metformin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A member of the class of guanidines that is the 1,1-dimethyl derivative of biguanide. (Chemical Entities of Biological Interest Ontology, CHEBI_6801)
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Genes

63 genes co-occuring with the biological term metformin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ADIPOQ adiponectin, C1Q and collagen domain containing
AMH anti-Mullerian hormone
AR androgen receptor
ATF1 activating transcription factor 1
ATM ATM serine/threonine kinase
C1QTNF3 C1q and tumor necrosis factor related protein 3
CAPN10 calpain 10
CAV1 caveolin 1, caveolae protein, 22kDa
CCND1 cyclin D1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CGRRF1 cell growth regulator with ring finger domain 1
CRH corticotropin releasing hormone
CRP C-reactive protein, pentraxin-related
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DPP4 dipeptidyl-peptidase 4
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
FOXO3 forkhead box O3
IAPP islet amyloid polypeptide
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IL6 interleukin 6
IRS1 insulin receptor substrate 1
LEP leptin
LEPR leptin receptor
LPL lipoprotein lipase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPT microtubule-associated protein tau
MID1 midline 1
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NPPB natriuretic peptide B
NR0B2 nuclear receptor subfamily 0, group B, member 2
PID1 phosphotyrosine interaction domain containing 1
POU2F1 POU class 2 homeobox 1
POU2F2 POU class 2 homeobox 2
PPARG peroxisome proliferator-activated receptor gamma
PTEN phosphatase and tensin homolog
RNF115 ring finger protein 115
SAA1 serum amyloid A1
SEPP1 selenoprotein P, plasma, 1
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SHBG sex hormone-binding globulin
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC47A2 solute carrier family 47 (multidrug and toxin extrusion), member 2
SNCA synuclein, alpha (non A4 component of amyloid precursor)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK11 serine/threonine kinase 11
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS1 thrombospondin 1
TP53 tumor protein p53
UCN urocortin
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A