methapyrilene-4990 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the methapyrilene-4990 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADRA1D adrenoceptor alpha 1D
APC adenomatous polyposis coli
APOE apolipoprotein E
BLVRA biliverdin reductase A
C7ORF26 chromosome 7 open reading frame 26
C7ORF69 chromosome 7 open reading frame 69
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALD1 caldesmon 1
CASC1 cancer susceptibility candidate 1
CCDC71 coiled-coil domain containing 71
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLCN7 chloride channel, voltage-sensitive 7
CLEC11A C-type lectin domain family 11, member A
CLTA clathrin, light chain A
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL6A1 collagen, type VI, alpha 1
CTSZ cathepsin Z
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DOPEY2 dopey family member 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERO1LB ERO1-like beta (S. cerevisiae)
FLJ11292
FOSL2 FOS-like antigen 2
FSCN1 fascin actin-bundling protein 1
GJA8 gap junction protein, alpha 8, 50kDa
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GRPR gastrin-releasing peptide receptor
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HAMP hepcidin antimicrobial peptide
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IFI35 interferon-induced protein 35
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL24 interleukin 24
IRF4 interferon regulatory factor 4
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KIAA1456 KIAA1456
LAMA2 laminin, alpha 2
LAMC2 laminin, gamma 2
LIME1 Lck interacting transmembrane adaptor 1
LINC01587 long intergenic non-protein coding RNA 1587
MAP2K7 mitogen-activated protein kinase kinase 7
MAPK7 mitogen-activated protein kinase 7
MAST3 microtubule associated serine/threonine kinase 3
MBD2 methyl-CpG binding domain protein 2
MBNL2 muscleblind-like splicing regulator 2
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MTSS1L metastasis suppressor 1-like
MUC3A mucin 3A, cell surface associated
MXD4 MAX dimerization protein 4
MYO1F myosin IF
MYO7A myosin VIIA
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NEB nebulin
NHLH2 nescient helix loop helix 2
NOD2 nucleotide-binding oligomerization domain containing 2
NOL10 nucleolar protein 10
NR2F1 nuclear receptor subfamily 2, group F, member 1
OCA2 oculocutaneous albinism II
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PAX5 paired box 5
PDE12 phosphodiesterase 12
PEX5L peroxisomal biogenesis factor 5-like
PILRA paired immunoglobin-like type 2 receptor alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
POU1F1 POU class 1 homeobox 1
PRB1 proline-rich protein BstNI subfamily 1
PVT1 Pvt1 oncogene (non-protein coding)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF126P1 ring finger protein 126 pseudogene 1
RPA4 replication protein A4, 30kDa
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RUNX1 runt-related transcription factor 1
SCLY selenocysteine lyase
SETBP1 SET binding protein 1
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SNRPN small nuclear ribonucleoprotein polypeptide N
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRCAP Snf2-related CREBBP activator protein
STAB2 stabilin 2
TAGLN3 transgelin 3
TBXA2R thromboxane A2 receptor
TCF3 transcription factor 3
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding)
THBS1 thrombospondin 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRAIP TRAF interacting protein
TRD T cell receptor delta locus
UROD uroporphyrinogen decarboxylase
VAC14 Vac14 homolog (S. cerevisiae)
ZNF204P zinc finger protein 204, pseudogene

decreased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADM adrenomedullin
ALG12 ALG12, alpha-1,6-mannosyltransferase
AMDHD2 amidohydrolase domain containing 2
ANKRD28 ankyrin repeat domain 28
C17ORF70 chromosome 17 open reading frame 70
C1QTNF3 C1q and tumor necrosis factor related protein 3
CASP3 caspase 3, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDK3 cyclin-dependent kinase 3
CENPT centromere protein T
CHPF chondroitin polymerizing factor
CHRM3 cholinergic receptor, muscarinic 3
CIDEC cell death-inducing DFFA-like effector c
CLCF1 cardiotrophin-like cytokine factor 1
CLDN1 claudin 1
CLDN3 claudin 3
CLDN4 claudin 4
COPS7B COP9 signalosome subunit 7B
CPTP ceramide-1-phosphate transfer protein
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DUSP5 dual specificity phosphatase 5
ENO2 enolase 2 (gamma, neuronal)
EPPK1 epiplakin 1
FANCE Fanconi anemia, complementation group E
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRS2 fibroblast growth factor receptor substrate 2
GLI3 GLI family zinc finger 3
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GSTCD glutathione S-transferase, C-terminal domain containing
HLA-J major histocompatibility complex, class I, J (pseudogene)
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
HSPA2 heat shock 70kDa protein 2
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HYAL2 hyaluronoglucosaminidase 2
IDI2-AS1 IDI2 antisense RNA 1
IKZF5 IKAROS family zinc finger 5 (Pegasus)
IPO8 importin 8
LAMB2 laminin, beta 2 (laminin S)
LHX6 LIM homeobox 6
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRP5 low density lipoprotein receptor-related protein 5
LRRC61 leucine rich repeat containing 61
LYPLA2P1 lysophospholipase II pseudogene 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAP7D1 MAP7 domain containing 1
MAPK12 mitogen-activated protein kinase 12
MBTPS2 membrane-bound transcription factor peptidase, site 2
MT1HL1 metallothionein 1H-like 1
NCSTN nicastrin
NECAP2 NECAP endocytosis associated 2
NINL ninein-like
NPIPB3 nuclear pore complex interacting protein family, member B3
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PACS1 phosphofurin acidic cluster sorting protein 1
PCDHB3 protocadherin beta 3
PDLIM2 PDZ and LIM domain 2 (mystique)
PGP phosphoglycolate phosphatase
PHGDH phosphoglycerate dehydrogenase
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD3 phospholipase D family, member 3
POMT2 protein-O-mannosyltransferase 2
POU2F1 POU class 2 homeobox 1
PRODH proline dehydrogenase (oxidase) 1
PTGES2 prostaglandin E synthase 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAB5B RAB5B, member RAS oncogene family
RNF122 ring finger protein 122
RNF126 ring finger protein 126
RNF170 ring finger protein 170
RPH3AL rabphilin 3A-like (without C2 domains)
S100A4 S100 calcium binding protein A4
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SMTN smoothelin
SND1-IT1 SND1 intronic transcript 1
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae)
SYBU syntabulin (syntaxin-interacting)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMPRSS3 transmembrane protease, serine 3
TRMU tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
TTC33 tetratricopeptide repeat domain 33
TUBA3D tubulin, alpha 3d
TXLNG taxilin gamma
ULBP2 UL16 binding protein 2
USB1 U6 snRNA biogenesis 1
USP19 ubiquitin specific peptidase 19
ZNF324 zinc finger protein 324
ZNF668 zinc finger protein 668
ZNF862 zinc finger protein 862
ZNRD1-AS1 ZNRD1 antisense RNA 1