methazolamide-2733 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the methazolamide-2733 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM7 ADAM metallopeptidase domain 7
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ARHGAP28 Rho GTPase activating protein 28
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP8A bone morphogenetic protein 8a
C14ORF1 chromosome 14 open reading frame 1
C6ORF10 chromosome 6 open reading frame 10
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CALML3 calmodulin-like 3
CDHR2 cadherin-related family member 2
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPB centromere protein B, 80kDa
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CORO2B coronin, actin binding protein, 2B
CST1 cystatin SN
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
EBF2 early B-cell factor 2
EDDM3A epididymal protein 3A
EGFR epidermal growth factor receptor
EPHB2 EPH receptor B2
FAM106A family with sequence similarity 106, member A
FAM13C family with sequence similarity 13, member C
FGF6 fibroblast growth factor 6
FGFR2 fibroblast growth factor receptor 2
FLJ11292
FLJ21369 uncharacterized protein FLJ21369
FLT3LG fms-related tyrosine kinase 3 ligand
FLT4 fms-related tyrosine kinase 4
GRIA3 glutamate receptor, ionotropic, AMPA 3
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIST1H2AJ histone cluster 1, H2aj
HOXA6 homeobox A6
HOXB3 homeobox B3
HPR haptoglobin-related protein
HRK harakiri, BCL2 interacting protein
HSPB6 heat shock protein, alpha-crystallin-related, B6
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HTR7P1 5-hydroxytryptamine (serotonin) receptor 7 pseudogene 1
ICOS inducible T-cell co-stimulator
IL12B interleukin 12B
IL1RL1 interleukin 1 receptor-like 1
IL1RN interleukin 1 receptor antagonist
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1
KRT81 keratin 81, type II
KSR1 kinase suppressor of ras 1
LENEP lens epithelial protein
LMF1 lipase maturation factor 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MID1 midline 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NEK11 NIMA-related kinase 11
NLGN1 neuroligin 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NRG1 neuregulin 1
PADI4 peptidyl arginine deiminase, type IV
PAPOLB poly(A) polymerase beta (testis specific)
PAX8 paired box 8
PBOV1 prostate and breast cancer overexpressed 1
PDLIM5 PDZ and LIM domain 5
PICALM phosphatidylinositol binding clathrin assembly protein
PLCH1 phospholipase C, eta 1
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
POU1F1 POU class 1 homeobox 1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRDM12 PR domain containing 12
PRKCA protein kinase C, alpha
PRSS22 protease, serine, 22
PTGER3 prostaglandin E receptor 3 (subtype EP3)
RBM12B RNA binding motif protein 12B
RCE1 Ras converting CAAX endopeptidase 1
RPLP2 ribosomal protein, large, P2
SCN2B sodium channel, voltage gated, type II beta subunit
SEMG2 semenogelin II
SEZ6L seizure related 6 homolog (mouse)-like
SIGLEC5 sialic acid binding Ig-like lectin 5
SIGLEC8 sialic acid binding Ig-like lectin 8
SIX3 SIX homeobox 3
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SMR3B submaxillary gland androgen regulated protein 3B
SORBS2 sorbin and SH3 domain containing 2
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPRR2B small proline-rich protein 2B
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SYT1 synaptotagmin I
TJP3 tight junction protein 3
TLX2 T-cell leukemia homeobox 2
TMEM212 transmembrane protein 212
TRIO trio Rho guanine nucleotide exchange factor
XDH xanthine dehydrogenase
ZNF235 zinc finger protein 235
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMT aminomethyltransferase
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP5S1 adaptor-related protein complex 5, sigma 1 subunit
APOLD1 apolipoprotein L domain containing 1
C21ORF91 chromosome 21 open reading frame 91
C8ORF44 chromosome 8 open reading frame 44
C9ORF3 chromosome 9 open reading frame 3
CARF calcium responsive transcription factor
CCDC57 coiled-coil domain containing 57
CCDC71 coiled-coil domain containing 71
CEP295 centrosomal protein 295kDa
CHMP6 charged multivesicular body protein 6
CLCN5 chloride channel, voltage-sensitive 5
CLGN calmegin
CLIP2 CAP-GLY domain containing linker protein 2
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
CTC1 CTS telomere maintenance complex component 1
CTNNBL1 catenin, beta like 1
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DHRS11 dehydrogenase/reductase (SDR family) member 11
DUSP4 dual specificity phosphatase 4
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
EMILIN2 elastin microfibril interfacer 2
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ERCC2 excision repair cross-complementation group 2
F13A1 coagulation factor XIII, A1 polypeptide
FGL2 fibrinogen-like 2
FKBP9 FK506 binding protein 9, 63 kDa
FOXK2 forkhead box K2
FRS3 fibroblast growth factor receptor substrate 3
GBP2 guanylate binding protein 2, interferon-inducible
GID4 GID complex subunit 4
GK3P glycerol kinase 3 pseudogene
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GSTA4 glutathione S-transferase alpha 4
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HRAS Harvey rat sarcoma viral oncogene homolog
IKZF5 IKAROS family zinc finger 5 (Pegasus)
INCENP inner centromere protein antigens 135/155kDa
INF2 inverted formin, FH2 and WH2 domain containing
KCTD20 potassium channel tetramerization domain containing 20
KIAA0753 KIAA0753
KIAA1107 KIAA1107
KIF23 kinesin family member 23
KLF3 Kruppel-like factor 3 (basic)
KPNA4 karyopherin alpha 4 (importin alpha 3)
LIG4 ligase IV, DNA, ATP-dependent
LSP1 lymphocyte-specific protein 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBTPS2 membrane-bound transcription factor peptidase, site 2
MNS1 meiosis-specific nuclear structural 1
MYOZ3 myozenin 3
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NCALD neurocalcin delta
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NINJ2 ninjurin 2
NOL10 nucleolar protein 10
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PDZD7 PDZ domain containing 7
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIR pirin (iron-binding nuclear protein)
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
PLD3 phospholipase D family, member 3
PORCN porcupine homolog (Drosophila)
PRDM1 PR domain containing 1, with ZNF domain
PTH2R parathyroid hormone 2 receptor
R3HCC1L R3H domain and coiled-coil containing 1-like
SCD5 stearoyl-CoA desaturase 5
SCG5 secretogranin V
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2
SERINC5 serine incorporator 5
SGMS1 sphingomyelin synthase 1
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPAG1 sperm associated antigen 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX11 syntaxin 11
SYCP2 synaptonemal complex protein 2
TEC tec protein tyrosine kinase
THBS3 thrombospondin 3
TMEM180 transmembrane protein 180
TMEM242 transmembrane protein 242
TMEM53 transmembrane protein 53
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TWISTNB TWIST neighbor
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
USP6 ubiquitin specific peptidase 6
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WT1-AS WT1 antisense RNA
ZBTB25 zinc finger and BTB domain containing 25
ZFP30 ZFP30 zinc finger protein
ZNF219 zinc finger protein 219
ZNF225 zinc finger protein 225
ZNHIT2 zinc finger, HIT-type containing 2