mesalazine-124 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the mesalazine-124 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
ALDOB aldolase B, fructose-bisphosphate
ALPK1 alpha-kinase 1
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASIC4 acid sensing (proton gated) ion channel family member 4
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BAIAP3 BAI1-associated protein 3
BBC3 BCL2 binding component 3
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C1QL1 complement component 1, q subcomponent-like 1
CAV3 caveolin 3
CCDC40 coiled-coil domain containing 40
CCDC71 coiled-coil domain containing 71
CEP250 centrosomal protein 250kDa
CLCN7 chloride channel, voltage-sensitive 7
CLTA clathrin, light chain A
CNGB3 cyclic nucleotide gated channel beta 3
COX5B cytochrome c oxidase subunit Vb
CRTC1 CREB regulated transcription coactivator 1
CTNS cystinosin, lysosomal cystine transporter
CTTN cortactin
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal
DGCR2 DiGeorge syndrome critical region gene 2
DMPK dystrophia myotonica-protein kinase
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DRD2 dopamine receptor D2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EFCAB14 EF-hand calcium binding domain 14
EFNB3 ephrin-B3
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPS8L1 EPS8-like 1
FLT3 fms-related tyrosine kinase 3
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GRWD1 glutamate-rich WD repeat containing 1
GSK3A glycogen synthase kinase 3 alpha
HDLBP high density lipoprotein binding protein
HIST1H2BI histone cluster 1, H2bi
HIST2H2AA3 histone cluster 2, H2aa3
HLA-G major histocompatibility complex, class I, G
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LUZP1 leucine zipper protein 1
LY6G6C lymphocyte antigen 6 complex, locus G6C
MAP4 microtubule-associated protein 4
MCAM melanoma cell adhesion molecule
METTL7A methyltransferase like 7A
MPPE1 metallophosphoesterase 1
MRPL41 mitochondrial ribosomal protein L41
MT1HL1 metallothionein 1H-like 1
MT3 metallothionein 3
MYL10 myosin, light chain 10, regulatory
MYO9B myosin IXB
NIPAL2 NIPA-like domain containing 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUP214 nucleoporin 214kDa
OGFR opioid growth factor receptor
PDCD6 programmed cell death 6
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLSCR3 phospholipid scramblase 3
PRB1 proline-rich protein BstNI subfamily 1
PRELP proline/arginine-rich end leucine-rich repeat protein
PTBP3 polypyrimidine tract binding protein 3
QTRT1 queuine tRNA-ribosyltransferase 1
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBMX2 RNA binding motif protein, X-linked 2
RHO rhodopsin
RMND5B required for meiotic nuclear division 5 homolog B (S. cerevisiae)
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RPL14 ribosomal protein L14
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SEZ6L seizure related 6 homolog (mouse)-like
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC41A3 solute carrier family 41, member 3
SMO smoothened, frizzled class receptor
SOCS3 suppressor of cytokine signaling 3
SOX4 SRY (sex determining region Y)-box 4
SQSTM1 sequestosome 1
SRP72 signal recognition particle 72kDa
SZRD1 SUZ RNA binding domain containing 1
T T, brachyury homolog (mouse)
TMPRSS11D transmembrane protease, serine 11D
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOE1 target of EGR1, member 1 (nuclear)
TPMT thiopurine S-methyltransferase
TREX1 three prime repair exonuclease 1
TRIM38 tripartite motif containing 38
ZNF609 zinc finger protein 609
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
AACS acetoacetyl-CoA synthetase
ADSS adenylosuccinate synthase
ARHGAP10 Rho GTPase activating protein 10
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ATG14 autophagy related 14
AUH AU RNA binding protein/enoyl-CoA hydratase
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BIRC2 baculoviral IAP repeat containing 2
BLMH bleomycin hydrolase
BRD7 bromodomain containing 7
C16ORF62 chromosome 16 open reading frame 62
C1ORF112 chromosome 1 open reading frame 112
C4ORF27 chromosome 4 open reading frame 27
C8ORF33 chromosome 8 open reading frame 33
CAB39 calcium binding protein 39
CAPN7 calpain 7
CBR1 carbonyl reductase 1
CD320 CD320 molecule
CD48 CD48 molecule
CDK5RAP1 CDK5 regulatory subunit associated protein 1
CGRRF1 cell growth regulator with ring finger domain 1
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHD1 chromodomain helicase DNA binding protein 1
CKAP2 cytoskeleton associated protein 2
CLK4 CDC-like kinase 4
COL4A5 collagen, type IV, alpha 5
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUTC cutC copper transporter
CYTH2 cytohesin 2
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DPYSL2 dihydropyrimidinase-like 2
ERBB2IP erbb2 interacting protein
FOXC1 forkhead box C1
FTO fat mass and obesity associated
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GDF3 growth differentiation factor 3
GOLM1 golgi membrane protein 1
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GRAMD4 GRAM domain containing 4
H1F0 H1 histone family, member 0
HAT1 histone acetyltransferase 1
HDAC7 histone deacetylase 7
HELLS helicase, lymphoid-specific
HOXB2 homeobox B2
HPS5 Hermansky-Pudlak syndrome 5
HTATSF1 HIV-1 Tat specific factor 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL15RA interleukin 15 receptor, alpha
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KAT7 K(lysine) acetyltransferase 7
KIF11 kinesin family member 11
LMNB1 lamin B1
MAPK3 mitogen-activated protein kinase 3
MOAP1 modulator of apoptosis 1
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NDRG4 NDRG family member 4
NSD1 nuclear receptor binding SET domain protein 1
OIP5 Opa interacting protein 5
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PERP PERP, TP53 apoptosis effector
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PLK1 polo-like kinase 1
PLXNB3 plexin B3
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPOX protoporphyrinogen oxidase
PRCP prolylcarboxypeptidase (angiotensinase C)
PRPH peripherin
RANBP17 RAN binding protein 17
RANBP6 RAN binding protein 6
RMDN1 regulator of microtubule dynamics 1
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
SH2D4A SH2 domain containing 4A
SHPK sedoheptulokinase
SIL1 SIL1 nucleotide exchange factor
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SNX17 sorting nexin 17
SNX6 sorting nexin 6
SPDL1 spindle apparatus coiled-coil protein 1
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit
SUSD6 sushi domain containing 6
TBPL1 TBP-like 1
TET3 tet methylcytosine dioxygenase 3
TGFB3 transforming growth factor, beta 3
TMEM123 transmembrane protein 123
TOP2B topoisomerase (DNA) II beta 180kDa
TSC22D1 TSC22 domain family, member 1
TTI1 TELO2 interacting protein 1
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USP39 ubiquitin specific peptidase 39
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
YIPF5 Yip1 domain family, member 5
ZNF217 zinc finger protein 217
ZNF430 zinc finger protein 430