mesalazine-7241 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the mesalazine-7241 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGMAT agmatine ureohydrolase (agmatinase)
ALDOB aldolase B, fructose-bisphosphate
AMH anti-Mullerian hormone
AMPH amphiphysin
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARRB1 arrestin, beta 1
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C2ORF68 chromosome 2 open reading frame 68
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL13 chemokine (C-C motif) ligand 13
CCL19 chemokine (C-C motif) ligand 19
CD82 CD82 molecule
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1
CRIP1 cysteine-rich protein 1 (intestinal)
CRTC1 CREB regulated transcription coactivator 1
CUL4B cullin 4B
CXCR4 chemokine (C-X-C motif) receptor 4
DLC1 DLC1 Rho GTPase activating protein
DOK4 docking protein 4
DXO decapping exoribonuclease
EGFL7 EGF-like-domain, multiple 7
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAMT guanidinoacetate N-methyltransferase
GJA8 gap junction protein, alpha 8, 50kDa
GJB3 gap junction protein, beta 3, 31kDa
GLI3 GLI family zinc finger 3
GLRX glutaredoxin (thioltransferase)
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRM8 glutamate receptor, metabotropic 8
HAPLN1 hyaluronan and proteoglycan link protein 1
HAUS5 HAUS augmin-like complex, subunit 5
HIST1H2BM histone cluster 1, H2bm
HIST1H4D histone cluster 1, H4d
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNMT histamine N-methyltransferase
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSPG2 heparan sulfate proteoglycan 2
IRS2 insulin receptor substrate 2
KAT8 K(lysine) acetyltransferase 8
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIR2DL3 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3
KITLG KIT ligand
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LRRC41 leucine rich repeat containing 41
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPK14 mitogen-activated protein kinase 14
MITF microphthalmia-associated transcription factor
MOGAT2 monoacylglycerol O-acyltransferase 2
MVP major vault protein
MX2 MX dynamin-like GTPase 2
NCKIPSD NCK interacting protein with SH3 domain
NDOR1 NADPH dependent diflavin oxidoreductase 1
NDRG2 NDRG family member 2
NEK3 NIMA-related kinase 3
NOL12 nucleolar protein 12
NRP2 neuropilin 2
NYX nyctalopin
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PEX3 peroxisomal biogenesis factor 3
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLK4 polo-like kinase 4
PMEL premelanosome protein
PRKDC protein kinase, DNA-activated, catalytic polypeptide
RAB6B RAB6B, member RAS oncogene family
RARG retinoic acid receptor, gamma
RERE arginine-glutamic acid dipeptide (RE) repeats
SCAPER S-phase cyclin A-associated protein in the ER
SETD8 SET domain containing (lysine methyltransferase) 8
SIGLEC6 sialic acid binding Ig-like lectin 6
SIK2 salt-inducible kinase 2
SLC22A14 solute carrier family 22, member 14
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC44A1 solute carrier family 44 (choline transporter), member 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPRR2B small proline-rich protein 2B
SRSF5 serine/arginine-rich splicing factor 5
SSPN sarcospan
SYBU syntabulin (syntaxin-interacting)
TAT tyrosine aminotransferase
TRD T cell receptor delta locus
TRIM29 tripartite motif containing 29
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TTC28 tetratricopeptide repeat domain 28
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
WDR78 WD repeat domain 78
WDTC1 WD and tetratricopeptide repeats 1
ZNF324 zinc finger protein 324
ZNF362 zinc finger protein 362
ZNF442 zinc finger protein 442
ZNF444 zinc finger protein 444
ZNF614 zinc finger protein 614
ZSCAN12 zinc finger and SCAN domain containing 12

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ADGRE5 adhesion G protein-coupled receptor E5
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARL15 ADP-ribosylation factor-like 15
ASB9 ankyrin repeat and SOCS box containing 9
ATAD3A ATPase family, AAA domain containing 3A
AXIN1 axin 1
BAHD1 bromo adjacent homology domain containing 1
BBC3 BCL2 binding component 3
BRAF B-Raf proto-oncogene, serine/threonine kinase
CCNO cyclin O
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CDK20 cyclin-dependent kinase 20
CDON cell adhesion associated, oncogene regulated
CEP162 centrosomal protein 162kDa
CORO2A coronin, actin binding protein, 2A
CTDNEP1 CTD nuclear envelope phosphatase 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCAF13 DDB1 and CUL4 associated factor 13
DCAF17 DDB1 and CUL4 associated factor 17
DENND4A DENN/MADD domain containing 4A
ENO2 enolase 2 (gamma, neuronal)
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPB41L5 erythrocyte membrane protein band 4.1 like 5
F3 coagulation factor III (thromboplastin, tissue factor)
FA2H fatty acid 2-hydroxylase
FAM63A family with sequence similarity 63, member A
FAM86C1 family with sequence similarity 86, member C1
FER fer (fps/fes related) tyrosine kinase
FGGY FGGY carbohydrate kinase domain containing
FHOD1 formin homology 2 domain containing 1
GAA glucosidase, alpha; acid
GFOD2 glucose-fructose oxidoreductase domain containing 2
GLCE glucuronic acid epimerase
GSTA4 glutathione S-transferase alpha 4
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
GUSBP3 glucuronidase, beta pseudogene 3
IL4R interleukin 4 receptor
IRF2BP1 interferon regulatory factor 2 binding protein 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KIF13B kinesin family member 13B
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LRP3 low density lipoprotein receptor-related protein 3
LYPD1 LY6/PLAUR domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MED15 mediator complex subunit 15
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MRPL44 mitochondrial ribosomal protein L44
MRPL52 mitochondrial ribosomal protein L52
MSL2 male-specific lethal 2 homolog (Drosophila)
MYO1E myosin IE
NABP2 nucleic acid binding protein 2
NAV2 neuron navigator 2
NEK11 NIMA-related kinase 11
NRSN2 neurensin 2
PAQR4 progestin and adipoQ receptor family member IV
PCDHGB5 protocadherin gamma subfamily B, 5
PDE12 phosphodiesterase 12
PDK1 pyruvate dehydrogenase kinase, isozyme 1
POLH polymerase (DNA directed), eta
PRICKLE3 prickle homolog 3 (Drosophila)
RAB33B RAB33B, member RAS oncogene family
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RPL23AP32 ribosomal protein L23a pseudogene 32
RPRD2 regulation of nuclear pre-mRNA domain containing 2
SCD5 stearoyl-CoA desaturase 5
SIPA1 signal-induced proliferation-associated 1
SIRAL2 SIR2 antiphage like 2
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOX12 SRY (sex determining region Y)-box 12
SREK1IP1 SREK1-interacting protein 1
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TIGD6 tigger transposable element derived 6
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TTC33 tetratricopeptide repeat domain 33
UBXN6 UBX domain protein 6
VASH2 vasohibin 2
VAX2 ventral anterior homeobox 2
WDR91 WD repeat domain 91
XYLT2 xylosyltransferase II
ZBTB6 zinc finger and BTB domain containing 6
ZDHHC24 zinc finger, DHHC-type containing 24
ZMAT5 zinc finger, matrin-type 5
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF248 zinc finger protein 248
ZNF573 zinc finger protein 573
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669
ZNF721 zinc finger protein 721
ZNHIT2 zinc finger, HIT-type containing 2