metabolic syndrome Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_14221)
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Genes

159 genes associated with the disease metabolic syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8
ACACB acetyl-CoA carboxylase beta
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACE angiotensin I converting enzyme
ADA adenosine deaminase
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary)
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIPOR1 adiponectin receptor 1
ADIPOR2 adiponectin receptor 2
ADRB2 adrenoceptor beta 2, surface
ADRB3 adrenoceptor beta 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AGTR2 angiotensin II receptor, type 2
AHSG alpha-2-HS-glycoprotein
AKAP10 A kinase (PRKA) anchor protein 10
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMPD1 adenosine monophosphate deaminase 1
ANGPTL6 angiopoietin-like 6
ANXA5 annexin A5
APOA4 apolipoprotein A-IV
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOC3 apolipoprotein C-III
APOE apolipoprotein E
AR androgen receptor
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
BCHE butyrylcholinesterase
C3 complement component 3
CCL11 chemokine (C-C motif) ligand 11
CCL2 chemokine (C-C motif) ligand 2
CD40LG CD40 ligand
CETP cholesteryl ester transfer protein, plasma
CLOCK clock circadian regulator
COL3A1 collagen, type III, alpha 1
CPB2 carboxypeptidase B2 (plasma)
CRY2 cryptochrome circadian clock 2
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CSH2 chorionic somatomammotropin hormone 2
CTSG cathepsin G
CX3CR1 chemokine (C-X3-C motif) receptor 1
DRD2 dopamine receptor D2
EDN1 endothelin 1
ELN elastin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
F3 coagulation factor III (thromboplastin, tissue factor)
FAAH fatty acid amide hydrolase
FABP1 fatty acid binding protein 1, liver
FABP2 fatty acid binding protein 2, intestinal
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGB fibrinogen beta chain
FNTA farnesyltransferase, CAAX box, alpha
FNTB farnesyltransferase, CAAX box, beta
FOXC2 forkhead box C2
FTO fat mass and obesity associated
GCLM glutamate-cysteine ligase, modifier subunit
GH2 growth hormone 2
GHR growth hormone receptor
GHRL ghrelin/obestatin prepropeptide
GHSR growth hormone secretagogue receptor
GJA4 gap junction protein, alpha 4, 37kDa
GLO1 glyoxalase I
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GPX1 glutathione peroxidase 1
HMOX1 heme oxygenase 1
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
IDE insulin-degrading enzyme
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IGFBP1 insulin-like growth factor binding protein 1
IL10 interleukin 10
IL15 interleukin 15
IL15RA interleukin 15 receptor, alpha
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IRS1 insulin receptor substrate 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11
LCT lactase
LDLR low density lipoprotein receptor
LEP leptin
LEPR leptin receptor
LGALS2 lectin, galactoside-binding, soluble, 2
LIMK1 LIM domain kinase 1
LIPC lipase, hepatic
LMNA lamin A/C
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LTA lymphotoxin alpha
LTA4H leukotriene A4 hydrolase
MKKS McKusick-Kaufman syndrome
MMP1 matrix metallopeptidase 1
MMP12 matrix metallopeptidase 12
MMP3 matrix metallopeptidase 3
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
NCOA3 nuclear receptor coactivator 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NPAS2 neuronal PAS domain protein 2
NPY neuropeptide Y
OPN4 opsin 4
OR13G1 olfactory receptor, family 13, subfamily G, member 1
P2RY12 purinergic receptor P2Y, G-protein coupled, 12
PALLD palladin, cytoskeletal associated protein
PARL presenilin associated, rhomboid-like
PAX4 paired box 4
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE4D phosphodiesterase 4D, cAMP-specific
PDX1 pancreatic and duodenal homeobox 1
PDZK1 PDZ domain containing 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PER2 period circadian clock 2
PLCB4 phospholipase C, beta 4
PLIN1 perilipin 1
PON1 paraoxonase 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPP1R3A protein phosphatase 1, regulatory subunit 3A
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RETN resistin
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase
SELE selectin E
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS2 thrombospondin 2
TIMELESS timeless circadian clock
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRIB3 tribbles pseudokinase 3
UBL5 ubiquitin-like 5
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UCP3 uncoupling protein 3 (mitochondrial, proton carrier)
USF1 upstream transcription factor 1
UTS2 urotensin 2
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VIPR2 vasoactive intestinal peptide receptor 2
VKORC1 vitamin K epoxide reductase complex, subunit 1
WFS1 Wolfram syndrome 1 (wolframin)
WRN Werner syndrome, RecQ helicase-like
ZMPSTE24 zinc metallopeptidase STE24