metaphase_anaphase_telophase_15min_noscapine_release vs ctrl_HeLa (Human) [19691289] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs
Category proteomics
Type drug perturbation
Description drug perturbation identified as [drug perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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Genes

432 proteins differentially phosphorylated following the metaphase_anaphase_telophase_15min_noscapine_release vs ctrl_HeLa (Human) [19691289] drug perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.

increased phosphorylation

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACIN1 apoptotic chromatin condensation inducer 1
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADNP activity-dependent neuroprotector homeobox
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
AHCTF1P1 AT hook containing transcription factor 1 pseudogene 1
AHNAK AHNAK nucleoprotein
AKAP8 A kinase (PRKA) anchor protein 8
AMOTL1 angiomotin like 1
AMOTL2 angiomotin like 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC2 anaphase promoting complex subunit 2
ANKRD32 ankyrin repeat domain 32
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATAD2B ATPase family, AAA domain containing 2B
ATAD5 ATPase family, AAA domain containing 5
ATP13A1 ATPase type 13A1
ATXN2L ataxin 2-like
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCLAF1 BCL2-associated transcription factor 1
BCORL1 BCL6 corepressor-like 1
BLM Bloom syndrome, RecQ helicase-like
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMS1 BMS1 ribosome biogenesis factor
BRD1 bromodomain containing 1
BRD8 bromodomain containing 8
BRPF1 bromodomain and PHD finger containing, 1
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
BUD13 BUD13 homolog (S. cerevisiae)
BYSL bystin-like
C10ORF12 chromosome 10 open reading frame 12
C11ORF30 chromosome 11 open reading frame 30
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
CANX calnexin
CASC5 cancer susceptibility candidate 5
CBX5 chromobox homolog 5
CBX8 chromobox homolog 8
CCDC86 coiled-coil domain containing 86
CDC27 cell division cycle 27
CDCA2 cell division cycle associated 2
CDCA5 cell division cycle associated 5
CDCA8 cell division cycle associated 8
CDYL chromodomain protein, Y-like
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPB centromere protein B, 80kDa
CENPC centromere protein C
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CENPH centromere protein H
CENPJ centromere protein J
CENPN centromere protein N
CENPT centromere protein T
CEP170 centrosomal protein 170kDa
CEP55 centrosomal protein 55kDa
CEP57 centrosomal protein 57kDa
CERS2 ceramide synthase 2
CHD1 chromodomain helicase DNA binding protein 1
CHMP2B charged multivesicular body protein 2B
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CIT citron rho-interacting serine/threonine kinase
CKAP2L cytoskeleton associated protein 2-like
CKAP5 cytoskeleton associated protein 5
CLASP1 cytoplasmic linker associated protein 1
CLIP1 CAP-GLY domain containing linker protein 1
CNTLN centlein, centrosomal protein
COG1 component of oligomeric golgi complex 1
COIL coilin
COPA coatomer protein complex, subunit alpha
CTTN cortactin
DCTN1 dynactin 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DIDO1 death inducer-obliterator 1
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DOCK7 dedicator of cytokinesis 7
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
DSG2 desmoglein 2
DSN1 DSN1, MIS12 kinetochore complex component
DSP desmoplakin
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EBNA1BP2 EBNA1 binding protein 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EP400 E1A binding protein p400
ERCC6 excision repair cross-complementation group 6
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
EVPL envoplakin
FAM208A family with sequence similarity 208, member A
FAM208B family with sequence similarity 208, member B
FAM83B family with sequence similarity 83, member B
FAM83H family with sequence similarity 83, member H
FANCD2 Fanconi anemia, complementation group D2
FANCI Fanconi anemia, complementation group I
FBL fibrillarin
FKBP15 FK506 binding protein 15, 133kDa
FLYWCH1 FLYWCH-type zinc finger 1
FTSJ3 FtsJ homolog 3 (E. coli)
GOLGA2 golgin A2
GSG2 germ cell associated 2 (haspin)
GTSE1 G-2 and S-phase expressed 1
H1FX H1 histone family, member X
HAUS6 HAUS augmin-like complex, subunit 6
HCFC1 host cell factor C1
HEATR1 HEAT repeat containing 1
HIST1H1B histone cluster 1, H1b
HIST1H1C histone cluster 1, H1c
HMG20A high mobility group 20A
HP1BP3 heterochromatin protein 1, binding protein 3
HSPB1 heat shock 27kDa protein 1
HTATSF1 HIV-1 Tat specific factor 1
INADL InaD-like (Drosophila)
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
IWS1 IWS1 homolog (S. cerevisiae)
JPH1 junctophilin 1
KAT7 K(lysine) acetyltransferase 7
KDM5A lysine (K)-specific demethylase 5A
KIAA1671 KIAA1671
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
KIF4A kinesin family member 4A
KIF4B kinesin family member 4B
KIFC1 kinesin family member C1
KIFC3 kinesin family member C3
KMT2A lysine (K)-specific methyltransferase 2A
KMT2B lysine (K)-specific methyltransferase 2B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRI1 KRI1 homolog (S. cerevisiae)
KTN1 kinectin 1 (kinesin receptor)
LAS1L LAS1-like (S. cerevisiae)
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
LIMA1 LIM domain and actin binding 1
LMNA lamin A/C
LMNB1 lamin B1
LMNB2 lamin B2
LMO7 LIM domain 7
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAP4 microtubule-associated protein 4
MAP7 microtubule-associated protein 7
MAP7D1 MAP7 domain containing 1
MAP7D3 MAP7 domain containing 3
MARK2 MAP/microtubule affinity-regulating kinase 2
MIER1 mesoderm induction early response 1, transcriptional regulator
MISP mitotic spindle positioning
MKI67 marker of proliferation Ki-67
MON2 MON2 homolog (S. cerevisiae)
MPHOSPH8 M-phase phosphoprotein 8
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MPRIP myosin phosphatase Rho interacting protein
MSH6 mutS homolog 6
MTA1 metastasis associated 1
MTCL1 microtubule crosslinking factor 1
MYBBP1A MYB binding protein (P160) 1a
MYO1C myosin IC
MYPN myopalladin
NAT10 N-acetyltransferase 10 (GCN5-related)
NAV1 neuron navigator 1
NCAPD2 non-SMC condensin I complex, subunit D2
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPG2 non-SMC condensin II complex, subunit G2
NCAPH non-SMC condensin I complex, subunit H
NDC1 NDC1 transmembrane nucleoporin
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NF1 neurofibromin 1
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NHP2 NHP2 ribonucleoprotein
NIFK nucleolar protein interacting with the FHA domain of MKI67
NIPBL Nipped-B homolog (Drosophila)
NMD3 NMD3 ribosome export adaptor
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NOL8 nucleolar protein 8
NOP14 NOP14 nucleolar protein
NOP2 NOP2 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NOP58 NOP58 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSL1 NSL1, MIS12 kinetochore complex component
NUMA1 nuclear mitotic apparatus protein 1
NUP107 nucleoporin 107kDa
NUP153 nucleoporin 153kDa
NUP188 nucleoporin 188kDa
NUP214 nucleoporin 214kDa
NUP35 nucleoporin 35kDa
NUP98 nucleoporin 98kDa
OFD1 oral-facial-digital syndrome 1
PALMD palmdelphin
PAPD5 PAP associated domain containing 5
PBRM1 polybromo 1
PCM1 pericentriolar material 1
PCNT pericentrin
PDCD11 programmed cell death 11
PELP1 proline, glutamate and leucine rich protein 1
PES1 pescadillo ribosomal biogenesis factor 1
PHF12 PHD finger protein 12
PHF14 PHD finger protein 14
PHF8 PHD finger protein 8
PHIP pleckstrin homology domain interacting protein
PHLDB2 pleckstrin homology-like domain, family B, member 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PKP2 plakophilin 2
PKP4 plakophilin 4
PLEC plectin
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PMF1 polyamine-modulated factor 1
PNN pinin, desmosome associated protein
PNPLA6 patatin-like phospholipase domain containing 6
POGZ pogo transposable element with ZNF domain
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POM121C POM121 transmembrane nucleoporin C
POP1 processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)
PPAN peter pan homolog (Drosophila)
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPHLN1 periphilin 1
PPL periplakin
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PRC1 protein regulator of cytokinesis 1
PRPF4B pre-mRNA processing factor 4B
PRR11 proline rich 11
PRRC2A proline-rich coiled-coil 2A
PRRC2C proline-rich coiled-coil 2C
PSRC1 proline/serine-rich coiled-coil 1
PTRF polymerase I and transcript release factor
RAD18 RAD18 E3 ubiquitin protein ligase
RAI1 retinoic acid induced 1
RANBP2 RAN binding protein 2
RBM14 RNA binding motif protein 14
RBM33 RNA binding motif protein 33
RBM34 RNA binding motif protein 34
RBMX2 RNA binding motif protein, X-linked 2
RGPD8 RANBP2-like and GRIP domain containing 8
RICTOR RPTOR independent companion of MTOR, complex 2
RNF169 ring finger protein 169
RNF2 ring finger protein 2
RPL12 ribosomal protein L12
RPL23A ribosomal protein L23a
RPL26L1 ribosomal protein L26-like 1
RPL28 ribosomal protein L28
RPL30 ribosomal protein L30
RPL34 ribosomal protein L34
RPLP2 ribosomal protein, large, P2
RPS27A ribosomal protein S27a
RPS3 ribosomal protein S3
RRBP1 ribosome binding protein 1
RRP1 ribosomal RNA processing 1
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RSL1D1 ribosomal L1 domain containing 1
SAP130 Sin3A-associated protein, 130kDa
SCAF1 SR-related CTD-associated factor 1
SCAPER S-phase cyclin A-associated protein in the ER
SDAD1 SDA1 domain containing 1
SEC16A SEC16 homolog A (S. cerevisiae)
SETX senataxin
SGOL2 shugoshin-like 2 (S. pombe)
SIN3A SIN3 transcription regulator family member A
SIPA1L1 signal-induced proliferation-associated 1 like 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLTM SAFB-like, transcription modulator
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMC1A structural maintenance of chromosomes 1A
SMC4 structural maintenance of chromosomes 4
SMN1 survival of motor neuron 1, telomeric
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SOGA1 suppressor of glucose, autophagy associated 1
SPAG5 sperm associated antigen 5
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
SPICE1 spindle and centriole associated protein 1
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
SQSTM1 sequestosome 1
SRFBP1 serum response factor binding protein 1
SRP72 signal recognition particle 72kDa
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
SSFA2 sperm specific antigen 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
ST7 suppression of tumorigenicity 7
STOML2 stomatin (EPB72)-like 2
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae)
SURF6 surfeit 6
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SVIL supervillin
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNPO synaptopodin
TCOF1 Treacher Collins-Franceschetti syndrome 1
THRAP3 thyroid hormone receptor associated protein 3
TMEM201 transmembrane protein 201
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TPR translocated promoter region, nuclear basket protein
TPX2 TPX2, microtubule-associated
TRAFD1 TRAF-type zinc finger domain containing 1
TRIM27 tripartite motif containing 27
TRIM28 tripartite motif containing 28
TTF1 transcription termination factor, RNA polymerase I
TTI1 TELO2 interacting protein 1
TTN titin
TUBA1C tubulin, alpha 1c
TUBA4A tubulin, alpha 4a
UBAP2L ubiquitin associated protein 2-like
USP36 ubiquitin specific peptidase 36
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast)
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
VDAC2 voltage-dependent anion channel 2
VIM vimentin
WAPAL wings apart-like homolog (Drosophila)
WDR43 WD repeat domain 43
WDR62 WD repeat domain 62
WDR74 WD repeat domain 74
WHSC1 Wolf-Hirschhorn syndrome candidate 1
WIZ widely interspaced zinc finger motifs
YEATS2 YEATS domain containing 2
ZC3H11A zinc finger CCCH-type containing 11A
ZFC3H1 zinc finger, C3H1-type containing
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZMYM4 zinc finger, MYM-type 4
ZMYND8 zinc finger, MYND-type containing 8
ZNF106 zinc finger protein 106
ZNF280C zinc finger protein 280C
ZNF512B zinc finger protein 512B
ZNF638 zinc finger protein 638
ZNF644 zinc finger protein 644
ZNF687 zinc finger protein 687
ZWINT ZW10 interacting kinetochore protein
ZZZ3 zinc finger, ZZ-type containing 3

decreased phosphorylation

Symbol Name
AKAP17A A kinase (PRKA) anchor protein 17A
BRAT1 BRCA1-associated ATM activator 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C18ORF21 chromosome 18 open reading frame 21
C1ORF131 chromosome 1 open reading frame 131
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CCDC137 coiled-coil domain containing 137
CCDC18 coiled-coil domain containing 18
CCP110 centriolar coiled coil protein 110kDa
CDC7 cell division cycle 7
CEP135 centrosomal protein 135kDa
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHTOP chromatin target of PRMT1
CLASP2 cytoplasmic linker associated protein 2
CSNK1A1 casein kinase 1, alpha 1
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DHCR7 7-dehydrocholesterol reductase
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
EXOSC2 exosome component 2
EXOSC9 exosome component 9
GAS2L3 growth arrest-specific 2 like 3
GEMIN5 gem (nuclear organelle) associated protein 5
GLE1 GLE1 RNA export mediator
H1F0 H1 histone family, member 0
H2AFY H2A histone family, member Y
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPS5 Hermansky-Pudlak syndrome 5
ICE1 interactor of little elongation complex ELL subunit 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INO80 INO80 complex subunit
KCTD10 potassium channel tetramerization domain containing 10
KIF14 kinesin family member 14
KIF18A kinesin family member 18A
KIF22 kinesin family member 22
KPNA6 karyopherin alpha 6 (importin alpha 7)
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
MTPAP mitochondrial poly(A) polymerase
NDC80 NDC80 kinetochore complex component
NF2 neurofibromin 2 (merlin)
NOTCH2 notch 2
NUP210 nucleoporin 210kDa
NUP43 nucleoporin 43kDa
NUP85 nucleoporin 85kDa
NUP88 nucleoporin 88kDa
PAK1IP1 PAK1 interacting protein 1
PARP1 poly (ADP-ribose) polymerase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POC5 POC5 centriolar protein
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLRMT polymerase (RNA) mitochondrial (DNA directed)
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PWWP2A PWWP domain containing 2A
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RPL19 ribosomal protein L19
RPL26 ribosomal protein L26
RPS13 ribosomal protein S13
RPS24 ribosomal protein S24
RPS5 ribosomal protein S5
SAMD1 sterile alpha motif domain containing 1
SHCBP1 SHC SH2-domain binding protein 1
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC2 structural maintenance of chromosomes 2
TAOK2 TAO kinase 2
TIMELESS timeless circadian clock
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TUBB4B tubulin, beta 4B class IVb
UBTF upstream binding transcription factor, RNA polymerase I
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
WDR46 WD repeat domain 46
ZBTB40 zinc finger and BTB domain containing 40
ZMYND11 zinc finger, MYND-type containing 11
ZNF574 zinc finger protein 574