTLL1 tubulin tyrosine ligase-like family member 1
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
USP2 ubiquitin specific peptidase 2
VNN1 vanin 1

decreased expression

Symbol Name
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5
ADAP2 ArfGAP with dual PH domains 2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AHDC1 AT hook, DNA binding motif, containing 1
AHR aryl hydrocarbon receptor
ASAP1-IT1 ASAP1 intronic transcript 1
ASB8 ankyrin repeat and SOCS box containing 8
BACE1 beta-site APP-cleaving enzyme 1
BAHCC1 BAH domain and coiled-coil containing 1
C11ORF71 chromosome 11 open reading frame 71
C16ORF59 chromosome 16 open reading frame 59
C17ORF75 chromosome 17 open reading frame 75
C6ORF47 chromosome 6 open reading frame 47
C7ORF69 chromosome 7 open reading frame 69
CENPB centromere protein B, 80kDa
CSF1R colony stimulating factor 1 receptor
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DDN dendrin
DHRS11 dehydrogenase/reductase (SDR family) member 11
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSPP dentin sialophosphoprotein
EGLN2 egl-9 family hypoxia-inducible factor 2
ELP6 elongator acetyltransferase complex subunit 6
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FADS2 fatty acid desaturase 2
FBXL14 F-box and leucine-rich repeat protein 14
FKBPL FK506 binding protein like
GAB2 GRB2-associated binding protein 2
HDAC5 histone deacetylase 5
HIST1H2AI histone cluster 1, H2ai
HIST2H2BE histone cluster 2, H2be
HMGB3P1 high mobility group box 3 pseudogene 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOOK2 hook microtubule-tethering protein 2
HS1BP3 HCLS1 binding protein 3
INPPL1 inositol polyphosphate phosphatase-like 1
IRF2 interferon regulatory factor 2
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KAT2A K(lysine) acetyltransferase 2A
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LAX1 lymphocyte transmembrane adaptor 1
LINS lines homolog (Drosophila)
LRRC37A2 leucine rich repeat containing 37, member A2
MAGEB2 melanoma antigen family B2
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3
MLPH melanophilin
MRPL44 mitochondrial ribosomal protein L44
NAG18 NAG18 mRNA
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma
NAT6 N-acetyltransferase 6 (GCN5-related)
NCS1 neuronal calcium sensor 1
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NHEJ1 nonhomologous end-joining factor 1
NOD1 nucleotide-binding oligomerization domain containing 1
NTSR1 neurotensin receptor 1 (high affinity)
OTUD3 OTU deubiquitinase 3
PMCH pro-melanin-concentrating hormone
PROSER1 proline and serine rich 1
PTGES2 prostaglandin E synthase 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCAN3 RCAN family member 3
RFXAP regulatory factor X-associated protein
RNF144A ring finger protein 144A
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF2 ring finger protein 2
RPE ribulose-5-phosphate-3-epimerase
SCAMP3 secretory carrier membrane protein 3
SCYL2 SCY1-like 2 (S. cerevisiae)
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SETD1A SET domain containing 1A
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMA4 glucuronidase, beta pseudogene
SMR3A submaxillary gland androgen regulated protein 3A
SOHLH2 spermatogenesis and oogenesis specific basic helix-loop-helix 2
SP140L SP140 nuclear body protein-like
SPATA2L spermatogenesis associated 2-like
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STAR steroidogenic acute regulatory protein
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TKFC triokinase/FMN cyclase
TLR4 toll-like receptor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN13 tetraspanin 13
TSPAN14 tetraspanin 14
TSPAN5 tetraspanin 5
TTPAL tocopherol (alpha) transfer protein-like
TUBGCP5 tubulin, gamma complex associated protein 5
USP11 ubiquitin specific peptidase 11
WDR5B WD repeat domain 5B
WWC3 WWC family member 3
ZAK sterile alpha motif and leucine zipper containing kinase AZK
ZBTB48 zinc finger and BTB domain containing 48
ZDHHC18 zinc finger, DHHC-type containing 18
ZNF143 zinc finger protein 143
ZNF302 zinc finger protein 302