metachromatic leukodystrophy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system. (Human Disease Ontology, DOID_10581)
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Genes

47 genes co-occuring with the disease metachromatic leukodystrophy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
ARSA arylsulfatase A 4.14228
ARSH arylsulfatase family, member H 2.3453
ARSD arylsulfatase D 1.81555
PSAP prosaposin 1.77406
ARSE arylsulfatase E (chondrodysplasia punctata 1) 1.68816
ARSB arylsulfatase B 1.60502
SUMF1 sulfatase modifying factor 1 1.44123
GALC galactosylceramidase 1.34199
GAL3ST1 galactose-3-O-sulfotransferase 1 1.19834
HEXA hexosaminidase A (alpha polypeptide) 1.18582
GLB1 galactosidase, beta 1 1.12656
STS steroid sulfatase (microsomal), isozyme S 1.11351
MAP9 microtubule-associated protein 9 1.09251
SGSH N-sulfoglucosamine sulfohydrolase 1.08999
M6PR mannose-6-phosphate receptor (cation dependent) 1.0816
MAL mal, T-cell differentiation protein 1.04251
IDS iduronate 2-sulfatase 0.927932
MAN1B1 mannosidase, alpha, class 1B, member 1 0.890898
SKAP2 src kinase associated phosphoprotein 2 0.870006
TMLHE trimethyllysine hydroxylase, epsilon 0.863046
GAA glucosidase, alpha; acid 0.793771
PXT1 peroxisomal, testis specific 1 0.596792
ACP2 acid phosphatase 2, lysosomal 0.486266
GBA glucosidase, beta, acid 0.472982
IGF2R insulin-like growth factor 2 receptor 0.470332
SHD Src homology 2 domain containing transforming protein D 0.468441
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.462394
ENGASE endo-beta-N-acetylglucosaminidase 0.456355
POU3F4 POU class 3 homeobox 4 0.455601
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 0.446182
HOXB4 homeobox B4 0.43227
MBP myelin basic protein 0.421765
CUTA cutA divalent cation tolerance homolog (E. coli) 0.393374
HEXB hexosaminidase B (beta polypeptide) 0.391513
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.387794
GM2A GM2 ganglioside activator 0.384451
S1PR3 sphingosine-1-phosphate receptor 3 0.366301
GNS glucosamine (N-acetyl)-6-sulfatase 0.329565
MAG myelin associated glycoprotein 0.324094
KIF11 kinesin family member 11 0.318635
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 0.313552
TYROBP TYRO protein tyrosine kinase binding protein 0.298731
AGA aspartylglucosaminidase 0.277227
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.263368
SNCB synuclein, beta 0.246098
LMNB1 lamin B1 0.186811
GALNS galactosamine (N-acetyl)-6-sulfatase 0.18621