metaphase_anaphase_telophase_60min_noscapine_release vs ctrl_HeLa (Human) [19691289] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs
Category proteomics
Type drug perturbation
Description drug perturbation identified as [drug perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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Genes

336 proteins differentially phosphorylated following the metaphase_anaphase_telophase_60min_noscapine_release vs ctrl_HeLa (Human) [19691289] drug perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Drugs dataset.

increased phosphorylation

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ACIN1 apoptotic chromatin condensation inducer 1
AFAP1 actin filament associated protein 1
AHCTF1P1 AT hook containing transcription factor 1 pseudogene 1
AHNAK AHNAK nucleoprotein
AKAP8 A kinase (PRKA) anchor protein 8
AMOTL2 angiomotin like 2
ANKRD32 ankyrin repeat domain 32
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
ARHGAP11A Rho GTPase activating protein 11A
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD5 ATPase family, AAA domain containing 5
ATXN2L ataxin 2-like
AURKB aurora kinase B
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BRD1 bromodomain containing 1
BUD13 BUD13 homolog (S. cerevisiae)
BYSL bystin-like
C10ORF12 chromosome 10 open reading frame 12
C11ORF30 chromosome 11 open reading frame 30
C18ORF21 chromosome 18 open reading frame 21
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
CBX5 chromobox homolog 5
CCDC18 coiled-coil domain containing 18
CCDC86 coiled-coil domain containing 86
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPF centromere protein F, 350/400kDa
CENPI centromere protein I
CENPJ centromere protein J
CENPT centromere protein T
CENPU centromere protein U
CEP170 centrosomal protein 170kDa
CEP55 centrosomal protein 55kDa
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHMP2B charged multivesicular body protein 2B
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
CIT citron rho-interacting serine/threonine kinase
CLIP1 CAP-GLY domain containing linker protein 1
CSNK1A1 casein kinase 1, alpha 1
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56
DIDO1 death inducer-obliterator 1
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DOCK7 dedicator of cytokinesis 7
DSG2 desmoglein 2
DSN1 DSN1, MIS12 kinetochore complex component
DSP desmoplakin
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ERCC6L excision repair cross-complementation group 6-like
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae)
EXOSC9 exosome component 9
FAM208B family with sequence similarity 208, member B
FAM83B family with sequence similarity 83, member B
FAM83H family with sequence similarity 83, member H
FANCD2 Fanconi anemia, complementation group D2
FBL fibrillarin
FKBP15 FK506 binding protein 15, 133kDa
FTSJ3 FtsJ homolog 3 (E. coli)
GEMIN5 gem (nuclear organelle) associated protein 5
GLE1 GLE1 RNA export mediator
GTSE1 G-2 and S-phase expressed 1
H1FX H1 histone family, member X
HEATR1 HEAT repeat containing 1
HIST1H1B histone cluster 1, H1b
HP1BP3 heterochromatin protein 1, binding protein 3
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPB1 heat shock 27kDa protein 1
HTATSF1 HIV-1 Tat specific factor 1
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
IWS1 IWS1 homolog (S. cerevisiae)
KANSL1 KAT8 regulatory NSL complex subunit 1
KAT7 K(lysine) acetyltransferase 7
KCTD10 potassium channel tetramerization domain containing 10
KDM5A lysine (K)-specific demethylase 5A
KIAA1671 KIAA1671
KIF15 kinesin family member 15
KIF18A kinesin family member 18A
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
KIF4A kinesin family member 4A
KIF4B kinesin family member 4B
KMT2A lysine (K)-specific methyltransferase 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRI1 KRI1 homolog (S. cerevisiae)
KTN1 kinectin 1 (kinesin receptor)
LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
LMNB2 lamin B2
LMO7 LIM domain 7
MACF1 microtubule-actin crosslinking factor 1
MAP7 microtubule-associated protein 7
MAP7D1 MAP7 domain containing 1
MAP7D3 MAP7 domain containing 3
MCM2 minichromosome maintenance complex component 2
MIER1 mesoderm induction early response 1, transcriptional regulator
MISP mitotic spindle positioning
MKI67 marker of proliferation Ki-67
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
MPP5 membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
MPRIP myosin phosphatase Rho interacting protein
MSH6 mutS homolog 6
MTA1 metastasis associated 1
MTCL1 microtubule crosslinking factor 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYBBP1A MYB binding protein (P160) 1a
MYH9 myosin, heavy chain 9, non-muscle
MYO1C myosin IC
MYPN myopalladin
NDC80 NDC80 kinetochore complex component
NES nestin
NFRKB nuclear factor related to kappaB binding protein
NGDN neuroguidin, EIF4E binding protein
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL6 nucleolar protein 6 (RNA-associated)
NOL8 nucleolar protein 8
NOP14 NOP14 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NUMA1 nuclear mitotic apparatus protein 1
NUP153 nucleoporin 153kDa
NUP188 nucleoporin 188kDa
NUP210 nucleoporin 210kDa
NUP214 nucleoporin 214kDa
NUP35 nucleoporin 35kDa
NUP43 nucleoporin 43kDa
NUP85 nucleoporin 85kDa
NUP88 nucleoporin 88kDa
NUP93 nucleoporin 93kDa
NUP98 nucleoporin 98kDa
PAXBP1 PAX3 and PAX7 binding protein 1
PBRM1 polybromo 1
PCM1 pericentriolar material 1
PDS5B PDS5 cohesin associated factor B
PES1 pescadillo ribosomal biogenesis factor 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PHF12 PHD finger protein 12
PHF14 PHD finger protein 14
PHF8 PHD finger protein 8
PHIP pleckstrin homology domain interacting protein
PKP2 plakophilin 2
PKP4 plakophilin 4
PLEC plectin
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PMF1 polyamine-modulated factor 1
PNN pinin, desmosome associated protein
PNPLA6 patatin-like phospholipase domain containing 6
POGZ pogo transposable element with ZNF domain
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PRC1 protein regulator of cytokinesis 1
PRPF4B pre-mRNA processing factor 4B
PRPF6 pre-mRNA processing factor 6
PRR11 proline rich 11
PRRC2A proline-rich coiled-coil 2A
PSRC1 proline/serine-rich coiled-coil 1
PTRF polymerase I and transcript release factor
PWP1 PWP1 homolog (S. cerevisiae)
RACGAP1 Rac GTPase activating protein 1
RAD18 RAD18 E3 ubiquitin protein ligase
RAI1 retinoic acid induced 1
RAI14 retinoic acid induced 14
RANBP2 RAN binding protein 2
RBM33 RNA binding motif protein 33
RFC1 replication factor C (activator 1) 1, 145kDa
RPL12 ribosomal protein L12
RPL23A ribosomal protein L23a
RPL26L1 ribosomal protein L26-like 1
RPLP2 ribosomal protein, large, P2
RPS27A ribosomal protein S27a
RPS3 ribosomal protein S3
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SCAF1 SR-related CTD-associated factor 1
SEC16A SEC16 homolog A (S. cerevisiae)
SGOL2 shugoshin-like 2 (S. pombe)
SHCBP1 SHC SH2-domain binding protein 1
SIN3A SIN3 transcription regulator family member A
SLC38A1 solute carrier family 38, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMC4 structural maintenance of chromosomes 4
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SOGA1 suppressor of glucose, autophagy associated 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
SRSF6 serine/arginine-rich splicing factor 6
SSFA2 sperm specific antigen 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic)
SUZ12 SUZ12 polycomb repressive complex 2 subunit
SVIL supervillin
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNM synemin, intermediate filament protein
SYNPO synaptopodin
SYNRG synergin, gamma
TAOK2 TAO kinase 2
TCF20 transcription factor 20 (AR1)
TCOF1 Treacher Collins-Franceschetti syndrome 1
THRAP3 thyroid hormone receptor associated protein 3
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TPR translocated promoter region, nuclear basket protein
TPX2 TPX2, microtubule-associated
TRIM27 tripartite motif containing 27
TTF1 transcription termination factor, RNA polymerase I
TTN titin
TUBA1C tubulin, alpha 1c
TUBA4A tubulin, alpha 4a
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast)
VIM vimentin
WDR62 WD repeat domain 62
ZFC3H1 zinc finger, C3H1-type containing
ZNF106 zinc finger protein 106
ZNF512B zinc finger protein 512B

decreased phosphorylation

Symbol Name
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AKAP17A A kinase (PRKA) anchor protein 17A
AMOTL1 angiomotin like 1
ANAPC2 anaphase promoting complex subunit 2
ATAD2B ATPase family, AAA domain containing 2B
BCORL1 BCL6 corepressor-like 1
BLM Bloom syndrome, RecQ helicase-like
BRAT1 BRCA1-associated ATM activator 1
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C1ORF131 chromosome 1 open reading frame 131
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CASC5 cancer susceptibility candidate 5
CCDC137 coiled-coil domain containing 137
CCP110 centriolar coiled coil protein 110kDa
CDC7 cell division cycle 7
CDCA5 cell division cycle associated 5
CENPB centromere protein B, 80kDa
CENPH centromere protein H
CEP135 centrosomal protein 135kDa
CEP57 centrosomal protein 57kDa
CHTOP chromatin target of PRMT1
CKAP2L cytoskeleton associated protein 2-like
CLASP2 cytoplasmic linker associated protein 2
CNTLN centlein, centrosomal protein
COG1 component of oligomeric golgi complex 1
DCTN1 dynactin 1
DHCR7 7-dehydrocholesterol reductase
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
EBNA1BP2 EBNA1 binding protein 2
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
ERCC6 excision repair cross-complementation group 6
EVPL envoplakin
EXOSC2 exosome component 2
FLYWCH1 FLYWCH-type zinc finger 1
GAS2L3 growth arrest-specific 2 like 3
GOLGA2 golgin A2
GSG2 germ cell associated 2 (haspin)
H1F0 H1 histone family, member 0
H2AFY H2A histone family, member Y
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPS5 Hermansky-Pudlak syndrome 5
ICE1 interactor of little elongation complex ELL subunit 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INO80 INO80 complex subunit
JPH1 junctophilin 1
KIF14 kinesin family member 14
KIF22 kinesin family member 22
KIFC1 kinesin family member C1
KIFC3 kinesin family member C3
KPNA6 karyopherin alpha 6 (importin alpha 7)
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)
LAS1L LAS1-like (S. cerevisiae)
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MTPAP mitochondrial poly(A) polymerase
NAT10 N-acetyltransferase 10 (GCN5-related)
NCAPD3 non-SMC condensin II complex, subunit D3
NDC1 NDC1 transmembrane nucleoporin
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NF2 neurofibromin 2 (merlin)
NHP2 NHP2 ribonucleoprotein
NOTCH2 notch 2
NSL1 NSL1, MIS12 kinetochore complex component
OFD1 oral-facial-digital syndrome 1
PAK1IP1 PAK1 interacting protein 1
PARP1 poly (ADP-ribose) polymerase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POC5 POC5 centriolar protein
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLRMT polymerase (RNA) mitochondrial (DNA directed)
PPP1R9A protein phosphatase 1, regulatory subunit 9A
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PWWP2A PWWP domain containing 2A
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae)
RGPD8 RANBP2-like and GRIP domain containing 8
RNF169 ring finger protein 169
RPL19 ribosomal protein L19
RPL26 ribosomal protein L26
RPL28 ribosomal protein L28
RPL34 ribosomal protein L34
RPS13 ribosomal protein S13
RPS24 ribosomal protein S24
RPS5 ribosomal protein S5
SAMD1 sterile alpha motif domain containing 1
SAP130 Sin3A-associated protein, 130kDa
SCAPER S-phase cyclin A-associated protein in the ER
SETX senataxin
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SMC2 structural maintenance of chromosomes 2
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
ST7 suppression of tumorigenicity 7
STOML2 stomatin (EPB72)-like 2
SURF6 surfeit 6
TIMELESS timeless circadian clock
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TUBB4B tubulin, beta 4B class IVb
UBTF upstream binding transcription factor, RNA polymerase I
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast)
VDAC2 voltage-dependent anion channel 2
WDR46 WD repeat domain 46
WDR74 WD repeat domain 74
ZBTB40 zinc finger and BTB domain containing 40
ZKSCAN8 zinc finger with KRAB and SCAN domains 8
ZMYND11 zinc finger, MYND-type containing 11
ZNF574 zinc finger protein 574