merck-ketone Gene Set
Genes
49 genes differentially expressed following the merck-ketone small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.
increased expression
| Symbol |
Name |
Standardized Value |
|
ALDOC
|
aldolase C, fructose-bisphosphate
|
6.13866
|
|
STXBP1
|
syntaxin binding protein 1
|
4.40828
|
|
NPC1
|
Niemann-Pick disease, type C1
|
4.27173
|
|
PLA2G15
|
phospholipase A2, group XV
|
4.09737
|
|
PBXIP1
|
pre-B-cell leukemia homeobox interacting protein 1
|
3.90876
|
|
CDKN1C
|
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
|
3.68339
|
|
CTSA
|
cathepsin A
|
3.68202
|
|
ABCA7
|
ATP-binding cassette, sub-family A (ABC1), member 7
|
3.64278
|
|
GCDH
|
glutaryl-CoA dehydrogenase
|
3.61808
|
|
RAD9A
|
RAD9 homolog A (S. pombe)
|
3.56596
|
|
GLRX
|
glutaredoxin (thioltransferase)
|
3.55033
|
|
CORO1A
|
coronin, actin binding protein, 1A
|
3.54706
|
|
CCND3
|
cyclin D3
|
3.53084
|
|
CLEC16A
|
C-type lectin domain family 16, member A
|
3.43707
|
|
ATG2A
|
autophagy related 2A
|
3.38947
|
|
PDE6D
|
phosphodiesterase 6D, cGMP-specific, rod, delta
|
3.3191
|
|
MT1X
|
metallothionein 1X
|
3.2889
|
|
AAMDC
|
adipogenesis associated, Mth938 domain containing
|
3.27311
|
|
NECAP2
|
NECAP endocytosis associated 2
|
3.21638
|
|
FADS3
|
fatty acid desaturase 3
|
3.19915
|
|
LPIN1
|
lipin 1
|
3.17495
|
|
LRCH4
|
leucine-rich repeats and calponin homology (CH) domain containing 4
|
3.14764
|
|
PRKCD
|
protein kinase C, delta
|
3.13726
|
|
FOXO4
|
forkhead box O4
|
3.13375
|
|
TNFSF9
|
tumor necrosis factor (ligand) superfamily, member 9
|
3.13298
|
|
MT2A
|
metallothionein 2A
|
3.09022
|
|
ROGDI
|
rogdi homolog (Drosophila)
|
3.06566
|
|
GADD45B
|
growth arrest and DNA-damage-inducible, beta
|
3.00669
|
|
RAB29
|
RAB29, member RAS oncogene family
|
3.00383
|
decreased expression
| Symbol |
Name |
Standardized Value |
|
SUV39H1
|
suppressor of variegation 3-9 homolog 1 (Drosophila)
|
-5.23014
|
|
PLK1
|
polo-like kinase 1
|
-3.8529
|
|
KEAP1
|
kelch-like ECH-associated protein 1
|
-3.68039
|
|
PMF1
|
polyamine-modulated factor 1
|
-3.5239
|
|
GABPB1
|
GA binding protein transcription factor, beta subunit 1
|
-3.29684
|
|
ANP32B
|
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
|
-3.16894
|
|
TLK1
|
tousled-like kinase 1
|
-3.12954
|
|
TLCD3A
|
TLC domain containing 3A
|
-3.11879
|
|
NRIP1
|
nuclear receptor interacting protein 1
|
-3.10964
|
|
KRT84
|
keratin 84, type II
|
-3.10177
|
|
RBMX
|
RNA binding motif protein, X-linked
|
-3.09811
|
|
NSMAF
|
neutral sphingomyelinase (N-SMase) activation associated factor
|
-3.09218
|
|
GTSE1
|
G-2 and S-phase expressed 1
|
-3.08841
|
|
AKAP8
|
A kinase (PRKA) anchor protein 8
|
-3.08702
|
|
CENPN
|
centromere protein N
|
-3.08045
|
|
NBN
|
nibrin
|
-3.04493
|
|
PARP2
|
poly (ADP-ribose) polymerase 2
|
-3.03938
|
|
ST7
|
suppression of tumorigenicity 7
|
-3.03557
|
|
SENP6
|
SUMO1/sentrin specific peptidase 6
|
-3.02846
|
|
INTS14
|
integrator complex subunit 14
|
-3.00834
|
