metalloendopeptidase activity Gene Set

Dataset GO Molecular Function Annotations 2025
Category structural or functional annotations
Type molecular function
Description Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. (Gene Ontology, GO_0004222)
External Link http://amigo.geneontology.org/amigo/term/GO:0004222
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Genes

100 genes performing the metalloendopeptidase activity molecular function from the curated GO Molecular Function Annotations 2025 dataset.

Symbol Name
ACE angiotensin I converting enzyme
ADAM10 ADAM metallopeptidase domain 10
ADAM11 ADAM metallopeptidase domain 11
ADAM12 ADAM metallopeptidase domain 12
ADAM15 ADAM metallopeptidase domain 15
ADAM17 ADAM metallopeptidase domain 17
ADAM18 ADAM metallopeptidase domain 18
ADAM19 ADAM metallopeptidase domain 19
ADAM2 ADAM metallopeptidase domain 2
ADAM20 ADAM metallopeptidase domain 20
ADAM21 ADAM metallopeptidase domain 21
ADAM22 ADAM metallopeptidase domain 22
ADAM23 ADAM metallopeptidase domain 23
ADAM28 ADAM metallopeptidase domain 28
ADAM29 ADAM metallopeptidase domain 29
ADAM30 ADAM metallopeptidase domain 30
ADAM32 ADAM metallopeptidase domain 32
ADAM33 ADAM metallopeptidase domain 33
ADAM7 ADAM metallopeptidase domain 7
ADAM8 ADAM metallopeptidase domain 8
ADAM9 ADAM metallopeptidase domain 9
ADAMDEC1 ADAM-like, decysin 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9
ADAMTSL2 ADAMTS-like 2
AFG3L2 AFG3-like AAA ATPase 2
ASTL astacin-like metallo-endopeptidase (M12 family)
BMP1 bone morphogenetic protein 1
CLCA1 chloride channel accessory 1
CLCA2 chloride channel accessory 2
CLCA4 chloride channel accessory 4
ECE1 endothelin converting enzyme 1
ECEL1 endothelin converting enzyme-like 1
EEF1AKMT4-ECE2 EEF1AKMT4-ECE2 readthrough
IDE insulin-degrading enzyme
KEL Kell blood group, metallo-endopeptidase
KLK6 kallikrein-related peptidase 6
MBTPS2 membrane-bound transcription factor peptidase, site 2
MEP1A meprin A, alpha (PABA peptide hydrolase)
MEP1B meprin A, beta
MIPEP mitochondrial intermediate peptidase
MMEL1 membrane metallo-endopeptidase-like 1
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP19 matrix metallopeptidase 19
MMP2 matrix metallopeptidase 2
MMP21 matrix metallopeptidase 21
MMP23B matrix metallopeptidase 23B
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MMP25 matrix metallopeptidase 25
MMP26 matrix metallopeptidase 26
MMP27 matrix metallopeptidase 27
MMP28 matrix metallopeptidase 28
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
NLN neurolysin (metallopeptidase M3 family)
NRDC nardilysin convertase
OMA1 OMA1 zinc metallopeptidase
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PAPPA2 pappalysin 2
PHEX phosphate regulating endopeptidase homolog, X-linked
PITRM1 pitrilysin metallopeptidase 1
PMPCB peptidase (mitochondrial processing) beta
PRSS2 protease, serine, 2 (trypsin 2)
RCE1 Ras converting CAAX endopeptidase 1
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive)
SPRTN SprT-like N-terminal domain
THOP1 thimet oligopeptidase 1
TLL1 tolloid-like 1
TLL2 tolloid-like 2
TMPRSS6 transmembrane protease, serine 6
TRABD2A TraB domain containing 2A
TRABD2B TraB domain containing 2B
ZMPSTE24 zinc metallopeptidase STE24