methapyrilene-6644 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the methapyrilene-6644 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACHE acetylcholinesterase (Yt blood group)
ACSS3 acyl-CoA synthetase short-chain family member 3
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ADGB androglobin
AKAP5 A kinase (PRKA) anchor protein 5
ANO2 anoctamin 2, calcium activated chloride channel
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ATM ATM serine/threonine kinase
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1
C17ORF53 chromosome 17 open reading frame 53
C4ORF19 chromosome 4 open reading frame 19
CASS4 Cas scaffolding protein family member 4
CD24 CD24 molecule
CD58 CD58 molecule
CDRT1 CMT1A duplicated region transcript 1
CEACAM3 carcinoembryonic antigen-related cell adhesion molecule 3
CGA glycoprotein hormones, alpha polypeptide
CLCN4 chloride channel, voltage-sensitive 4
CLDN18 claudin 18
CLEC4A C-type lectin domain family 4, member A
CNR2 cannabinoid receptor 2 (macrophage)
COBLL1 cordon-bleu WH2 repeat protein-like 1
COL14A1 collagen, type XIV, alpha 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DCHS2 dachsous cadherin-related 2
DCN decorin
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DOCK3 dedicator of cytokinesis 3
DOCK9 dedicator of cytokinesis 9
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
ELSPBP1 epididymal sperm binding protein 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FCAR Fc fragment of IgA receptor
FGFR4 fibroblast growth factor receptor 4
FH fumarate hydratase
FOXD3 forkhead box D3
FSCN3 fascin actin-bundling protein 3, testicular
GH1 growth hormone 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HABP4 hyaluronan binding protein 4
HEG1 heart development protein with EGF-like domains 1
HGD homogentisate 1,2-dioxygenase
HHAT hedgehog acyltransferase
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HNMT histamine N-methyltransferase
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXC11 homeobox C11
ICAM1 intercellular adhesion molecule 1
IL19 interleukin 19
INHBB inhibin, beta B
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JPH3 junctophilin 3
KANSL1L KAT8 regulatory NSL complex subunit 1-like
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLHL22 kelch-like family member 22
KRT34 keratin 34, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00115 long intergenic non-protein coding RNA 115
LOX lysyl oxidase
MED25 mediator complex subunit 25
MFAP3L microfibrillar-associated protein 3-like
MMP16 matrix metallopeptidase 16 (membrane-inserted)
NPY neuropeptide Y
OSBPL7 oxysterol binding protein-like 7
PDZK1 PDZ domain containing 1
PMP2 peripheral myelin protein 2
PQLC2 PQ loop repeat containing 2
PRDM14 PR domain containing 14
PRKG2 protein kinase, cGMP-dependent, type II
PSG9 pregnancy specific beta-1-glycoprotein 9
PVR poliovirus receptor
RAB3D RAB3D, member RAS oncogene family
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RASAL1 RAS protein activator like 1 (GAP1 like)
RPL7 ribosomal protein L7
RUNX1 runt-related transcription factor 1
SAP30 Sin3A-associated protein, 30kDa
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPON1 spondin 1, extracellular matrix protein
SRSF6 serine/arginine-rich splicing factor 6
SSTR4 somatostatin receptor 4
STAT5B signal transducer and activator of transcription 5B
TAOK2 TAO kinase 2
TEX14 testis expressed 14
TGFB2 transforming growth factor, beta 2
TLK1 tousled-like kinase 1
TRIM16 tripartite motif containing 16
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UHRF1BP1L UHRF1 binding protein 1-like
ZNF652 zinc finger protein 652
ZNF710 zinc finger protein 710

decreased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ABHD4 abhydrolase domain containing 4
ADCY6 adenylate cyclase 6
ALPK1 alpha-kinase 1
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ASAP1-IT1 ASAP1 intronic transcript 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
C16ORF59 chromosome 16 open reading frame 59
C3 complement component 3
CCNT1 cyclin T1
CDT1 chromatin licensing and DNA replication factor 1
CHD8 chromodomain helicase DNA binding protein 8
CLCN5 chloride channel, voltage-sensitive 5
CLEC16A C-type lectin domain family 16, member A
CNGA1 cyclic nucleotide gated channel alpha 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DEPTOR DEP domain containing MTOR-interacting protein
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTX2 deltex 2, E3 ubiquitin ligase
EFNA3 ephrin-A3
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM169A family with sequence similarity 169, member A
FBXO2 F-box protein 2
FKBP10 FK506 binding protein 10, 65 kDa
FLCN folliculin
GALT galactose-1-phosphate uridylyltransferase
GAS8 growth arrest-specific 8
GMEB1 glucocorticoid modulatory element binding protein 1
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HDAC11 histone deacetylase 11
HINFP histone H4 transcription factor
INF2 inverted formin, FH2 and WH2 domain containing
IQSEC2 IQ motif and Sec7 domain 2
KIAA0319L KIAA0319-like
KIAA0753 KIAA0753
KIAA0895 KIAA0895
KIAA1107 KIAA1107
KIFC1 kinesin family member C1
KLHL28 kelch-like family member 28
KLHL36 kelch-like family member 36
LIPG lipase, endothelial
LMNB1 lamin B1
LOC100286895 cell division cycle 27 homolog pseudogene
LYPD3 LY6/PLAUR domain containing 3
LZTR1 leucine-zipper-like transcription regulator 1
MCM3AP-AS1 MCM3AP antisense RNA 1
MFSD6 major facilitator superfamily domain containing 6
MGC12488
MIS18BP1 MIS18 binding protein 1
MNX1 motor neuron and pancreas homeobox 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MX1 MX dynamin-like GTPase 1
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCS1 neuronal calcium sensor 1
NPM3 nucleophosmin/nucleoplasmin 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
PARM1 prostate androgen-regulated mucin-like protein 1
PARP3 poly (ADP-ribose) polymerase family, member 3
PDE12 phosphodiesterase 12
PEX26 peroxisomal biogenesis factor 26
PLA1A phospholipase A1 member A
PLCD1 phospholipase C, delta 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
POLM polymerase (DNA directed), mu
POMT2 protein-O-mannosyltransferase 2
PRR7 proline rich 7 (synaptic)
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PTGFR prostaglandin F receptor (FP)
RALGDS ral guanine nucleotide dissociation stimulator
SKI SKI proto-oncogene
SLC39A7 solute carrier family 39 (zinc transporter), member 7
SLC44A1 solute carrier family 44 (choline transporter), member 1
SOX12 SRY (sex determining region Y)-box 12
SPIN1 spindlin 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK16 serine/threonine kinase 16
STON1 stonin 1
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAOK1 TAO kinase 1
TENM1 teneurin transmembrane protein 1
TINAGL1 tubulointerstitial nephritis antigen-like 1
TRIM25 tripartite motif containing 25
TUBA3C tubulin, alpha 3c
TUBG2 tubulin, gamma 2
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VASP vasodilator-stimulated phosphoprotein
XYLT2 xylosyltransferase II
YY2 YY2 transcription factor
ZBTB38 zinc finger and BTB domain containing 38
ZNF197 zinc finger protein 197
ZNF205 zinc finger protein 205
ZNF324 zinc finger protein 324