metanephrine-6734 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the metanephrine-6734 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOXL acyl-CoA oxidase-like
ADAP1 ArfGAP with dual PH domains 1
ADCY9 adenylate cyclase 9
ADGRE2 adhesion G protein-coupled receptor E2
ADRB1 adrenoceptor beta 1
AQP3 aquaporin 3 (Gill blood group)
ATF6B activating transcription factor 6 beta
ATF7IP activating transcription factor 7 interacting protein
BBC3 BCL2 binding component 3
BMPR1B bone morphogenetic protein receptor, type IB
C3 complement component 3
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CAMKMT calmodulin-lysine N-methyltransferase
CCL5 chemokine (C-C motif) ligand 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2 cyclin-dependent kinase 2
CEMIP cell migration inducing protein, hyaluronan binding
CEMP1 cementum protein 1
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CTH cystathionine gamma-lyase
CUL3 cullin 3
CXCL5 chemokine (C-X-C motif) ligand 5
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
CYTH1 cytohesin 1
DGKE diacylglycerol kinase, epsilon 64kDa
DMBT1 deleted in malignant brain tumors 1
DUSP1 dual specificity phosphatase 1
EDIL3 EGF-like repeats and discoidin I-like domains 3
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXO40 F-box protein 40
FGF21 fibroblast growth factor 21
FOXP3 forkhead box P3
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
IL11 interleukin 11
IRX5 iroquois homeobox 5
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB8 integrin, beta 8
KCNIP2 Kv channel interacting protein 2
LARP7 La ribonucleoprotein domain family, member 7
LIPG lipase, endothelial
LMOD1 leiomodin 1 (smooth muscle)
LMTK2 lemur tyrosine kinase 2
LPL lipoprotein lipase
LRRC2 leucine rich repeat containing 2
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2
MAN2A2 mannosidase, alpha, class 2A, member 2
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MAP7 microtubule-associated protein 7
MNMIP1 manchette microtubule inner protein 1
MYBPC3 myosin binding protein C, cardiac
MYO15A myosin XVA
N4BP1 NEDD4 binding protein 1
NIPAL2 NIPA-like domain containing 2
NPC1 Niemann-Pick disease, type C1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG1 neuregulin 1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
POU6F2 POU class 6 homeobox 2
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRLH prolactin releasing hormone
PRPF18 pre-mRNA processing factor 18
PTGES prostaglandin E synthase
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RNF122 ring finger protein 122
RNGTT RNA guanylyltransferase and 5'-phosphatase
RUNX1 runt-related transcription factor 1
SFRP4 secreted frizzled-related protein 4
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SH3PXD2A SH3 and PX domains 2A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPINK5 serine peptidase inhibitor, Kazal type 5
STATH statherin
STC1 stanniocalcin 1
SUGP1 SURP and G patch domain containing 1
SYT2 synaptotagmin II
TBL1Y transducin (beta)-like 1, Y-linked
THPO thrombopoietin
TLR4 toll-like receptor 4
TRIM3 tripartite motif containing 3
TSPAN2 tetraspanin 2
TUBA3C tubulin, alpha 3c
UBA7 ubiquitin-like modifier activating enzyme 7
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZMAT4 zinc finger, matrin-type 4
ZNF609 zinc finger protein 609
ZNF76 zinc finger protein 76
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACE angiotensin I converting enzyme
ADRB2 adrenoceptor beta 2, surface
AMBRA1 autophagy/beclin-1 regulator 1
ANKRD40 ankyrin repeat domain 40
ANXA2P3 annexin A2 pseudogene 3
APOC4 apolipoprotein C-IV
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
AUH AU RNA binding protein/enoyl-CoA hydratase
BTBD2 BTB (POZ) domain containing 2
BTF3P12 basic transcription factor 3 pseudogene 12
C1ORF105 chromosome 1 open reading frame 105
C5ORF42 chromosome 5 open reading frame 42
C5ORF45 chromosome 5 open reading frame 45
C7ORF69 chromosome 7 open reading frame 69
C9ORF40 chromosome 9 open reading frame 40
CASS4 Cas scaffolding protein family member 4
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPT centromere protein T
CIDEC cell death-inducing DFFA-like effector c
CISH cytokine inducible SH2-containing protein
CLDN1 claudin 1
CLDN14 claudin 14
CLEC2B C-type lectin domain family 2, member B
CNN1 calponin 1, basic, smooth muscle
COG4 component of oligomeric golgi complex 4
CORT cortistatin
CPED1 cadherin-like and PC-esterase domain containing 1
CPZ carboxypeptidase Z
CRYBA2 crystallin, beta A2
CTC1 CTS telomere maintenance complex component 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DNM3 dynamin 3
DTX2 deltex 2, E3 ubiquitin ligase
ELOVL4 ELOVL fatty acid elongase 4
EN2 engrailed homeobox 2
FBXO2 F-box protein 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGL1 fibrinogen-like 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXRED2 FAD-dependent oxidoreductase domain containing 2
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GIF gastric intrinsic factor (vitamin B synthesis)
GPATCH3 G patch domain containing 3
GPC3 glypican 3
GRB7 growth factor receptor-bound protein 7
GREB1L growth regulation by estrogen in breast cancer-like
GREM1 gremlin 1, DAN family BMP antagonist
HIST1H4E histone cluster 1, H4e
HLX H2.0-like homeobox
IFI6 interferon, alpha-inducible protein 6
IFT140 intraflagellar transport 140
IL17RA interleukin 17 receptor A
INF2 inverted formin, FH2 and WH2 domain containing
IRF2BP1 interferon regulatory factor 2 binding protein 1
KDM8 lysine (K)-specific demethylase 8
KRT31 keratin 31, type I
LINC00597 long intergenic non-protein coding RNA 597
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MTSS1L metastasis suppressor 1-like
MUTYH mutY homolog
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NPM3 nucleophosmin/nucleoplasmin 3
NPY1R neuropeptide Y receptor Y1
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
OLFML3 olfactomedin-like 3
PCDH12 protocadherin 12
PCDHA5 protocadherin alpha 5
PLA2G15 phospholipase A2, group XV
PLCD1 phospholipase C, delta 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRAMEF10 PRAME family member 10
PTK6 protein tyrosine kinase 6
PTX3 pentraxin 3, long
QSER1 glutamine and serine rich 1
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RWDD2A RWD domain containing 2A
SCAMP5 secretory carrier membrane protein 5
SEC14L2 SEC14-like 2 (S. cerevisiae)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SMAD7 SMAD family member 7
SPRYD7 SPRY domain containing 7
TBC1D22B TBC1 domain family, member 22B
THOP1 thimet oligopeptidase 1
TMEM132A transmembrane protein 132A
TMEM212 transmembrane protein 212
TUBA3D tubulin, alpha 3d
WNT1 wingless-type MMTV integration site family, member 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZNF215 zinc finger protein 215
ZNF254 zinc finger protein 254
ZNF34 zinc finger protein 34
ZNF37BP zinc finger protein 37B, pseudogene